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hey2 hey2 jag1b jag1b jag2b jag2b aph1b aph1b psen2 psen2 dla dla her6 her6 dlc dlc dvl2 dvl2 dlb dlb rbpja rbpja lfng lfng her12 her12 tle3a tle3a notch1b notch1b ncor2 ncor2 hdac1 hdac1 her15.2 her15.2 her15.1 her15.1 her2 her2 mfng mfng adam17a adam17a notch3 notch3 heyl heyl her9 her9 her4.4 her4.4 atxn1a atxn1a kat2b kat2b rbpjb rbpjb dvl3a dvl3a dld dld psenen psenen dll4 dll4 numb numb hey1 hey1 dvl1b dvl1b dtx4b dtx4b maml1 maml1 dtx4a dtx4a rfng rfng atxn1l atxn1l ctbp1 ctbp1 zgc:66440 zgc:66440 notch2 notch2 maml3 maml3 si:dkey-3h3.3 si:dkey-3h3.3 dvl1a dvl1a jag1a jag1a her4.2 her4.2 atxn1b atxn1b adam17b adam17b rbpjl rbpjl ep300b ep300b X1WG91_DANRE X1WG91_DANRE CTBP1 CTBP1 numbl numbl zgc:114200 zgc:114200 crebbpa crebbpa Dtx1 Dtx1 psen1 psen1 notch1a notch1a snw1 snw1 ep300a ep300a crebbpb crebbpb dvl3 dvl3 Ctbp2l Ctbp2l zmp:0000001236 zmp:0000001236 kat2a kat2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hey2Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. (324 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
jag2bDelta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa)
aph1bGamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). (258 aa)
psen2Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (441 aa)
dlaDelta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa)
her6Hairy-related 6. (270 aa)
dlcDelta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa)
dvl2Dishevelled segment polarity protein 2. (747 aa)
dlbDelta-like protein B; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. (615 aa)
rbpjaRecombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
lfngBeta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. (374 aa)
her12BHLH transcription factor. (155 aa)
tle3aTransducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa)
notch1bNotch receptor 1b. (2465 aa)
ncor2Nuclear receptor corepressor 2. (2315 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
her15.2Zgc:136520 protein. (149 aa)
her15.1Hairy and enhancer of split-related 15, tandem duplicate 1. (149 aa)
her2Hairy-related 2. (108 aa)
mfngBeta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. (360 aa)
adam17aADAM metallopeptidase domain 17a. (842 aa)
notch3Notch receptor 3. (2468 aa)
heylHairy/enhancer-of-split related with YRPW motif-like protein; Transcriptional repressor which functions as a downstream effector of Notch signaling. (310 aa)
her9BHLH-WRPW transcription factor. (291 aa)
her4.4Hairy-related 4, tandem duplicate 4. (152 aa)
atxn1aAtaxin 1a. (781 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
rbpjbRecombination signal-binding protein for immunoglobulin kappa J region b. (491 aa)
dvl3aDishevelled segment polarity protein 3a. (676 aa)
dldDelta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa)
psenenGamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa)
dll4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa)
numbNUMB endocytic adaptor protein. (680 aa)
hey1Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family. (317 aa)
dvl1bDishevelled segment polarity protein 1b. (716 aa)
dtx4bDeltex 4, E3 ubiquitin ligase b. (728 aa)
maml1Mastermind-like transcriptional coactivator 1. (1057 aa)
dtx4aDeltex 4, E3 ubiquitin ligase a. (704 aa)
rfngBeta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Regulates neurogenesis in the hindbrain; involved in boundary cell specification via Notch- mediated activation of wnt1 expression. (362 aa)
atxn1lAtaxin 1-like. (765 aa)
ctbp1C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (449 aa)
zgc:66440Zgc:66440. (384 aa)
notch2Notch receptor 2. (2475 aa)
maml3Mastermind-like transcriptional coactivator 3. (972 aa)
si:dkey-3h3.3Si:dkey-3h3.3. (441 aa)
dvl1aDishevelled segment polarity protein 1a. (569 aa)
jag1aProtein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)
her4.2Hairy-related 4, tandem duplicate 2. (152 aa)
atxn1bAtaxin 1b. (827 aa)
adam17bADAM metallopeptidase domain 17b. (843 aa)
rbpjlRecombination signal-binding protein for immunoglobulin kappa J region-like. (510 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
X1WG91_DANRESi:dkey-40c23.2. (967 aa)
CTBP1Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
numblNUMB-like endocytic adaptor protein. (618 aa)
zgc:114200Zgc:114200. (253 aa)
crebbpaCREB-binding protein a. (2349 aa)
Dtx1RING-type domain-containing protein. (306 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
snw1SNW domain-containing 1. (536 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
crebbpbCREB-binding protein b. (2431 aa)
dvl3Dishevelled segment polarity protein 3b. (706 aa)
Ctbp2lUncharacterized protein. (531 aa)
zmp:0000001236MamL-1 domain-containing protein. (892 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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