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prkacab prkacab csnk1da csnk1da smurf1 smurf1 gli2a gli2a smo smo csnk1db csnk1db gli2b gli2b fbxw11b fbxw11b prkacba prkacba arrb2b arrb2b ptch1 ptch1 spopla spopla gsk3ba gsk3ba kif7 kif7 mosmob mosmob dhh dhh smurf2 smurf2 shhb shhb cul3a cul3a csnk1g2a csnk1g2a arrb2a arrb2a gli3 gli3 csnk1e csnk1e ccnd2a ccnd2a gsk3bb gsk3bb ptch2 ptch2 gpr161 gpr161 mgrn1b mgrn1b ihha ihha ihhb ihhb prkacbb prkacbb hhip hhip cdon cdon gas1b gas1b csnk1g2b csnk1g2b ccnd2b ccnd2b boc boc spoplb spoplb arrb1 arrb1 kif3a kif3a cul1a cul1a mosmoa mosmoa megf8 megf8 cul1b cul1b bcl2a bcl2a bcl2b bcl2b shha shha E7FAM4_DANRE E7FAM4_DANRE lrp2b lrp2b gli1 gli1 spop spop lrp2a lrp2a cul3b cul3b mgrn1a mgrn1a sufu sufu prkacaa prkacaa csnk1g1 csnk1g1 ccnd1 ccnd1 gas1a gas1a grk3 grk3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
csnk1daCasein kinase I isoform delta-A; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (403 aa)
smurf1E3 ubiquitin-protein ligase. (731 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
csnk1dbCasein kinase I isoform delta-B; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (409 aa)
gli2bGLI family zinc finger 2b. (1225 aa)
fbxw11bF-box and WD repeat domain-containing 11b. (531 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
arrb2bArrestin, beta 2b. (408 aa)
ptch1Protein patched homolog 1. (1475 aa)
spoplaSpeckle-type POZ protein-like A; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family. (392 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
mosmobModulator of smoothened protein; Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. (167 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
smurf2E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (765 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
cul3aCullin 3a; Belongs to the cullin family. (774 aa)
csnk1g2aCasein kinase 1, gamma 2a; Belongs to the protein kinase superfamily. (418 aa)
arrb2aArrestin, beta 2a. (406 aa)
gli3GLI family zinc finger 3. (1553 aa)
csnk1eCasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (417 aa)
ccnd2aCyclin D2, a; Belongs to the cyclin family. (298 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
gpr161G-protein coupled receptor 161; Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle; [...] (526 aa)
mgrn1bMahogunin, ring finger 1b. (549 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
hhipHedgehog-interacting protein. (693 aa)
cdonCell adhesion molecule-related/down-regulated by oncogenes. (1125 aa)
gas1bGrowth arrest-specific 1b. (263 aa)
csnk1g2bCasein kinase 1, gamma 2b; Belongs to the protein kinase superfamily. (444 aa)
ccnd2bCyclin D2, b; Belongs to the cyclin family. (295 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
spoplbSpeckle-type POZ protein-like B; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency; Belongs to the Tdpoz family. (392 aa)
arrb1Arrestin, beta 1. (418 aa)
kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
cul1aCullin 1a; Belongs to the cullin family. (777 aa)
mosmoaUncharacterized protein. (167 aa)
megf8Multiple EGF-like-domains 8. (2870 aa)
cul1bCullin 1b; Belongs to the cullin family. (775 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
bcl2bBCL2 apoptosis regulator b. (209 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
E7FAM4_DANRESi:ch211-237c6.4; Belongs to the G-protein coupled receptor 1 family. (524 aa)
lrp2bLow density lipoprotein receptor-related protein 2b. (4602 aa)
gli1GLI family zinc finger 1. (1404 aa)
spopSpeckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Belongs to the Tdpoz family. (374 aa)
lrp2aLow density lipoprotein receptor-related protein 2a. (4673 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
mgrn1aProbable E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Acts also as a negative regulator of hedgehog signaling. (529 aa)
sufuSuppressor of fused homolog. (485 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
csnk1g1Casein kinase I isoform gamma-1; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). (421 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
gas1aGrowth arrest-specific 1a. (270 aa)
grk3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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