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| | prkacab | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa) |
| | vmp1 | Vacuole membrane protein 1; Belongs to the VMP1 family. (406 aa) |
| | hif1ab | Hypoxia-inducible factor 1 subunit alpha b. (777 aa) |
| | uvrag | UV radiation resistance-associated gene. (664 aa) |
| | smcr8b | Guanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa) |
| | zgc:171927 | Zgc:171927. (210 aa) |
| | zgc:101559 | Zgc:101559. (233 aa) |
| | C13H9orf72 | Zgc:100846. (462 aa) |
| | map3k7 | Mitogen-activated protein kinase kinase kinase 7. (551 aa) |
| | map2k1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa) |
| | napsa | Napsin A aspartic peptidase; Belongs to the peptidase A1 family. (412 aa) |
| | mapk8b | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa) |
| | rps6kb1a | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (506 aa) |
| | ATG14 | Zgc:113944. (517 aa) |
| | rras | Related RAS viral (R-ras) oncogene homolog. (196 aa) |
| | map2k2a | Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa) |
| | igbp1 | Immunoglobulin (CD79A)-binding protein 1. (355 aa) |
| | rragd | Ras-related GTP-binding D. (394 aa) |
| | hrasb | -Ha-ras Harvey rat sarcoma viral oncogene homolog, like. (189 aa) |
| | igf1ra | Tyrosine-protein kinase receptor. (1405 aa) |
| | pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | sh3glb1a | SH3-domain GRB2-like endophilin B1a. (360 aa) |
| | pdpk1b | 3-phosphoinositide-dependent protein kinase 1b. (537 aa) |
| | atg4a | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (375 aa) |
| | rab39ba | RAB39B, member RAS oncogene family a. (213 aa) |
| | ctsl.1 | Cathepsin L.1; Belongs to the peptidase C1 family. (334 aa) |
| | rab7a | RAB7a, member RAS oncogene family. (207 aa) |
| | zgc:55558 | Zgc:55558 protein. (187 aa) |
| | akt2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | prkacba | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa) |
| | rab7b | RAB7b, member RAS oncogene family. (204 aa) |
| | eif2s1a | Eukaryotic translation initiation factor 2, subunit 1 alpha, like. (315 aa) |
| | bcl2l1 | Bcl-XL-like protein 1. (238 aa) |
| | nrbf2b | Nuclear receptor-binding factor 2b. (247 aa) |
| | bnip4 | BCL2-interacting protein 4. (177 aa) |
| | vamp8 | Vesicle-associated membrane protein 8 (Endobrevin). (124 aa) |
| | itpr1b | Inositol 1,4,5-trisphosphate receptor, type 1b. (2782 aa) |
| | prkcda | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa) |
| | tsc1a | TSC complex subunit 1a. (1128 aa) |
| | traf6 | TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa) |
| | zgc:73226 | Zgc:73226. (187 aa) |
| | mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa) |
| | gabarapl2 | GABA(A) receptor-associated protein-like 2. (117 aa) |
| | pik3r3b | Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (464 aa) |
| | atg3 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] (317 aa) |
| | ppp2ca | Serine/threonine-protein phosphatase. (309 aa) |
| | rab1ab | RAB1A, member RAS oncogene family b. (201 aa) |
| | hif1aa | Hypoxia-inducible factor 1 subunit alpha a. (717 aa) |
| | F1QN42_DANRE | Si:dkey-240h12.4; Belongs to the protein kinase superfamily. (361 aa) |
| | sh3glb1b | SH3-domain GRB2-like endophilin B1b. (360 aa) |
| | prkcq | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (713 aa) |
| | igf1rb | Tyrosine-protein kinase receptor. (1380 aa) |
| | ins | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | gabarapa | GABA(A) receptor-associated protein a. (122 aa) |
| | atg4c | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (463 aa) |
| | atg13 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. (503 aa) |
| | rras2 | Related RAS viral (R-ras) oncogene homolog 2. (202 aa) |
| | irs2a | Insulin receptor substrate 2a. (1032 aa) |
| | nras | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa) |
| | pik3r1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa) |
| | rhebl1 | Ras homolog, mTORC1-binding-like 1. (184 aa) |
| | wipi1 | WD repeat domain, phosphoinositide-interacting 1. (453 aa) |
| | zgc:92606 | Zgc:92606. (117 aa) |
| | cts12 | Cathepsin 12; Belongs to the peptidase C1 family. (349 aa) |
| | atg101 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family. (218 aa) |
| | atg9a | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa) |
| | stk11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | gabarapb | GABA(A) receptor-associated protein b. (152 aa) |
| | eif2s1b | Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa) |
| | rab1aa | RAB1A, member RAS oncogene family a. (201 aa) |
| | rab33ba | RAB33B, member RAS oncogene family a. (239 aa) |
| | smcr8a | Guanine nucleotide exchange protein smcr8a; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (853 aa) |
| | irs1 | Insulin receptor substrate 1. (1099 aa) |
| | badb | BCL2-associated agonist of cell death b. (147 aa) |
| | ctsba | Cathepsin B, a; Belongs to the peptidase C1 family. (330 aa) |
| | cflara | CASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa) |
| | ctsd | Ctsd protein; Belongs to the peptidase A1 family. (398 aa) |
| | rps6kb1b | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa) |
| | prkacbb | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa) |
| | raf1b | Raf-1 proto-oncogene, serine/threonine kinase b. (629 aa) |
| | mtmr14 | Myotubularin-related protein 14. (630 aa) |
| | pik3r4 | Phosphoinositide-3-kinase, regulatory subunit 4. (1347 aa) |
| | prkaa1 | Non-specific serine/threonine protein kinase. (573 aa) |
| | prkaa2 | Non-specific serine/threonine protein kinase. (553 aa) |
| | dapk2a | Death-associated protein kinase 2a; Belongs to the protein kinase superfamily. (484 aa) |
| | ulk1a | Unc-51-like autophagy-activating kinase 1a. (927 aa) |
| | ambra1a | Activating molecule in beclin-1-regulated autophagy. (1315 aa) |
| | atg16l2 | ATG16 autophagy-related 16-like 2 (S. cerevisiae). (302 aa) |
| | pik3c3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa) |
| | atg12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (120 aa) |
| | rab39bb | RAB39B, member RAS oncogene family b. (213 aa) |
| | rragca | Ras-related GTP-binding Ca. (380 aa) |
| | pdpk1a | 3-phosphoinositide-dependent protein kinase 1a. (536 aa) |
| | F1QYY8_DANRE | Si:dkeyp-97e7.9. (393 aa) |
| | mapk3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa) |
| | si:dkey-26g8.5 | MGC174857 protein; Belongs to the peptidase C1 family. (335 aa) |
| | rb1cc1 | RB1-inducible coiled-coil 1. (1622 aa) |
| | zgc:174855 | Im:6910535 protein; Belongs to the peptidase C1 family. (335 aa) |
| | mapk9 | Mitogen-activated protein kinase. (421 aa) |
| | becn1 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa) |
| | zgc:174154 | Im:6910535; Belongs to the peptidase C1 family. (335 aa) |
| | zfyve1 | Zinc finger, FYVE domain-containing 1. (779 aa) |
| | zgc:100918 | Zgc:100918. (208 aa) |
| | mtor | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | F1QYV4_DANRE | Si:dkey-13a21.4. (205 aa) |
| | ptena | Phosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (467 aa) |
| | atg4b | Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity); Belongs to the peptidase C54 family. (394 aa) |
| | ctsla | Cathepsin La; Belongs to the peptidase C1 family. (337 aa) |
| | wdr41 | WD repeat domain 41. (449 aa) |
| | rheb | Ras homolog, mTORC1-binding. (93 aa) |
| | irs4a | Insulin receptor substrate 4a. (1051 aa) |
| | bada | BCL2-associated agonist of cell death a. (145 aa) |
| | E7F8Y7_DANRE | Si:dkey-239j18.3; Belongs to the peptidase C1 family. (336 aa) |
| | akt3b | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ulk1b | Unc-51-like autophagy-activating kinase 1. (1011 aa) |
| | stx17 | Syntaxin 17. (292 aa) |
| | insb | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa) |
| | ern2 | Endoplasmic reticulum to nucleus-signaling 2. (927 aa) |
| | snap29 | Synaptosome-associated protein 29. (232 aa) |
| | sqstm1 | Sequestosome 1. (452 aa) |
| | mlst8 | Target of rapamycin complex subunit lst8. (326 aa) |
| | wipi2 | WD repeat domain, phosphoinositide-interacting 2. (425 aa) |
| | tsc1b | TSC complex subunit 1b. (1228 aa) |
| | ctslb | Cathepsin Lb; Belongs to the peptidase C1 family. (352 aa) |
| | dapk3 | Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (453 aa) |
| | atg9b | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (806 aa) |
| | bcl2a | B-cell leukemia/lymphoma 2. (228 aa) |
| | eif2ak3 | Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa) |
| | supt20 | SPT20 homolog, SAGA complex component. (829 aa) |
| | lamp1b | Lysosomal-associated membrane protein 1b. (253 aa) |
| | deptor | DEP domain-containing MTOR-interacting protein. (407 aa) |
| | E9QBE2_DANRE | Si:dkey-239j18.2; Belongs to the peptidase C1 family. (335 aa) |
| | atg5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | MRAS | Si:ch73-116o1.2. (208 aa) |
| | map2k2b | Mitogen-activated protein kinase kinase 2b; Belongs to the protein kinase superfamily. (395 aa) |
| | bcl2b | BCL2 apoptosis regulator b. (209 aa) |
| | rab8a | RAB8A, member RAS oncogene family. (207 aa) |
| | zgc:56064 | Serine/threonine-protein phosphatase. (309 aa) |
| | zgc:174153 | Zgc:174153; Belongs to the peptidase C1 family. (336 aa) |
| | atg4da | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (485 aa) |
| | ddit4 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (220 aa) |
| | akt1s1 | AKT1 substrate 1 (proline-rich). (354 aa) |
| | pik3cb | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa) |
| | ulk2 | Unc-51-like autophagy-activating kinase 2. (1034 aa) |
| | prkcdb | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa) |
| | hmgb1b | High mobility group box 1b. (197 aa) |
| | ambra1b | Autophagy/beclin-1 regulator 1b. (1360 aa) |
| | pik3r2 | Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa) |
| | atg16l1 | ATG16 autophagy-related 16-like 1 (S. cerevisiae). (621 aa) |
| | raf1a | Raf-1 proto-oncogene, serine/threonine kinase a. (654 aa) |
| | akt1 | Non-specific serine/threonine protein kinase. (247 aa) |
| | tsc2 | TSC complex subunit 2. (1674 aa) |
| | rptor | Regulatory-associated protein of MTOR, complex 1. (1363 aa) |
| | hif1al | Hypoxia-inducible factor 1 subunit alpha,-like. (626 aa) |
| | tbk1 | TANK-binding kinase 1. (727 aa) |
| | hmgb1a | High mobility group box 1a. (205 aa) |
| | mapk10 | Mitogen-activated protein kinase. (472 aa) |
| | ATG2A | Si:ch73-45o6.2. (2022 aa) |
| | tank | TRAF family member-associated NFKB activator. (348 aa) |
| | prkacaa | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa) |
| | dapk2b | Death-associated protein kinase 2b; Belongs to the protein kinase superfamily. (368 aa) |
| | irs2b | Insulin receptor substrate 2b. (1062 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1355 aa) |
| | pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | akt3a | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | mtmr3 | Myotubularin-related protein 3. (373 aa) |
| | bnip3 | BCL2-interacting protein 3. (183 aa) |
| | ppp2cb | Serine/threonine-protein phosphatase. (309 aa) |
| | atg10 | ATG10 autophagy-related 10 homolog (S. cerevisiae). (224 aa) |
| | akt2l | V-akt murine thymoma viral oncogene homolog 2,-like. (478 aa) |
| | ctsbb | Cathepsin Bb; Belongs to the peptidase C1 family. (327 aa) |
| | rragcb | Ras-related GTP-binding Cb. (392 aa) |
| | hrasa | HRas proto-oncogene, GTPase a. (189 aa) |
| | ENSDARP00000142540 | Si:ch73-234b20.5. (101 aa) |
| | mras | Muscle RAS oncogene homolog. (209 aa) |
| | mapk8a | Mitogen-activated protein kinase. (427 aa) |
| | rubcn | Rubicon autophagy regulator. (956 aa) |
| | itpr1a | Inositol 1,4,5-trisphosphate receptor, type 1a. (2745 aa) |
| | dapk1 | Death-associated protein kinase 1. (1477 aa) |
