STRINGSTRING
stat1b stat1b map3k7 map3k7 ctsk ctsk map2k1 map2k1 mapk12a mapk12a mapk8b mapk8b chuk chuk ripk1l ripk1l tlr3 tlr3 map2k2a map2k2a nfkbiab nfkbiab stat1a stat1a pik3cd pik3cd tab2 tab2 mapk12b mapk12b myd88 myd88 akt2 akt2 tnfa tnfa ikbkg ikbkg tlr4bb tlr4bb ifnphi1 ifnphi1 mapk11 mapk11 mapk14b mapk14b traf6 traf6 mapk1 mapk1 traf3 traf3 pik3r3b pik3r3b mapk14a mapk14a fosab fosab zgc:171775 zgc:171775 map2k7 map2k7 tlr2 tlr2 pik3r1 pik3r1 fosaa fosaa jun jun ikbke ikbke mapk13 mapk13 map3k8 map3k8 zmp:0000001127 zmp:0000001127 mapk3 mapk3 casp8 casp8 rac1a rac1a tlr4al tlr4al mapk9 mapk9 tlr8b tlr8b il12ba il12ba map2k4b map2k4b tirap tirap tlr4ba tlr4ba F1QP65_DANRE F1QP65_DANRE tlr7 tlr7 map2k4a map2k4a rac1b rac1b tlr8a tlr8a nfkbiaa nfkbiaa akt3b akt3b cd40 cd40 cxcl11.7 cxcl11.7 ikbkb ikbkb irak1 irak1 crfb2 crfb2 cxcl11.8 cxcl11.8 tlr5a tlr5a tlr5b tlr5b tlr18 tlr18 map2k2b map2k2b Rac1l Rac1l irf3 irf3 pik3cb pik3cb il12a il12a ticam1 ticam1 pik3r2 pik3r2 il6 il6 akt1 akt1 tbk1 tbk1 rela rela ENSDARP00000133721 ENSDARP00000133721 mapk10 mapk10 cxcl11.1 cxcl11.1 irak4 irak4 cxcl19 cxcl19 nfkb1 nfkb1 irf5 irf5 casp22 casp22 cxcl11.5 cxcl11.5 cxcl8a cxcl8a pik3ca pik3ca tlr1 tlr1 akt3a akt3a fadd fadd akt2l akt2l il1b il1b tollip tollip map2k6 map2k6 mapk8a mapk8a tlr9 tlr9 LOC101883994 LOC101883994
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stat1bSignal transducer and activator of transcription. (725 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (551 aa)
ctskCathepsin K; Belongs to the peptidase C1 family. (333 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
mapk12aMitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAP [...] (363 aa)
mapk8bMitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
ripk1lReceptor (TNFRSF)-interacting serine-threonine kinase 1,-like. (661 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
map2k2aMitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. (711 aa)
mapk12bMitogen-activated protein kinase. (364 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
ikbkgInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (586 aa)
tlr4bbToll-like receptor 4b, duplicate b. (819 aa)
ifnphi1Interferon phi 1. (185 aa)
mapk11Mitogen-activated protein kinase. (361 aa)
mapk14bMitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
pik3r3bPhosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (464 aa)
mapk14aMitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
zgc:171775Mitogen-activated protein kinase. (359 aa)
map2k7Mitogen-activated protein kinase kinase 7. (438 aa)
tlr2Toll-like receptor 2. (788 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
fosaaV-fos FBJ murine osteosarcoma viral oncogene homolog Aa. (352 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
ikbkeInhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
mapk13Mitogen-activated protein kinase. (362 aa)
map3k8Mitogen-activated protein kinase kinase kinase 8. (472 aa)
zmp:0000001127Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (187 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
rac1aRas-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
tlr4alToll-like receptor 4a, like. (816 aa)
mapk9Mitogen-activated protein kinase. (421 aa)
tlr8bToll-like receptor 8b. (802 aa)
il12baInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (350 aa)
map2k4bMitogen-activated protein kinase kinase 4B; Belongs to the protein kinase superfamily. (417 aa)
tirapToll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (203 aa)
tlr4baToll-like receptor 4b, duplicate a. (787 aa)
F1QP65_DANRESi:ch211-153j24.3. (329 aa)
tlr7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1045 aa)
map2k4aMitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa)
rac1bRas-related C3 botulinum toxin substrate 1-like protein. (192 aa)
tlr8aToll-like receptor 8a; Belongs to the Toll-like receptor family. (1009 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
cxcl11.7C-X-C motif chemokine. (121 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
irak1Interleukin-1 receptor-associated kinase 1. (686 aa)
crfb2Cytokine receptor family member b2. (469 aa)
cxcl11.8Chemokine (C-X-C motif) ligand 11, duplicate 8. (102 aa)
tlr5aToll-like receptor 5a; Belongs to the Toll-like receptor family. (881 aa)
tlr5bToll-like receptor 5b; Belongs to the Toll-like receptor family. (881 aa)
tlr18Toll-like receptor 18. (854 aa)
map2k2bMitogen-activated protein kinase kinase 2b; Belongs to the protein kinase superfamily. (395 aa)
Rac1lSi:ch211-1f22.1. (192 aa)
irf3Interferon regulatory factor 3. (426 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa)
il12aInterleukin 12a. (196 aa)
ticam1Toll-like receptor adaptor molecule 1. (566 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
tbk1TANK-binding kinase 1. (727 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
ENSDARP00000133721IG domain-containing protein. (280 aa)
mapk10Mitogen-activated protein kinase. (472 aa)
cxcl11.1C-X-C motif chemokine 11-1; Ligand for cxcr3.2. Chemotactic for macrophages. (94 aa)
irak4Interleukin-1 receptor-associated kinase 4. (447 aa)
cxcl19Chemokine (C-X-C motif) ligand 19. (101 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
irf5Interferon regulatory factor 5. (516 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
cxcl11.5Chemokine (C-X-C motif) ligand 11, duplicate 5. (106 aa)
cxcl8aInterleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
akt2lV-akt murine thymoma viral oncogene homolog 2,-like. (478 aa)
il1bInterleukin-1. (284 aa)
tollipToll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (276 aa)
map2k6Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] (363 aa)
mapk8aMitogen-activated protein kinase. (427 aa)
tlr9Toll-like receptor 9; Belongs to the Toll-like receptor family. (1069 aa)
LOC101883994SCY domain-containing protein. (134 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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