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| | rhocb | Rho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | prkacab | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa) |
| | wnt10a | Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development. Regulates the expression of genes involved in tooth development. Belongs to the Wnt family. (442 aa) |
| | csnk2a1 | Casein kinase 2, alpha 1 polypeptide; Belongs to the protein kinase superfamily. (395 aa) |
| | map3k7 | Mitogen-activated protein kinase kinase kinase 7. (551 aa) |
| | fzd9b | Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | tcf7l2 | Transcription factor 7-like 2 (T-cell specific, HMG-box). (477 aa) |
| | mycb | Transcriptional regulator Myc-B; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (396 aa) |
| | chd8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity. Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive [...] (2555 aa) |
| | wnt7ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | fosl1a | FOS-like 1, AP-1 transcription factor subunit a. (346 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | ruvbl1 | RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family. (456 aa) |
| | prickle2a | Prickle homolog 2a. (869 aa) |
| | mapk8b | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa) |
| | skp1 | S-phase kinase-associated protein 1A; Belongs to the SKP1 family. (163 aa) |
| | dkk1a | Dickkopf WNT-signaling pathway inhibitor 1a. (256 aa) |
| | fbxw11b | F-box and WD repeat domain-containing 11b. (531 aa) |
| | rhoab | Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | nkd2a | Protein naked cuticle homolog 2-like; Cell autonomous antagonist of both the canonical and non- canonical Wnt signaling pathways; Belongs to the NKD family. (409 aa) |
| | wif1 | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. (378 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | daam1a | Dishevelled-associated activator of morphogenesis 1a. (1084 aa) |
| | prkacba | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa) |
| | ppp3ca | Serine/threonine-protein phosphatase. (521 aa) |
| | zgc:86598 | Zgc:86598; Belongs to the protein kinase superfamily. (393 aa) |
| | prkcba | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa) |
| | daam1b | Dishevelled-associated activator of morphogenesis 1b. (1079 aa) |
| | csnk2a2a | Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (348 aa) |
| | gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) |
| | vangl1 | Vang-like protein. (527 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | ppp3cb | Serine/threonine-protein phosphatase. (511 aa) |
| | fzd5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa) |
| | ccnd3 | Cyclin D3; Belongs to the cyclin family. (277 aa) |
| | fzd7b | Frizzled class receptor 7b; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa) |
| | prkcbb | Protein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa) |
| | camk2a | Calcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa) |
| | rhoaa | Rho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | smad3b | Mothers against decapentaplegic homolog. (423 aa) |
| | siah1 | E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family. (286 aa) |
| | smad3a | Mothers against decapentaplegic homolog. (425 aa) |
| | csnk2a2b | Casein kinase 2, alpha prime polypeptide b; Belongs to the protein kinase superfamily. (350 aa) |
| | tle3a | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa) |
| | porcn | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (442 aa) |
| | wnt2bb | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | notum1a | Palmitoleoyl-protein carboxylesterase notum1a; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway. Acts by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity); Belongs to the pectinacetylesterase family. Notum subfamily. (500 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | sfrp1a | Secreted frizzled-related protein 1a. (296 aa) |
| | nfatc1 | Nuclear factor of-activated T cells 1. (867 aa) |
| | dand5 | DAN domain family, member 5. (243 aa) |
| | wnt9b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | rbx1 | Ring-box 1, E3 ubiquitin protein ligase. (108 aa) |
| | wnt6a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | fzd8b | Frizzled class receptor 8b; Belongs to the G-protein coupled receptor Fz/Smo family. (576 aa) |
| | ctnnbip1 | Catenin, beta-interacting protein 1. (81 aa) |
| | sfrp5 | Secreted frizzled-related protein 5. (310 aa) |
| | rspo3 | R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and prunin [...] (317 aa) |
| | gbp | Glycogen synthase kinase-binding protein. (149 aa) |
| | prickle1a | Prickle homolog 1a. (793 aa) |
| | wnt10b | Protein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer. (427 aa) |
| | wnt2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). (350 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | wnt7aa | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | csnk1e | Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (417 aa) |
| | dkk1b | Dickkopf WNT-signaling pathway inhibitor 1b. (241 aa) |
| | fzd8a | Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | nfatc3a | Nuclear factor of-activated T cells 3a. (1074 aa) |
| | ccnd2a | Cyclin D2, a; Belongs to the cyclin family. (298 aa) |
| | porcnl | Porcupine O-acyltransferase-like; Belongs to the membrane-bound acyltransferase family. (449 aa) |
| | gsk3bb | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa) |
| | ccn4a | Cellular communication network factor 4a. (360 aa) |
| | fzd2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa) |
| | bambia | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (258 aa) |
| | wnt1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa) |
| | ryk | Receptor-like tyrosine kinase. (604 aa) |
| | ppp3ccb | Serine/threonine-protein phosphatase. (506 aa) |
| | sfrp1b | Secreted frizzled-related protein 1b. (300 aa) |
| | ctnnb2 | Catenin, beta 2. (778 aa) |
| | LOC568110 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | prkacbb | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa) |
| | tbl1x | Transducin beta-like 1 X-linked. (510 aa) |
| | sost | Sclerostin. (210 aa) |
| | ctnnd2b | Catenin (cadherin-associated protein), delta 2b. (1210 aa) |
| | fzd3a | Transmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (685 aa) |
| | apc2 | APC regulator of WNT-signaling pathway 2. (2105 aa) |
| | dvl3a | Dishevelled segment polarity protein 3a. (676 aa) |
| | wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | fzd10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) |
| | plcb3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa) |
| | cacybp | Calcyclin-binding protein. (227 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | serpinf1 | Zgc:92072; Belongs to the serpin family. (406 aa) |
| | ppp3r1b | Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (170 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (294 aa) |
| | ccnd2b | Cyclin D2, b; Belongs to the cyclin family. (295 aa) |
| | wnt2ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa) |
| | dvl1b | Dishevelled segment polarity protein 1b. (716 aa) |
| | wnt4 | Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa) |
| | camk2g1 | Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1. (560 aa) |
| | rac1a | Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa) |
| | smad4a | Mothers against decapentaplegic homolog. (547 aa) |
| | LOC571865 | Nuclear factor of-activated T cells 2b. (792 aa) |
| | csnk2b | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (215 aa) |
| | dkk2 | Dickkopf WNT-signaling pathway inhibitor 2. (243 aa) |
| | mapk9 | Mitogen-activated protein kinase. (421 aa) |
| | ccn4b | Cellular communication network factor 4b. (356 aa) |
| | gb:cr929477 | SMAD family member 4. (332 aa) |
| | wnt4b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | myca | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa) |
| | nlk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (475 aa) |
| | rspo2 | R-spondin 2_variant1. (248 aa) |
| | ror2 | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (939 aa) |
| | senp2 | SUMO-specific peptidase 2. (598 aa) |
| | nfatc4 | Nuclear factor of-activated T cells 4. (865 aa) |
| | wnt6b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | Plcb2 | Phosphoinositide phospholipase C. (694 aa) |
| | tbl1xr1a | Tbl1x receptor 1a. (416 aa) |
| | rac1b | Ras-related C3 botulinum toxin substrate 1-like protein. (192 aa) |
| | fzd7a | Frizzled class receptor 7a; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa) |
| | rac2 | Rac family small GTPase 2. (219 aa) |
| | nlk2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (533 aa) |
| | ctbp1 | C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (449 aa) |
| | fzd3b | Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (667 aa) |
| | lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) |
| | cul1a | Cullin 1a; Belongs to the cullin family. (777 aa) |
| | ppardb | Peroxisome proliferator-activated receptor delta b. (517 aa) |
| | rac3b | Rac family small GTPase 3b. (192 aa) |
| | rac3a | Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (192 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | tbl1xr1b | Tbl1x receptor 1b. (510 aa) |
| | ppp3r1a | Protein phosphatase 3, regulatory subunit B, alpha a. (170 aa) |
| | wnt8a | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | ror1 | Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (950 aa) |
| | prickle1b | Prickle homolog 1b. (863 aa) |
| | cul1b | Cullin 1b; Belongs to the cullin family. (775 aa) |
| | camk2d1 | Calcium/calmodulin-dependent protein kinase type II delta 1 chain; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system. (476 aa) |
| | wnt8-2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | Q1L8R8_DANRE | Mothers against decapentaplegic homolog. (571 aa) |
| | dvl1a | Dishevelled segment polarity protein 1a. (569 aa) |
| | nfatc3b | Nuclear factor of-activated T cells 3b. (923 aa) |
| | cby1 | Chibby homolog 1 (Drosophila). (125 aa) |
| | ppp3cca | Serine/threonine-protein phosphatase. (499 aa) |
| | wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa) |
| | rock2a | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa) |
| | prkcg | Protein kinase C, gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (654 aa) |
| | pparda | Peroxisome proliferator-activated receptor delta a. (496 aa) |
| | E7FFZ5_DANRE | Mothers against decapentaplegic homolog. (568 aa) |
| | notum2 | Carboxylesterase notum2; Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling. (495 aa) |
| | Rac1l | Si:ch211-1f22.1. (192 aa) |
| | fzd9a | Frizzled class receptor 9a; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa) |
| | tcf7 | Transcription factor 7. (355 aa) |
| | wnt7bb | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | ep300b | E1A-binding protein p300 b. (2615 aa) |
| | CTBP1 | Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa) |
| | cxxc4 | CXXC finger 4. (289 aa) |
| | csnk2a4 | Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (389 aa) |
| | axin2 | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1143 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | mapk10 | Mitogen-activated protein kinase. (472 aa) |
| | lrp6 | Low density lipoprotein receptor-related protein 6. (935 aa) |
| | prkacaa | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa) |
| | sox17 | SRY-box transcription factor 17. (413 aa) |
| | axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) |
| | crebbpa | CREB-binding protein a. (2349 aa) |
| | rspo1 | R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Belongs to the R-spondin family. (261 aa) |
| | prickle2b | Prickle homolog 2b. (840 aa) |
| | psen1 | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa) |
| | lgr4 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (971 aa) |
| | wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | rock2b | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa) |
| | prkcab | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (635 aa) |
| | nfatc2a | Nuclear factor of-activated T cells 2a. (894 aa) |
| | fzd4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa) |
| | ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) |
| | apc | APC regulator of WNT-signaling pathway. (2754 aa) |
| | ep300a | E1A-binding protein p300 a. (2679 aa) |
| | bambib | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (257 aa) |
| | crebbpb | CREB-binding protein b. (2431 aa) |
| | fzd6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa) |
| | ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) |
| | dvl3 | Dishevelled segment polarity protein 3b. (706 aa) |
| | nkd1 | Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family. (440 aa) |
| | camk2b | Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2. (388 aa) |
| | ctnnd2a | Catenin (cadherin-associated protein), delta 2a. (1221 aa) |
| | mapk8a | Mitogen-activated protein kinase. (427 aa) |
| | fzd1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa) |
| | ENSDARP00000148213 | PH_14 domain-containing protein. (208 aa) |
| | Ctbp2l | Uncharacterized protein. (531 aa) |
| | sfrp2l | Secreted frizzled-related protein 2-like. (333 aa) |
| | rhoac | Rho-related GTP-binding protein RhoA-C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | znrf3 | E3 ubiquitin-protein ligase znrf3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). Belongs to the ZNRF3 family. (866 aa) |
| | prkcaa | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
