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| | cds2 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (444 aa) |
| | pip4k2aa | Similar to type II phosphatidylinositolphosphate kinase-alpha. (404 aa) |
| | E7F3N0_DANRE | Si:ch211-160o17.2. (379 aa) |
| | mtmr8 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (By similarity). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (632 aa) |
| | mtmr2 | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). (620 aa) |
| | pip5k1bb | Phosphatidylinositol-4-phosphate 5-kinase, type I, beta b. (527 aa) |
| | itpk1a | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. May also act as an isomerase that interconverts the inositol tetrakisphos [...] (396 aa) |
| | calm2a | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa) |
| | ip6k2a | Kinase; Belongs to the inositol phosphokinase (IPK) family. (463 aa) |
| | pip5k1ab | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b. (584 aa) |
| | dgkh | Diacylglycerol kinase. (1223 aa) |
| | pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | impa1 | Inositol-1-monophosphatase. (282 aa) |
| | ip6k2b | Kinase; Belongs to the inositol phosphokinase (IPK) family. (430 aa) |
| | prkcba | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa) |
| | mtmr6 | Myotubularin-related protein 6. (643 aa) |
| | pip4p1b | Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. (262 aa) |
| | itpr1b | Inositol 1,4,5-trisphosphate receptor, type 1b. (2782 aa) |
| | mtmr1b | Myotubularin-related protein 1b. (649 aa) |
| | pi4k2b | Phosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). (501 aa) |
| | prkcbb | Protein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa) |
| | pik3r3b | Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (464 aa) |
| | pip4k2ca | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2). (417 aa) |
| | plcd1b | Phosphoinositide phospholipase C. (749 aa) |
| | ipmkb | Kinase; Belongs to the inositol phosphokinase (IPK) family. (372 aa) |
| | F1R561_DANRE | Diacylglycerol kinase. (1074 aa) |
| | mtmr7a | Myotubularin-related protein 7a. (655 aa) |
| | pik3r1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa) |
| | pi4kb | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). (835 aa) |
| | pip5k1ca | Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (682 aa) |
| | itpka | Kinase; Belongs to the inositol phosphokinase (IPK) family. (448 aa) |
| | pip5k1ba | Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a. (521 aa) |
| | pip4p2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) |
| | plcd3b | Phosphoinositide phospholipase C. (769 aa) |
| | plcg2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1240 aa) |
| | impad1 | Inositol monophosphatase 3; Belongs to the inositol monophosphatase superfamily. (341 aa) |
| | impa2 | Inositol-1-monophosphatase. (275 aa) |
| | mtmr14 | Myotubularin-related protein 14. (630 aa) |
| | sacm1lb | Phosphatidylinositide phosphatase SAC1-B; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity). (586 aa) |
| | dgkaa | Diacylglycerol kinase. (727 aa) |
| | sacm1la | Phosphatidylinositide phosphatase SAC1-A; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity). (586 aa) |
| | DGKI | Diacylglycerol kinase. (732 aa) |
| | plcb3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa) |
| | pik3c3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa) |
| | plcd3a | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity). (784 aa) |
| | cdipt | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa) |
| | ppip5k1a | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1345 aa) |
| | ocrl | OCRL inositol polyphosphate-5-phosphatase. (953 aa) |
| | calml4a | Calmodulin-like 4a. (153 aa) |
| | pi4kaa | Phosphatidylinositol 4-kinase, catalytic, alpha a; Belongs to the PI3/PI4-kinase family. (2059 aa) |
| | ppip5k1b | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1178 aa) |
| | inpp4b | Inositol polyphosphate-4-phosphatase type II B. (836 aa) |
| | Plcb2 | Phosphoinositide phospholipase C. (694 aa) |
| | ptena | Phosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (467 aa) |
| | pip4k2cb | Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b. (416 aa) |
| | pik3c2b | Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1587 aa) |
| | plce1 | Phospholipase C, epsilon 1. (2248 aa) |
| | pi4k2a | Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). (447 aa) |
| | ipmka | Kinase; Belongs to the inositol phosphokinase (IPK) family. (318 aa) |
| | ippk | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left- right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification. (483 aa) |
| | pip4p1a | Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. (270 aa) |
| | ppip5k2 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1224 aa) |
| | itpkcb | Kinase; Belongs to the inositol phosphokinase (IPK) family. (474 aa) |
| | itpkca | Kinase; Belongs to the inositol phosphokinase (IPK) family. (417 aa) |
| | plcg1 | Phosphoinositide phospholipase C. (1020 aa) |
| | pik3c2a | Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1725 aa) |
| | inpp5f | Phosphatidylinositide phosphatase SAC2; Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. (1120 aa) |
| | synj1 | Synaptojanin 1. (1308 aa) |
| | itpkb | Kinase; Belongs to the inositol phosphokinase (IPK) family. (657 aa) |
| | prkcg | Protein kinase C, gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (654 aa) |
| | mtmr1a | Myotubularin-related protein 1a. (683 aa) |
| | pikfyve | Phosphatidylinositol phosphate 5-kinase type III isoform d. (2075 aa) |
| | mtm1 | Myotubularin 1. (639 aa) |
| | calml4b | Calmodulin-like 4b. (169 aa) |
| | pik3cb | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa) |
| | itpk1b | Inositol-tetrakisphosphate 1-kinase b. (401 aa) |
| | itpr2 | Inositol 1,4,5-trisphosphate receptor, type 2. (2008 aa) |
| | dgkzb | Diacylglycerol kinase. (1057 aa) |
| | inppl1a | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of [...] (1003 aa) |
| | pik3r2 | Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa) |
| | pip5k1aa | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a. (559 aa) |
| | dgke | Diacylglycerol kinase. (566 aa) |
| | mtmr7b | Myotubularin-related protein 7b. (567 aa) |
| | itpr3 | Inositol 1,4,5-trisphosphate receptor, type 3. (2634 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1143 aa) |
| | cds1 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (452 aa) |
| | inpp5e | Inositol polyphosphate-5-phosphatase E. (584 aa) |
| | pip5k1cb | Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b. (697 aa) |
| | prkcab | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (635 aa) |
| | pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | mtmr3 | Myotubularin-related protein 3. (373 aa) |
| | pik3c2g | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1013 aa) |
| | inpp5b | Inositol polyphosphate-5-phosphatase B. (907 aa) |
| | dgkab | Diacylglycerol kinase. (727 aa) |
| | inppl1b | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of [...] (1226 aa) |
| | dgkza | Diacylglycerol kinase. (1222 aa) |
| | plcd4a | Phosphoinositide phospholipase C. (761 aa) |
| | inpp4ab | Inositol polyphosphate-4-phosphatase type I Ab. (917 aa) |
| | ip6k1 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (430 aa) |
| | ENSDARP00000148213 | PH_14 domain-containing protein. (208 aa) |
| | LOC567728 | Diacylglycerol kinase. (886 aa) |
| | dgkb | Diacylglycerol kinase. (771 aa) |
| | itpr1a | Inositol 1,4,5-trisphosphate receptor, type 1a. (2745 aa) |
| | plcd1a | Phosphoinositide phospholipase C. (781 aa) |
| | prkcaa | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
