STRINGSTRING
ppp1caa ppp1caa rhocb rhocb pip4k2aa pip4k2aa arpc1a arpc1a waslb waslb cfl1l cfl1l cfl2 cfl2 fgf20a fgf20a bdkrb1 bdkrb1 map2k1 map2k1 zgc:158689 zgc:158689 fgf1a fgf1a pip5k1bb pip5k1bb fgf6a fgf6a fgfr3 fgfr3 itga2b itga2b fgfr1a fgfr1a pip5k1ab pip5k1ab rras rras itgb3a itgb3a si:dkey-32n7.4 si:dkey-32n7.4 map2k2a map2k2a hrasb hrasb msna msna pik3cd pik3cd rhoab rhoab fgf8a fgf8a mylkb mylkb pak4 pak4 limk1b limk1b zgc:55558 zgc:55558 mylpfb mylpfb cfl1 cfl1 itgb3b itgb3b arpc5b arpc5b gsna gsna itga5 itga5 itgb4 itgb4 gna13b gna13b kng1 kng1 itgb1b.2 itgb1b.2 crkl crkl arpc1b arpc1b mapk1 mapk1 itgb1a itgb1a myl7 myl7 pik3r3b pik3r3b arhgef12a arhgef12a rhoaa rhoaa myh11a myh11a pip4k2ca pip4k2ca ptk2ab ptk2ab itgav itgav itga9 itga9 scin scin pak2b pak2b mylka mylka gsnb gsnb braf braf fgf10a fgf10a gna12a gna12a ins ins fgf5 fgf5 itga11a itga11a rras2 rras2 pfn2l pfn2l cxcl12a cxcl12a fgf24 fgf24 actb1 actb1 itga3a itga3a myl9a myl9a nras nras pik3r1 pik3r1 arpc5a arpc5a arhgef4 arhgef4 git1 git1 fgf8b fgf8b cdc42l cdc42l itga8 itga8 pip5k1ca pip5k1ca arpc5la arpc5la cxcr4b cxcr4b brk1 brk1 fgf16 fgf16 lpar2a lpar2a lpar2b lpar2b fgf1b fgf1b si:dkey-63b1.1 si:dkey-63b1.1 fgf18b fgf18b pip5k1ba pip5k1ba itgb7 itgb7 cyfip1 cyfip1 abi2b abi2b itgb6 itgb6 fgf23 fgf23 fgf6b fgf6b ppp1r12c ppp1r12c egf egf pdgfc pdgfc fgfr1b fgfr1b mylpfa mylpfa tmsb tmsb cxcl12b cxcl12b crk crk ezrb ezrb itgb5 itgb5 cxcr4a cxcr4a arpc3 arpc3 arpc4l arpc4l scinlb scinlb raf1b raf1b F2R F2R f2r f2r arhgap35b arhgap35b sos2 sos2 pxnb pxnb NCKAP1L NCKAP1L baiap2a baiap2a spata13 spata13 apc2 apc2 myh9b myh9b ppp1cab ppp1cab limk2 limk2 slc9a1b slc9a1b arpc2 arpc2 chrm5b chrm5b mos mos itga6b itga6b src src zgc:86896 zgc:86896 pdgfra pdgfra wasla wasla mapk3 mapk3 LOC100536197 LOC100536197 tmsb4x tmsb4x pfn2 pfn2 pdgfaa pdgfaa itga3b itga3b rac1a rac1a itga6a itga6a E7EZK3_DANRE E7EZK3_DANRE iqgap1 iqgap1 vav3b vav3b vclb vclb arhgef7b arhgef7b pdgfd pdgfd tiam1a tiam1a gna13a gna13a mylk3 mylk3 fgf22 fgf22 fgf9 fgf9 wasf2 wasf2 myl9b myl9b msnb msnb vcla vcla rac1b rac1b bcar1 bcar1 F2R-2 F2R-2 fgf18a fgf18a rac2 rac2 fgf20b fgf20b F2R-3 F2R-3 ezra ezra F2R-4 F2R-4 pfn1 pfn1 F2R-5 F2R-5 ppp1cb ppp1cb rac3b rac3b pip4k2cb pip4k2cb rac3a rac3a fn1a fn1a diaph2 diaph2 pak6b pak6b tmsb2 tmsb2 itga1 itga1 insb insb mylk2 mylk2 myl2b myl2b LOC569566 LOC569566 myl12.2 myl12.2 ppp1r12a ppp1r12a itga2.2 itga2.2 arpc5lb arpc5lb araf araf itga10 itga10 arhgef1b arhgef1b iqgap2 iqgap2 actb2 actb2 fgf7 fgf7 rock2a rock2a actn1 actn1 cdc42l2 cdc42l2 itgb1b.1 itgb1b.1 gng12a gng12a MRAS MRAS myh9a myh9a itgb2 itgb2 fgfr2 fgfr2 itga6l itga6l map2k2b map2k2b pikfyve pikfyve cyfip2 cyfip2 egfra egfra F2R-6 F2R-6 myh10 myh10 Rac1l Rac1l chrm3b chrm3b itga11b itga11b arhgap35a arhgap35a X1WCU6_DANRE X1WCU6_DANRE itgae.2 itgae.2 pik3cb pik3cb chrm4b chrm4b mylk4a mylk4a ssh2a ssh2a cdc42 cdc42 Vav3 Vav3 ssh1a ssh1a chrm3a chrm3a pik3r2 pik3r2 pip5k1aa pip5k1aa chrm5a chrm5a raf1a raf1a ppp1cbl ppp1cbl iqgap3 iqgap3 ssh2b ssh2b itga4 itga4 pak1 pak1 fgf3 fgf3 limk1a limk1a fgf2 fgf2 ENSDARP00000133096 ENSDARP00000133096 myl2a myl2a pak7 pak7 chrm2a chrm2a myl10 myl10 fgf19 fgf19 fgf4 fgf4 pip5k1cb pip5k1cb itgb1b itgb1b pak2a pak2a rock2b rock2b myl12.1 myl12.1 fgf17 fgf17 baiap2b baiap2b scinla scinla pik3ca pik3ca apc apc arhgef12b arhgef12b pdgfab pdgfab fgf10b fgf10b fgf21 fgf21 lpar1 lpar1 rock1 rock1 ppp1cc ppp1cc hrasa hrasa chrm1a chrm1a sos1 sos1 chrm4a chrm4a vav2 vav2 mras mras fgfr4 fgfr4 lpar4 lpar4 Zmp:0000001167 Zmp:0000001167 pdgfba pdgfba pdgfbb pdgfbb arhgef7a arhgef7a pxna pxna ssh1b ssh1b actn4 actn4 rhoac rhoac pdgfrb pdgfrb itgb8 itgb8 Itga7 Itga7 LOC101882228 LOC101882228 nckap1 nckap1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ppp1caaSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
rhocbRho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
pip4k2aaSimilar to type II phosphatidylinositolphosphate kinase-alpha. (404 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
waslbWASP-like actin nucleation-promoting factor b. (518 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
bdkrb1Bradykinin receptor B1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
zgc:158689Zgc:158689. (606 aa)
fgf1aPutative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa)
pip5k1bbPhosphatidylinositol-4-phosphate 5-kinase, type I, beta b. (527 aa)
fgf6aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
itga2bIntegrin, alpha 2b (Platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); Belongs to the integrin alpha chain family. (1037 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
pip5k1abPhosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b. (584 aa)
rrasRelated RAS viral (R-ras) oncogene homolog. (196 aa)
itgb3aIntegrin beta; Belongs to the integrin beta chain family. (785 aa)
si:dkey-32n7.4Si:dkey-32n7.4; Belongs to the integrin alpha chain family. (1136 aa)
map2k2aMitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
hrasb-Ha-ras Harvey rat sarcoma viral oncogene homolog, like. (189 aa)
msnaMoesin a. (579 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
mylkbMyosin light chain kinase b. (966 aa)
pak4Non-specific serine/threonine protein kinase. (664 aa)
limk1bLIM domain kinase 1b. (615 aa)
zgc:55558Zgc:55558 protein. (187 aa)
mylpfbMyosin light chain, phosphorylatable, fast skeletal muscle b. (170 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
itgb3bIntegrin beta; Belongs to the integrin beta chain family. (790 aa)
arpc5bActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
gsnaGelsolin a. (729 aa)
itga5Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa)
itgb4Integrin beta. (1893 aa)
gna13bGuanine nucleotide-binding protein (G protein), alpha 13b. (377 aa)
kng1Kininogen 1. (331 aa)
itgb1b.2Integrin beta; Belongs to the integrin beta chain family. (613 aa)
crklV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (305 aa)
arpc1bActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
itgb1aIntegrin beta; Belongs to the integrin beta chain family. (798 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
pik3r3bPhosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (464 aa)
arhgef12aRho guanine nucleotide exchange factor (GEF) 12a. (1357 aa)
rhoaaRho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
myh11aMyosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
pip4k2caPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2). (417 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
itgavIntegrin, alpha V; Belongs to the integrin alpha chain family. (1045 aa)
itga9Integrin, alpha 9; Belongs to the integrin alpha chain family. (1032 aa)
scinScinderin. (733 aa)
pak2bNon-specific serine/threonine protein kinase. (537 aa)
mylkaMyosin, light chain kinase a. (899 aa)
gsnbGelsolin b. (728 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (817 aa)
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
gna12aGuanine nucleotide-binding protein (G protein) alpha 12a. (385 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
itga11aIntegrin, alpha 11a; Belongs to the integrin alpha chain family. (1190 aa)
rras2Related RAS viral (R-ras) oncogene homolog 2. (202 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
fgf24Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
actb1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
itga3aIntegrin, alpha 3a; Belongs to the integrin alpha chain family. (1053 aa)
myl9aMyosin, light chain 9a, regulatory. (174 aa)
nrasGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
arpc5aActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
arhgef4Rho guanine nucleotide exchange factor (GEF) 4. (3063 aa)
git1G protein-coupled receptor kinase-interacting ArfGAP 1. (752 aa)
fgf8bFibroblast growth factor 8b; May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system. (212 aa)
cdc42lCell division cycle 42,-like. (191 aa)
itga8Integrin, alpha 8; Belongs to the integrin alpha chain family. (1059 aa)
pip5k1caPhosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (682 aa)
arpc5laActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
brk1Probable protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity); Belongs to the BRK1 family. (83 aa)
fgf16Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa)
lpar2aLysophosphatidic acid receptor 2a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
lpar2bLysophosphatidic acid receptor 2b; Belongs to the G-protein coupled receptor 1 family. (369 aa)
fgf1bMultifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa)
si:dkey-63b1.1Si:dkey-63b1.1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
fgf18bFibroblast growth factor 18b; Belongs to the heparin-binding growth factors family. (213 aa)
pip5k1baPhosphatidylinositol-4-phosphate 5-kinase, type I, beta a. (521 aa)
itgb7Integrin beta; Belongs to the integrin beta chain family. (754 aa)
cyfip1Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family. (1253 aa)
abi2bAbl-interactor 2b. (461 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (782 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (258 aa)
fgf6bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ppp1r12cProtein phosphatase 1, regulatory subunit 12C. (672 aa)
egfEpidermal growth factor. (1114 aa)
pdgfcPlatelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (343 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
tmsbThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family. (45 aa)
cxcl12bChemokine (C-X-C motif) ligand 12B (Stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (97 aa)
crkV-crk sarcoma virus CT10 oncogene homolog (Avian). (311 aa)
ezrbEzrin b. (583 aa)
itgb5Integrin beta; Belongs to the integrin beta chain family. (823 aa)
cxcr4aChemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
arpc4lActin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
scinlbScinderin-like b. (720 aa)
raf1bRaf-1 proto-oncogene, serine/threonine kinase b. (629 aa)
F2RSi:dkey-163m14.2. (462 aa)
f2rCoagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
arhgap35bRho GTPase-activating protein 35b. (1517 aa)
sos2Son of sevenless homolog 2 (Drosophila). (1341 aa)
pxnbPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (525 aa)
NCKAP1LZgc:172352. (1123 aa)
baiap2aBAR/IMD domain-containing adaptor protein 2a. (514 aa)
spata13Spermatogenesis-associated 13. (1251 aa)
apc2APC regulator of WNT-signaling pathway 2. (2105 aa)
myh9bMyosin, heavy chain 9b, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1749 aa)
ppp1cabSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
limk2LIM domain kinase 2. (651 aa)
slc9a1bSodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (653 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
chrm5bMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (457 aa)
mosV-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (329 aa)
itga6bIntegrin, alpha 6b; Belongs to the integrin alpha chain family. (1085 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
zgc:86896Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (357 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
waslaWASP-like actin nucleation-promoting factor a. (502 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
LOC100536197Non-specific serine/threonine protein kinase. (693 aa)
tmsb4xThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
pdgfaaPlatelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa)
itga3bIntegrin, alpha 3b; Belongs to the integrin alpha chain family. (1041 aa)
rac1aRas-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
itga6aIntegrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa)
E7EZK3_DANRESi:ch211-203d1.3. (607 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
vav3bVav 3 guanine nucleotide exchange factor b. (826 aa)
vclbVinculin b. (987 aa)
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b. (799 aa)
pdgfdPlatelet-derived growth factor d. (372 aa)
tiam1aTIAM Rac1-associated GEF 1a. (1621 aa)
gna13aGuanine nucleotide-binding protein (G protein), alpha 13a. (376 aa)
mylk3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart. (716 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
wasf2WASP family member 2. (486 aa)
myl9bMyosin, light polypeptide 9, regulatory. (173 aa)
msnbMoesin b. (577 aa)
vclaVinculin a. (1131 aa)
rac1bRas-related C3 botulinum toxin substrate 1-like protein. (192 aa)
bcar1BCAR1 scaffold protein, Cas family member. (919 aa)
F2R-2Si:dkey-163m14.7. (393 aa)
fgf18aFibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
rac2Rac family small GTPase 2. (219 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
F2R-3Si:dkey-163m14.4. (438 aa)
ezraEzrl protein. (595 aa)
F2R-4Si:dkey-163m14.10. (371 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
F2R-5Si:dkey-163m14.6. (411 aa)
ppp1cbSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
rac3bRac family small GTPase 3b. (192 aa)
pip4k2cbPhosphatidylinositol-5-phosphate 4-kinase, type II, gamma b. (416 aa)
rac3aRas-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (192 aa)
fn1aFibronectin 1a. (2480 aa)
diaph2Diaphanous-related formin 2. (1077 aa)
pak6bNon-specific serine/threonine protein kinase. (607 aa)
tmsb2Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
itga1Integrin, alpha 1; Belongs to the integrin alpha chain family. (1187 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
mylk2Myosin light chain kinase 2. (777 aa)
myl2bMyosin, light polypeptide 2, regulatory, cardiac, slow. (168 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
myl12.2Myosin, light chain 12, genome duplicate 2. (172 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
itga2.2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2; Belongs to the integrin alpha chain family. (1197 aa)
arpc5lbActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
arafA-Raf proto-oncogene, serine/threonine kinase. (604 aa)
itga10Integrin, alpha 10; Belongs to the integrin alpha chain family. (1174 aa)
arhgef1bRho guanine nucleotide exchange factor (GEF) 1b. (1005 aa)
iqgap2IQ motif-containing GTPase-activating protein 2. (1680 aa)
actb2Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
actn1Actinin, alpha 1. (902 aa)
cdc42l2Cell division cycle 42-like 2. (209 aa)
itgb1b.1Integrin beta; Belongs to the integrin beta chain family. (787 aa)
gng12aGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (76 aa)
MRASSi:ch73-116o1.2. (208 aa)
myh9aMyosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
itgb2Integrin beta. (768 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
itga6lIntegrin, alpha 6,-like; Belongs to the integrin alpha chain family. (1035 aa)
map2k2bMitogen-activated protein kinase kinase 2b; Belongs to the protein kinase superfamily. (395 aa)
pikfyvePhosphatidylinositol phosphate 5-kinase type III isoform d. (2075 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
F2R-6Zgc:171965. (391 aa)
myh10Myosin, heavy chain 10, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1992 aa)
Rac1lSi:ch211-1f22.1. (192 aa)
chrm3bMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (494 aa)
itga11bIntegrin, alpha 11b; Belongs to the integrin alpha chain family. (1218 aa)
arhgap35aRho GTPase-activating protein 35a. (1536 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
itgae.2Integrin, alpha E, tandem duplicate 2; Belongs to the integrin alpha chain family. (938 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa)
chrm4bMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (451 aa)
mylk4aMyosin light chain kinase family, member 4a. (572 aa)
ssh2aSlingshot protein phosphatase 2a. (1168 aa)
cdc42Cell division cycle 42. (191 aa)
Vav3Si:ch73-383g2.1. (253 aa)
ssh1aSlingshot protein phosphatase 1a. (671 aa)
chrm3aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (595 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
pip5k1aaPhosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a. (559 aa)
chrm5aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (490 aa)
raf1aRaf-1 proto-oncogene, serine/threonine kinase a. (654 aa)
ppp1cblSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (231 aa)
iqgap3IQ motif-containing GTPase-activating protein 3. (1639 aa)
ssh2bSlingshot protein phosphatase 2b. (1016 aa)
itga4Integrin alpha 4; Belongs to the integrin alpha chain family. (1018 aa)
pak1Non-specific serine/threonine protein kinase. (587 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
limk1aLIM domain kinase 1a. (648 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
ENSDARP00000133096Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
myl2aMyosin, light chain 2a, regulatory, cardiac, slow. (169 aa)
pak7P21 protein (Cdc42/Rac)-activated kinase 7. (645 aa)
chrm2aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (495 aa)
myl10Myosin, light chain 10, regulatory. (167 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
pip5k1cbPhosphatidylinositol-4-phosphate 5-kinase, type I, gamma b. (697 aa)
itgb1bIntegrin beta; Belongs to the integrin beta chain family. (521 aa)
pak2aNon-specific serine/threonine protein kinase. (518 aa)
rock2bRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
myl12.1Myosin, light chain 12, genome duplicate 1. (172 aa)
fgf17Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family. (215 aa)
baiap2bBAR/IMD domain-containing adaptor protein 2b. (401 aa)
scinlaScinderin-like a. (720 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
arhgef12bRho guanine nucleotide exchange factor (GEF) 12b. (1419 aa)
pdgfabPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
fgf10bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
fgf21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (194 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (280 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
hrasaHRas proto-oncogene, GTPase a. (189 aa)
chrm1aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (465 aa)
sos1Son of sevenless homolog 1 (Drosophila). (714 aa)
chrm4aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (513 aa)
vav2Vav 2 guanine nucleotide exchange factor. (875 aa)
mrasMuscle RAS oncogene homolog. (209 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
lpar4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
Zmp:0000001167ANK_REP_REGION domain-containing protein. (136 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
arhgef7aRho guanine nucleotide exchange factor (GEF) 7a. (859 aa)
pxnaPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (532 aa)
ssh1bSlingshot protein phosphatase 1b. (835 aa)
actn4Actinin, alpha 4. (923 aa)
rhoacRho-related GTP-binding protein RhoA-C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1072 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (668 aa)
Itga7Uncharacterized protein. (156 aa)
LOC101882228FH2 domain-containing protein. (287 aa)
nckap1Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). (1134 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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