STRINGSTRING
zgc:65894 zgc:65894 prkacab prkacab csnk1da csnk1da drd2b drd2b htr2cl1 htr2cl1 map2k1 map2k1 tuba8l5 tuba8l5 csnk1db csnk1db map2k2a map2k2a hrasb hrasb tuba1a tuba1a gnaq gnaq prkg3 prkg3 tubb2 tubb2 zgc:55558 zgc:55558 cx36.7 cx36.7 prkacba prkacba prkg1a prkg1a prkcba prkcba tuba8l4 tuba8l4 itpr1b itpr1b gnai1 gnai1 mapk1 mapk1 prkcbb prkcbb tuba8l2 tuba8l2 tubb4b tubb4b gna11b gna11b gnai3 gnai3 map2k5 map2k5 E7F244_DANRE E7F244_DANRE tubb5 tubb5 nras nras drd1b drd1b zgc:55461 zgc:55461 cx43 cx43 tuba8l tuba8l tuba2 tuba2 egf egf pdgfc pdgfc tubb1 tubb1 prkg2 prkg2 tuba1c tuba1c gucy1b2 gucy1b2 prkacbb prkacbb raf1b raf1b adcy2a adcy2a sos2 sos2 adcy6a adcy6a adcy8 adcy8 plcb3 plcb3 adcy1a adcy1a gucy1a1 gucy1a1 tuba8l3 tuba8l3 src src pdgfra pdgfra mapk3 mapk3 gjd2b gjd2b pdgfaa pdgfaa drd1a drd1a tuba4l tuba4l pdgfd pdgfd adcy3a adcy3a tuba1b tuba1b Plcb2 Plcb2 gucy1b1 gucy1b1 gnai2a gnai2a adcy1b adcy1b cdk1 cdk1 adrb1 adrb1 adcy5 adcy5 htr2aa htr2aa Q5RHR2_DANRE Q5RHR2_DANRE adcy6b adcy6b adcy2b adcy2b gnaia gnaia GUCY1A2 GUCY1A2 grb2b grb2b grm1a grm1a prkcg prkcg drd2a drd2a map2k2b map2k2b cx40.8 cx40.8 egfra egfra map3k2 map3k2 htr2ab htr2ab drd2l drd2l gnai2b gnai2b itpr2 itpr2 E7FC63_DANRE E7FC63_DANRE raf1a raf1a zgc:153426 zgc:153426 grm5b grm5b ENSDARP00000132437 ENSDARP00000132437 tuba7l tuba7l itpr3 itpr3 grb2a grb2a PLCB4 PLCB4 prkacaa prkacaa adcy9 adcy9 tubb2b tubb2b prkcab prkcab pdgfab pdgfab tubb6 tubb6 grm1b grm1b lpar1 lpar1 hrasa hrasa sos1 sos1 grm5a grm5a pdgfba pdgfba pdgfbb pdgfbb htr2b htr2b ENSDARP00000148213 ENSDARP00000148213 prkg1b prkg1b itpr1a itpr1a pdgfrb pdgfrb gjd1a gjd1a prkcaa prkcaa tjp1a tjp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
zgc:65894Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
csnk1daCasein kinase I isoform delta-A; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (403 aa)
drd2bDopamine D2c receptor; Belongs to the G-protein coupled receptor 1 family. (452 aa)
htr2cl15-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1. (518 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
tuba8l5Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (477 aa)
csnk1dbCasein kinase I isoform delta-B; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (409 aa)
map2k2aMitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
hrasb-Ha-ras Harvey rat sarcoma viral oncogene homolog, like. (189 aa)
tuba1aTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
gnaqGuanine nucleotide-binding protein (G protein), q polypeptide. (359 aa)
prkg3Si:dkey-121j17.5. (571 aa)
tubb2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
zgc:55558Zgc:55558 protein. (187 aa)
cx36.7Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (362 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
prkg1acGMP-dependent protein kinase. (667 aa)
prkcbaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
tuba8l4Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
itpr1bInositol 1,4,5-trisphosphate receptor, type 1b. (2782 aa)
gnai1Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1. (354 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
prkcbbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa)
tuba8l2Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
tubb4bTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
gna11bGuanine nucleotide-binding protein (G protein), alpha 11b (Gq class). (359 aa)
gnai3Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 3. (354 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (450 aa)
E7F244_DANRETubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
tubb5Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
nrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa)
drd1bDopamine receptor D1b; Belongs to the G-protein coupled receptor 1 family. (446 aa)
zgc:55461Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
cx43Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)
tuba8lTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
tuba2Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
egfEpidermal growth factor. (1114 aa)
pdgfcPlatelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (343 aa)
tubb1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
prkg2cGMP-dependent protein kinase. (768 aa)
tuba1cTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
gucy1b2Guanylate cyclase 1, soluble, beta 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (757 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
raf1bRaf-1 proto-oncogene, serine/threonine kinase b. (629 aa)
adcy2aAdenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1151 aa)
sos2Son of sevenless homolog 2 (Drosophila). (1341 aa)
adcy6aAdenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (892 aa)
plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa)
adcy1aAdenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
gucy1a1Soluble guanylate cyclase large subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (679 aa)
tuba8l3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
gjd2bGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)
pdgfaaPlatelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa)
drd1aDopamine receptor D1a; Belongs to the G-protein coupled receptor 1 family. (363 aa)
tuba4lTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
pdgfdPlatelet-derived growth factor d. (372 aa)
adcy3aAdenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
tuba1bTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
Plcb2Phosphoinositide phospholipase C. (694 aa)
gucy1b1Soluble guanylate cyclase small subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (608 aa)
gnai2aGuanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like. (355 aa)
adcy1bAdenylate cyclase 1b; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (834 aa)
cdk1Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa)
adrb1Adrenergic, beta-1-, receptor. (390 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1186 aa)
htr2aa5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (402 aa)
Q5RHR2_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa)
adcy6bAdenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
adcy2bAdenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1139 aa)
gnaiaGuanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a. (377 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (631 aa)
grb2bGrowth factor receptor-bound protein 2b. (217 aa)
grm1aGlutamate receptor, metabotropic 1a. (1153 aa)
prkcgProtein kinase C, gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (654 aa)
drd2aDopamine D2a receptor; Belongs to the G-protein coupled receptor 1 family. (448 aa)
map2k2bMitogen-activated protein kinase kinase 2b; Belongs to the protein kinase superfamily. (395 aa)
cx40.8Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (354 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
map3k2Mitogen-activated protein kinase kinase kinase 2. (623 aa)
htr2ab5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b. (458 aa)
drd2lDopamine receptor D2-like; Belongs to the G-protein coupled receptor 1 family. (450 aa)
gnai2bGuanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b. (355 aa)
itpr2Inositol 1,4,5-trisphosphate receptor, type 2. (2008 aa)
E7FC63_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1183 aa)
raf1aRaf-1 proto-oncogene, serine/threonine kinase a. (654 aa)
zgc:153426Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
grm5bGlutamate receptor, metabotropic 5b. (1195 aa)
ENSDARP00000132437Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (340 aa)
tuba7lTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
itpr3Inositol 1,4,5-trisphosphate receptor, type 3. (2634 aa)
grb2aGrowth factor receptor-bound protein 2a. (217 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1143 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
adcy9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1364 aa)
tubb2bTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
prkcabProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (635 aa)
pdgfabPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
tubb6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
grm1bGlutamate receptor, metabotropic 1b. (1158 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (280 aa)
hrasaHRas proto-oncogene, GTPase a. (189 aa)
sos1Son of sevenless homolog 1 (Drosophila). (714 aa)
grm5aGlutamate receptor, metabotropic 5a. (1173 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (443 aa)
ENSDARP00000148213PH_14 domain-containing protein. (208 aa)
prkg1bcGMP-dependent protein kinase. (684 aa)
itpr1aInositol 1,4,5-trisphosphate receptor, type 1a. (2745 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1072 aa)
gjd1aGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (299 aa)
prkcaaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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