STRINGSTRING
mcm6l mcm6l fzr1a fzr1a cdc25b cdc25b mad2l1 mad2l1 mcm3 mcm3 ccnh ccnh gadd45bb gadd45bb ywhah ywhah cdc6 cdc6 gadd45gb.1 gadd45gb.1 rad21a rad21a cdkn1ca cdkn1ca cdc14aa cdc14aa mycb mycb atm atm skp1 skp1 mcm5 mcm5 ywhae2 ywhae2 ccna1 ccna1 rb1 rb1 mcm6 mcm6 ywhaqb ywhaqb gadd45ga gadd45ga smc3 smc3 tgfb3 tgfb3 ywhaba ywhaba gsk3ba gsk3ba gadd45ba gadd45ba cdk2 cdk2 ywhae1 ywhae1 orc5 orc5 chek2 chek2 ccnd3 ccnd3 ywhaz ywhaz smad3b smad3b smad3a smad3a orc3 orc3 cdkn1ba cdkn1ba cdk21 cdk21 cdk7 cdk7 prkdc prkdc hdac1 hdac1 ccnb2 ccnb2 mcm3l mcm3l rbx1 rbx1 e2f5 e2f5 anapc4 anapc4 mcm4 mcm4 ywhabl ywhabl tgfb1a tgfb1a mad2l2 mad2l2 ywhaqa ywhaqa ccnb1 ccnb1 gadd45aa gadd45aa cdc45 cdc45 cdc23 cdc23 dbf4 dbf4 ccnd2a ccnd2a rbl2 rbl2 rbl1 rbl1 gsk3bb gsk3bb pttg1 pttg1 pcna pcna cdkn1bb cdkn1bb tfdp1a tfdp1a cdc16 cdc16 mdm2 mdm2 smc1a smc1a rad21l1 rad21l1 ywhag1 ywhag1 smc1al smc1al plk1 plk1 anapc7 anapc7 cdk4 cdk4 cdc7 cdc7 skp2 skp2 ccnd2b ccnd2b cdc14ab cdc14ab ywhag2 ywhag2 tgfb5 tgfb5 smad4a smad4a gb:cr929477 gb:cr929477 E7FFJ8_DANRE E7FFJ8_DANRE myca myca cdc26 cdc26 pkmyt1 pkmyt1 ywhabb ywhabb orc6 orc6 ccnb3 ccnb3 wee1 wee1 smad2 smad2 cdk1 cdk1 cul1a cul1a e2f3 e2f3 wee2 wee2 orc1 orc1 stag2a stag2a stag1a stag1a cdkn1a cdkn1a tp53 tp53 B0S5T4_DANRE B0S5T4_DANRE bub1 bub1 cdkn2c cdkn2c atr atr cul1b cul1b Q1L8R8_DANRE Q1L8R8_DANRE stag1b stag1b ttk ttk tgfb1b tgfb1b rad21b rad21b mad1l1 mad1l1 anapc13 anapc13 tgfb2 tgfb2 E7FFZ5_DANRE E7FFZ5_DANRE abl1 abl1 cdc14b cdc14b anapc10 anapc10 bub3 bub3 fzr1b fzr1b smc1b smc1b espl1 espl1 ep300b ep300b tfdp2 tfdp2 anapc11 anapc11 orc4 orc4 anapc5 anapc5 e2f4 e2f4 mcm2 mcm2 chek1 chek1 crebbpa crebbpa gadd45ab gadd45ab e2f1 e2f1 anapc2 anapc2 ep300a ep300a crebbpb crebbpb cdkn1cb cdkn1cb ccnd1 ccnd1 cdc20 cdc20 ccne2 ccne2 ccne1 ccne1 stag2b stag2b anapc1 anapc1 cdkn2d cdkn2d
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm6lDNA helicase; Belongs to the MCM family. (824 aa)
fzr1aFizzy/cell division cycle 20 related 1 (Drosophila). (495 aa)
cdc25bCell division cycle 25B. (563 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
mcm3DNA helicase; Belongs to the MCM family. (807 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
gadd45bbGrowth arrest and DNA-damage-inducible, beta like. (158 aa)
ywhahTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
gadd45gb.1Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (155 aa)
rad21aDouble-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa)
cdkn1caCyclin-dependent kinase inhibitor 1C (P57, Kip2). (212 aa)
cdc14aaCell division cycle 14Aa. (592 aa)
mycbTranscriptional regulator Myc-B; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (396 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
skp1S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa)
mcm5DNA helicase; Belongs to the MCM family. (736 aa)
ywhae2Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (255 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (391 aa)
rb1Retinoblastoma 1. (903 aa)
mcm6DNA helicase; Belongs to the MCM family. (830 aa)
ywhaqbTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (245 aa)
gadd45gaGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
smc3Structural maintenance of chromosomes protein. (1216 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
ywhaba14-3-3 protein beta/alpha-A; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (244 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
gadd45baGrowth arrest and DNA-damage-inducible, beta a. (159 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ywhae1Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa)
orc5Origin recognition complex, subunit 5-like (Yeast). (444 aa)
chek2Checkpoint kinase 2. (503 aa)
ccnd3Cyclin D3; Belongs to the cyclin family. (277 aa)
ywhazTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (244 aa)
smad3bMothers against decapentaplegic homolog. (423 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
orc3Origin recognition complex, subunit 3. (706 aa)
cdkn1baCyclin-dependent kinase inhibitor 1Ba. (187 aa)
cdk21Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (305 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (345 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4119 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
ccnb2Cyclin B2; Belongs to the cyclin family. (386 aa)
mcm3lDNA helicase; Belongs to the MCM family. (807 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
e2f5E2F transcription factor 5. (363 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (797 aa)
mcm4DNA helicase; Belongs to the MCM family. (845 aa)
ywhablTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-like; Belongs to the 14-3-3 family. (245 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
mad2l2Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa)
ywhaqaTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (245 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (397 aa)
gadd45aaGrowth arrest and DNA-damage-inducible, alpha, a. (157 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (572 aa)
cdc23CDC23 (Cell division cycle 23, yeast, homolog). (579 aa)
dbf4DBF4 zinc finger. (612 aa)
ccnd2aCyclin D2, a; Belongs to the cyclin family. (298 aa)
rbl2Retinoblastoma-like 2 (p130). (1079 aa)
rbl1Retinoblastoma-like 1 (p107). (1058 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
pttg1PTTG1 regulator of sister chromatid separation, securin. (182 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
tfdp1aTranscription factor. (409 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (616 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. (475 aa)
smc1aStructural maintenance of chromosomes protein. (1232 aa)
rad21l1RAD21 cohesin complex component-like 1. (546 aa)
ywhag114-3-3 protein gamma-1; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (247 aa)
smc1alStructural maintenance of chromosomes protein. (1233 aa)
plk1Serine/threonine-protein kinase PLK. (595 aa)
anapc7Anaphase-promoting complex subunit 7. (566 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (297 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (459 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)
ccnd2bCyclin D2, b; Belongs to the cyclin family. (295 aa)
cdc14abDual specificity protein phosphatase CDC14AB; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. (510 aa)
ywhag23-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
gb:cr929477SMAD family member 4. (332 aa)
E7FFJ8_DANRESi:ch211-160f23.5. (438 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
cdc26Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex; Belongs to the CDC26 [...] (88 aa)
pkmyt1Protein kinase, membrane-associated tyrosine/threonine 1. (554 aa)
ywhabb14-3-3 protein beta/alpha-B; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (242 aa)
orc6Origin recognition complex, subunit 6 homolog-like (Yeast). (256 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (398 aa)
wee1Wee1-like protein kinase. (612 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
cdk1Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa)
cul1aCullin 1a; Belongs to the cullin family. (777 aa)
e2f3E2F transcription factor 3. (429 aa)
wee2Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (532 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (912 aa)
stag2aStromal antigen 2a. (1246 aa)
stag1aStromal antigen 1a. (1263 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (154 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
B0S5T4_DANRESi:ch211-269e2.1. (1174 aa)
bub1BUB1 mitotic checkpoint serine/threonine kinase. (1202 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (170 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
cul1bCullin 1b; Belongs to the cullin family. (775 aa)
Q1L8R8_DANREMothers against decapentaplegic homolog. (571 aa)
stag1bStromal antigen 1b. (1256 aa)
ttkDual specificity protein kinase Ttk; Phosphorylates proteins on serine, threonine, and tyrosine (By similarity). Involved in mitotic cell cycle checkpoint control. Required for fin and heart regeneration. Required to prevent chromosome segregation errors during meiosis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (983 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
rad21bRAD21 cohesin complex component b. (637 aa)
mad1l1Mitotic arrest deficient-like protein 1. (717 aa)
anapc13Anaphase-promoting complex subunit 13. (74 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
E7FFZ5_DANREMothers against decapentaplegic homolog. (568 aa)
abl1Tyrosine-protein kinase. (1081 aa)
cdc14bCell division cycle 14B. (476 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
bub3BUB3 mitotic checkpoint protein. (338 aa)
fzr1bFizzy/cell division cycle 20-related 1b. (485 aa)
smc1bStructural maintenance of chromosomes protein. (1234 aa)
espl1Extra spindle pole bodies-like 1, separase. (2182 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
tfdp2Transcription factor. (409 aa)
anapc11APC11 anaphase-promoting complex subunit 11 homolog (yeast). (88 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (432 aa)
anapc5Anaphase-promoting complex subunit 5. (718 aa)
e2f4E2F transcription factor 4. (404 aa)
mcm2DNA helicase; Belongs to the MCM family. (889 aa)
chek1CHK1 checkpoint homolog (S. pombe); Belongs to the protein kinase superfamily. (410 aa)
crebbpaCREB-binding protein a. (2349 aa)
gadd45abGrowth arrest and DNA-damage-inducible, alpha, b. (156 aa)
e2f1E2F transcription factor 1. (429 aa)
anapc2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (802 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
crebbpbCREB-binding protein b. (2431 aa)
cdkn1cbCyclin-dependent kinase inhibitor 1Cb. (172 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
cdc20Cell division cycle 20 homolog. (496 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (392 aa)
ccne1G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (410 aa)
stag2bStromal antigen 2b. (1276 aa)
anapc1Anaphase-promoting complex subunit 1. (1932 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (168 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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