STRINGSTRING
stat1b stat1b ppp1caa ppp1caa cd74a cd74a srsf9 srsf9 syk syk eif2b1 eif2b1 map3k7 map3k7 casp3a casp3a hcfc1a hcfc1a apaf1 apaf1 M9MM93_DANRE M9MM93_DANRE tnfb tnfb tnfrsf1a tnfrsf1a chuk chuk ifih1 ifih1 itgb3a itgb3a tlr3 tlr3 nfkbiab nfkbiab stat1a stat1a eif2b3 eif2b3 pik3cd pik3cd tab2 tab2 myd88 myd88 srsf6b srsf6b akt2 akt2 baxa baxa itgb3b itgb3b pdia7 pdia7 tnfa tnfa eif2s1a eif2s1a ikbkg ikbkg itga5 itga5 bcl2l1 bcl2l1 tap2a tap2a srpk1a srpk1a ifnphi1 ifnphi1 cycsb cycsb tsc1a tsc1a srsf3a srsf3a cgas cgas traf6 traf6 jak1 jak1 traf3 traf3 socs3a socs3a pik3r3b pik3r3b srpk1b srpk1b srsf5a srsf5a traf2a traf2a ptpn11b ptpn11b casp9 casp9 mhc2a mhc2a stat2 stat2 tradd tradd c3a.3 c3a.3 c3a.1 c3a.1 mhc1zba mhc1zba tlr2 tlr2 pik3r1 pik3r1 rhebl1 rhebl1 eif2b2 eif2b2 eif4ebp1 eif4ebp1 eif2s1b eif2s1b b2m b2m badb badb casp3b casp3b nxf1 nxf1 fas fas ikbke ikbke srsf2a srsf2a srsf1a srsf1a ptpn11a ptpn11a nectin1b nectin1b mavs mavs ppp1cab ppp1cab c5 c5 card9 card9 zmp:0000001127 zmp:0000001127 calr calr src src srsf6a srsf6a casp8 casp8 tapbp.1 tapbp.1 socs3b socs3b eif2b5 eif2b5 mhc2dab mhc2dab il12ba il12ba znf1007 znf1007 nectin1a nectin1a ifngr1l ifngr1l birc2 birc2 jak2b jak2b daxx daxx mtor mtor eif2b4 eif2b4 rheb rheb c3a.2 c3a.2 b2ml b2ml ppp1cb ppp1cb zgc:153681 zgc:153681 nfkbiaa nfkbiaa bada bada mhc2dcb mhc2dcb akt3b akt3b eif2ak1 eif2ak1 tp53 tp53 srsf1b srsf1b traf5 traf5 cfp cfp ikbkb ikbkb pou2f1b pou2f1b irak1 irak1 LOC100537384 LOC100537384 A9C4A2_DANRE A9C4A2_DANRE tsc1b tsc1b zgc:153631 zgc:153631 zgc:153759 zgc:153759 srsf3b srsf3b crfb2 crfb2 bcl2a bcl2a eif2ak3 eif2ak3 srsf7a srsf7a hcfc1b hcfc1b pdia8 pdia8 srsf5b srsf5b ifng1 ifng1 irf9 irf9 tyk2 tyk2 tlr18 tlr18 bcl2b bcl2b LOC100004321 LOC100004321 irf3 irf3 tap2t tap2t hcfc2 hcfc2 pik3cb pik3cb il12a il12a ticam1 ticam1 pik3r2 pik3r2 calr3a calr3a il6 il6 ppp1cbl ppp1cbl akt1 akt1 srsf2b srsf2b srsf4 srsf4 tsc2 tsc2 jak2a jak2a tbk1 tbk1 rela rela eif2ak2 eif2ak2 ENSDARP00000134462 ENSDARP00000134462 pdia3 pdia3 calr3b calr3b irak4 irak4 nfkb1 nfkb1 c3a.6 c3a.6 dZ48C11.3-001 dZ48C11.3-001 casp22 casp22 faslg faslg srsf7b srsf7b EIF2AK4 EIF2AK4 tapbp.2 tapbp.2 pik3ca pik3ca zgc:153993 zgc:153993 akt3a akt3a alyref alyref fadd fadd akt2l akt2l il1b il1b ppp1cc ppp1cc pou2f2a pou2f2a traf2b traf2b pou2f3 pou2f3 LOC798191 LOC798191 sting1 sting1 mhc2b mhc2b tap1 tap1 tlr9 tlr9 ENSDARP00000151819 ENSDARP00000151819 zgc:103700 zgc:103700 tnfsf14 tnfsf14 bida bida
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
stat1bSignal transducer and activator of transcription. (725 aa)
ppp1caaSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
cd74aCD74 molecule, major histocompatibility complex, class II invariant chain a. (237 aa)
srsf9Serine and arginine-rich-splicing factor 9. (245 aa)
sykTyrosine-protein kinase. (608 aa)
eif2b1Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (291 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (551 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
hcfc1aHost cell factor C1a. (1802 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa)
M9MM93_DANRESi:ch73-211l2.3. (234 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
ifih1Interferon-induced with helicase C domain 1. (997 aa)
itgb3aIntegrin beta; Belongs to the integrin beta chain family. (785 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
eif2b3Eukaryotic translation initiation factor 2B, subunit 3 gamma. (453 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. (711 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
srsf6bSerine and arginine-rich-splicing factor 6b. (355 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
itgb3bIntegrin beta; Belongs to the integrin beta chain family. (790 aa)
pdia7Protein disulfide-isomerase. (488 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
eif2s1aEukaryotic translation initiation factor 2, subunit 1 alpha, like. (315 aa)
ikbkgInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (586 aa)
itga5Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
tap2aTransporter-associated with antigen-processing, subunit type a. (725 aa)
srpk1aSRSF protein kinase 1a. (634 aa)
ifnphi1Interferon phi 1. (185 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
srsf3aSerine and arginine-rich-splicing factor 3a. (174 aa)
cgasCyclic GMP-AMP synthase. (592 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
pik3r3bPhosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (464 aa)
srpk1bSRSF protein kinase 1b. (658 aa)
srsf5aSerine and arginine-rich-splicing factor 5a. (259 aa)
traf2aTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
mhc2aMajor histocompatibility complex class II integral membrane alpha chain gene. (236 aa)
stat2Signal transducer and activator of transcription. (836 aa)
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)
c3a.3Complement component c3a, duplicate 3. (1651 aa)
c3a.1Complement component c3a, duplicate 1. (1643 aa)
mhc1zbaMHC class I antigen ZBA transcript variant 1; Belongs to the MHC class I family. (398 aa)
tlr2Toll-like receptor 2. (788 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
rhebl1Ras homolog, mTORC1-binding-like 1. (184 aa)
eif2b2Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (355 aa)
eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1. (120 aa)
eif2s1bEukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
b2mBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (116 aa)
badbBCL2-associated agonist of cell death b. (147 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
nxf1Nuclear RNA export factor 1. (642 aa)
fasFas cell surface death receptor. (293 aa)
ikbkeInhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
srsf2aSerine and arginine-rich-splicing factor 2a. (225 aa)
srsf1aSerine/arginine-rich splicing factor 1A; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Belongs to the splicing factor SR family. (257 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
nectin1bNectin cell adhesion molecule 1b. (539 aa)
mavsMitochondrial antiviral-signaling protein. (364 aa)
ppp1cabSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
c5Complement component 5. (1704 aa)
card9Caspase recruitment domain family, member 9. (534 aa)
zmp:0000001127Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (187 aa)
calrCalreticulin. (417 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
srsf6aSerine and arginine-rich-splicing factor 6a. (347 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
tapbp.1TAP-binding protein (tapasin), tandem duplicate 1. (442 aa)
socs3bSuppressor of cytokine-signaling 3b. (210 aa)
eif2b5Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (607 aa)
mhc2dabNovel protein similar to vertebrate major histocompatibility complex class II DAB gene (Mhc2dab). (250 aa)
il12baInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (350 aa)
znf1007Zinc finger protein 1007. (2205 aa)
nectin1aNectin cell adhesion molecule 1a. (475 aa)
ifngr1lInterferon gamma receptor 1-like. (385 aa)
birc2Baculoviral IAP repeat-containing 2. (647 aa)
jak2bTyrosine-protein kinase. (1126 aa)
daxxDeath-domain-associated protein. (716 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
eif2b4Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (540 aa)
rhebRas homolog, mTORC1-binding. (93 aa)
c3a.2Complement component c3a, duplicate 2. (1656 aa)
b2mlBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa)
ppp1cbSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
zgc:153681Zgc:153681. (610 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
badaBCL2-associated agonist of cell death a. (145 aa)
mhc2dcbSi:busm1-228j01.4. (244 aa)
akt3bNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
eif2ak1Eukaryotic translation initiation factor 2-alpha kinase 1. (668 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
srsf1bSerine/arginine-rich splicing factor 1B; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Belongs to the splicing factor SR family. (245 aa)
traf5Tnf receptor-associated factor 5. (305 aa)
cfpComplement factor properdin. (437 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
pou2f1bPOU domain protein. (676 aa)
irak1Interleukin-1 receptor-associated kinase 1. (686 aa)
LOC100537384POU domain protein. (676 aa)
A9C4A2_DANRESi:ch73-237c6.1. (437 aa)
tsc1bTSC complex subunit 1b. (1228 aa)
zgc:153631Zgc:153631. (345 aa)
zgc:153759Zgc:153759. (266 aa)
srsf3bSerine and arginine-rich-splicing factor 3b. (164 aa)
crfb2Cytokine receptor family member b2. (469 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
srsf7aSerine and arginine-rich-splicing factor 7a. (258 aa)
hcfc1bHost cell factor C1b. (1993 aa)
pdia8Protein disulfide-isomerase. (494 aa)
srsf5bSerine and arginine-rich-splicing factor 5b. (285 aa)
ifng1Interferon gamma 1. (179 aa)
irf9Interferon regulatory factor 9. (428 aa)
tyk2Tyrosine-protein kinase. (1165 aa)
tlr18Toll-like receptor 18. (854 aa)
bcl2bBCL2 apoptosis regulator b. (209 aa)
LOC100004321BCL2-associated X, apoptosis regulator a. (197 aa)
irf3Interferon regulatory factor 3. (426 aa)
tap2tTransporter-associated with antigen-processing, subunit type t, teleost-specific. (728 aa)
hcfc2Host cell factor C2. (708 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa)
il12aInterleukin 12a. (196 aa)
ticam1Toll-like receptor adaptor molecule 1. (566 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
calr3aCalreticulin. (418 aa)
il6Interleukin 6 (interferon, beta 2). (231 aa)
ppp1cblSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (231 aa)
akt1Non-specific serine/threonine protein kinase. (247 aa)
srsf2bSerine and arginine-rich-splicing factor 2b. (220 aa)
srsf4Serine and arginine-rich-splicing factor 4. (366 aa)
tsc2TSC complex subunit 2. (1674 aa)
jak2aTyrosine-protein kinase. (1095 aa)
tbk1TANK-binding kinase 1. (727 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
ENSDARP00000134462Si:busm1-194e12.8. (236 aa)
pdia3Protein disulfide-isomerase. (459 aa)
calr3bCalreticulin. (417 aa)
irak4Interleukin-1 receptor-associated kinase 4. (447 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
c3a.6Complement component c3a, duplicate 6. (1642 aa)
dZ48C11.3-001Novel protein similar to MHC class II alpha chain. (236 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
srsf7bSerine and arginine-rich-splicing factor 7b. (178 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1355 aa)
tapbp.2TAP-binding protein (tapasin), tandem duplicate 2. (465 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
zgc:153993Zgc:153993 protein. (204 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
alyrefAly/REF export factor. (291 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
akt2lV-akt murine thymoma viral oncogene homolog 2,-like. (478 aa)
il1bInterleukin-1. (284 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
pou2f2aPOU domain protein. (695 aa)
traf2bTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
pou2f3POU domain protein. (398 aa)
LOC798191Si:dkey-23c22.7. (234 aa)
sting1Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (By similarity). [...] (398 aa)
mhc2bMajor histocompatibility complex class II integral membrane beta chain gene. (252 aa)
tap1Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP). (736 aa)
tlr9Toll-like receptor 9; Belongs to the Toll-like receptor family. (1069 aa)
ENSDARP00000151819Ig-like domain-containing protein. (257 aa)
zgc:103700Zgc:103700. (250 aa)
tnfsf14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (235 aa)
bidaBH3-interacting domain death agonist. (187 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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