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| | hisH | Hypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa) |
| | ANE22716.1 | Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa) |
| | ANE23287.1 | C_GCAxxG_C_C family redox protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa) |
| | ANE23286.1 | 2,5-diketo-D-gluconic acid reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa) |
| | ANE23250.1 | Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa) |
| | ANE23249.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa) |
| | ANE23248.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa) |
| | ANE23558.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (387 aa) |
| | ANE23183.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (452 aa) |
| | ANE23179.1 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa) |
| | ANE23164.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa) |
| | ANE23157.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa) |
| | ANE23153.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1464 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa) |
| | aroK-3 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | serS | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | ANE23040.1 | Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa) |
| | ANE23034.1 | Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa) |
| | ANE23525.1 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1542 aa) |
| | ANE23014.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa) |
| | ANE23012.1 | Serine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa) |
| | ANE23000.1 | Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa) |
| | ANE22983.1 | Glycosyl transferase family 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa) |
| | ANE22964.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa) |
| | ANE22915.1 | Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa) |
| | serC | MFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (423 aa) |
| | ANE22799.1 | Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa) |
| | panD | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | ANE22785.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (450 aa) |
| | carB | Carbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1072 aa) |
| | ANE23370.1 | Zn-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa) |
| | ANE21855.1 | Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa) |
| | ANE21934.1 | Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (532 aa) |
| | ANE21977.1 | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa) |
| | aroD | Hypothetical protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (254 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa) |
| | ANE22019.1 | UDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa) |
| | ANE23400.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa) |
| | ANE22042.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa) |
| | ANE22046.1 | Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | hisZ | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (537 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | dapF | Hypothetical protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (306 aa) |
| | ANE22676.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | ANE22641.1 | Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa) |
| | ANE22631.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (331 aa) |
| | ANE22559.1 | Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa) |
| | ANE22556.1 | HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa) |
| | ANE22550.1 | S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (234 aa) |
| | ANE22546.1 | Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa) |
| | ANE22535.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. (2372 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa) |
| | ANE22520.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa) |
| | ANE22519.1 | Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (605 aa) |
| | ANE22508.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa) |
| | ANE22485.1 | Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (340 aa) |
| | ANE22443.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa) |
| | ANE22442.1 | Alginate O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane-bound acyltransferase family. (473 aa) |
| | ANE22407.1 | 3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (405 aa) |
| | ANE22403.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa) |
| | proC | Hypothetical protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (282 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa) |
| | aroK-2 | Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (182 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | ANE23458.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa) |
| | ANE22359.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa) |
| | ANE23450.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (77 aa) |
| | ANE22314.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (314 aa) |
| | ANE22275.1 | Catalyzes the formation of putrescine from carbamoyl-putrescine during agmatine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (350 aa) |
| | ANE22261.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa) |
| | acpS | ACP synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (168 aa) |
| | ANE22199.1 | Segregation protein B; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa) |
| | ANE22191.1 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | ANE22174.1 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (426 aa) |
| | ANE22157.1 | phosphoribosyl-ATP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PRA-PH family. (139 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (350 aa) |
| | ANE23419.1 | Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa) |
| | accD | acetyl-CoA carboxylase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (778 aa) |
| | ANE22138.1 | 3-hydroxyacyl-ACP dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa) |
| | ANE22137.1 | 3-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (426 aa) |
| | ANE22135.1 | Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa) |
| | acpP | Phosphopantetheine-binding protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (73 aa) |
| | ANE23416.1 | 3-oxoacyl-ACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpB | Phosphoribosylanthranilate isomerase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (202 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (263 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | trpE | Anthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (487 aa) |
| | ANE22115.1 | Isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa) |
| | argH | Argininosuccinate lyase; Catalyzes the formation of arginine from (N-L-arginino)succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa) |
| | argG | Argininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (419 aa) |
| | argR | ArgR family transcriptional regulator; Regulates arginine biosynthesis genes. (142 aa) |
| | ANE22105.1 | Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (315 aa) |
| | argJ | Arginine biosynthesis protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (420 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (353 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa) |
