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| | AGB29957.1 | PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase; Belongs to the aspartokinase family. (392 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisA | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (250 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa) |
| | AGB30038.1 | TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (230 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (419 aa) |
| | AGB30042.1 | OAH/OAS sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. (459 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (429 aa) |
| | AGB30135.1 | PFAM: Prephenate dehydratase; ACT domain. (272 aa) |
| | hisE | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. (94 aa) |
| | AGB30279.1 | Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (370 aa) |
| | AGB30292.1 | Hypothetical protein; PFAM: Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); TIGRFAM: arginine decarboxylase, pyruvoyl-dependent. (159 aa) |
| | AGB30394.1 | Agmatinase; PFAM: Arginase family; TIGRFAM: agmatinase; Belongs to the arginase family. (282 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (383 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (295 aa) |
| | AGB30588.1 | Homoserine dehydrogenase; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Homoserine dehydrogenase. (315 aa) |
| | AGB30658.1 | Threonine dehydratase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. (403 aa) |
| | AGB30682.1 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (377 aa) |
| | AGB30701.1 | Threonine dehydratase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. (419 aa) |
| | AGB30858.1 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (397 aa) |
| | AGB30887.1 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. (326 aa) |
| | AGB30889.1 | PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit. (211 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (348 aa) |
| | AGB30893.1 | PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (219 aa) |
| | AGB30894.1 | Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. (604 aa) |
| | AGB30896.1 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. (445 aa) |
| | ilvE | Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (220 aa) |
| | speE | Putative spermidine synthase with an N-terminal membrane domain; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (560 aa) |
| | AGB31060.1 | PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (215 aa) |
| | trpE | Anthranilate synthase component I, archaeal clade; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate a [...] (560 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (218 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (355 aa) |
| | aroK | PFAM: GHMP kinases N terminal domain; TIGRFAM: shikimate kinase. (290 aa) |
| | AGB31089.1 | PFAM: Chorismate mutase type II; TIGRFAM: chorismate mutase, archaeal type. (108 aa) |
| | AGB31133.1 | PFAM: Malic enzyme, NAD binding domain; Phosphate acetyl/butaryl transferase; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. (751 aa) |
| | AGB31301.1 | PFAM: Aminotransferase class I and II. (366 aa) |
| | AGB31318.1 | Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. (388 aa) |
| | AGB31326.1 | Methionine synthase II (cobalamin-independent); PFAM: Cobalamin-independent synthase, N-terminal domain. (334 aa) |
| | AGB31327.1 | Methionine synthase II (cobalamin-independent); PFAM: Cobalamin-independent synthase, Catalytic domain. (357 aa) |
| | AGB31406.1 | PFAM: Arginase family; TIGRFAM: arginase; Belongs to the arginase family. (306 aa) |
| | AGB31543.1 | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase. (307 aa) |
| | AGB31647.1 | PFAM: Arginase family; TIGRFAM: arginase; Belongs to the arginase family. (318 aa) |
| | AGB31651.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (548 aa) |
| | AGB31866.1 | Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; manually curated; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa) |
| | ilvD | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (575 aa) |
| | AGB31919.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (562 aa) |
| | AGB31923.1 | FAD/FMN-dependent dehydrogenase; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD. (473 aa) |
| | AGB31930.1 | PFAM: Aminotransferase class I and II. (373 aa) |
| | hisC | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. (381 aa) |
| | AGB32066.1 | PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms). (344 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa) |
| | cysS | PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase. (499 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | AGB32298.1 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (326 aa) |
| | katG | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (713 aa) |
| | AGB32535.1 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (326 aa) |
| | AGB32679.1 | Putative amidohydrolase; PFAM: Carbon-nitrogen hydrolase. (284 aa) |
| | AGB32713.1 | PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase, HisJ family. (261 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa) |
| | AGB32804.1 | PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic. (390 aa) |
| | AGB32812.1 | PFAM: Prephenate dehydrogenase. (256 aa) |
| | AGB32843.1 | PFAM: Aminotransferase class I and II. (381 aa) |
| | AGB32878.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (778 aa) |
| | AGB32908.1 | OAH/OAS sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. (430 aa) |
| | AGB32976.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (526 aa) |
| | AGB33006.1 | Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (389 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (276 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (458 aa) |
| | dapD | Tetrahydrodipicolinate N-succinyltransferase; PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (278 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (255 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (307 aa) |
| | AGB33031.1 | Amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (442 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | AGB33048.1 | Aminodeoxychorismate synthase, component I, clade 2; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, clade 2. (534 aa) |
| | AGB33049.1 | PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (236 aa) |
| | AGB33052.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; PFAM: Aminotransferase class IV. (290 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (280 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (421 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (312 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (226 aa) |
| | AGB33106.1 | PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa) |
| | AGB33151.1 | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases. (314 aa) |
| | AGB33175.1 | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; manually curated. (193 aa) |
| | AGB33306.1 | Anthranilate phosphoribosyltransferase; PFAM: Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: anthranilate phosphoribosyltransferase. (355 aa) |
| | AGB33441.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (425 aa) |
| | AGB33445.1 | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (309 aa) |
| | lysK-2 | N-acetyl-ornithine/N-acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (356 aa) |
| | lysJ | Ornithine/acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (382 aa) |
| | lysZ | Acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (290 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase, common form; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (358 aa) |
| | AGB33450.1 | PFAM: RimK-like ATP-grasp domain; TIGRFAM: Lysine biosynthesis enzyme LysX; alpha-L-glutamate ligases, RimK family. (292 aa) |
| | AGB33451.1 | TIGRFAM: lysine biosynthesis protein LysW. (54 aa) |
| | argH | PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (506 aa) |
| | argG | PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | AGB33600.1 | Serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase. (171 aa) |
