STRINGSTRING
hjc hjc rnp1 rnp1 AFZ71605.1 AFZ71605.1 nth nth AFZ71763.1 AFZ71763.1 mre11 mre11 rnp4 rnp4 fen fen AFZ72010.1 AFZ72010.1 AFZ72208.1 AFZ72208.1 AFZ72243.1 AFZ72243.1 rnhB rnhB nucS nucS AFZ72366.1 AFZ72366.1 fau-1 fau-1 endA endA AFZ72574.1 AFZ72574.1 polC polC AFZ72666.1 AFZ72666.1 AFZ72679.1 AFZ72679.1 uvrB uvrB polB polB AFZ72829.1 AFZ72829.1 AFZ72901.1 AFZ72901.1 uvrC uvrC rnz rnz AFZ73003.1 AFZ73003.1 AFZ73075.1 AFZ73075.1 AFZ73102.1 AFZ73102.1 AFZ73206.1 AFZ73206.1 nfi nfi pelA pelA AFZ73245.1 AFZ73245.1 AFZ73252.1 AFZ73252.1 uvrA uvrA AFZ73490.1 AFZ73490.1 nfo nfo nucS-2 nucS-2 AFZ73692.1 AFZ73692.1 AFZ73700.1 AFZ73700.1 rnj rnj rpl7ae rpl7ae AFZ73742.1 AFZ73742.1 AFZ73773.1 AFZ73773.1 AFZ73774.1 AFZ73774.1 AFZ73776.1 AFZ73776.1 AFZ73795.1 AFZ73795.1 AFZ73800.1 AFZ73800.1 AFZ73802.1 AFZ73802.1 AFZ73879.1 AFZ73879.1 AFZ74159.1 AFZ74159.1 cas4 cas4 cas1 cas1 cas2 cas2 AFZ74724.1 AFZ74724.1 rnp3 rnp3 rnp2 rnp2 AFZ74770.1 AFZ74770.1 AFZ74777.1 AFZ74777.1 AFZ74819.1 AFZ74819.1 AFZ74835.1 AFZ74835.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hjcHolliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (172 aa)
rnp1RNase P/RNase MRP subunit p29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (150 aa)
AFZ71605.1PFAM: HNH endonuclease. (241 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
AFZ71763.1Hypothetical protein. (394 aa)
mre11DNA repair exonuclease; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. (441 aa)
rnp4RNase P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (102 aa)
fenFlap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (325 aa)
AFZ72010.1Lon-related putative ATP-dependent protease; PFAM: Magnesium chelatase, subunit ChlI; Sigma-54 interaction domain; Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: lon-related putative ATP-dependent protease; Belongs to the peptidase S16 family. (731 aa)
AFZ72208.1PFAM: Protein of unknown function DUF88. (165 aa)
AFZ72243.1Putative nucleic acid-binding protein with PIN domain and Zn ribbon. (152 aa)
rnhBRibonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (221 aa)
nucSPutative nuclease of the RecB family; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (263 aa)
AFZ72366.1Hypothetical protein. (262 aa)
fau-1Protein of unknown function (DUF402); Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. (478 aa)
endAtRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (353 aa)
AFZ72574.1Hypothetical protein. (260 aa)
polCDNA polymerase type II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1211 aa)
AFZ72666.1Single-stranded DNA-specific exonuclease; PFAM: DHHA1 domain; DHH family. (494 aa)
AFZ72679.1Putative metal-dependent phosphoesterase, PHP family; PFAM: PHP domain. (272 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (685 aa)
polBArchaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (518 aa)
AFZ72829.1Putative nucleic acid-binding protein, contains PIN domain; PFAM: PIN domain. (137 aa)
AFZ72901.1PFAM: Helicase conserved C-terminal domain; ERCC4 domain; DEAD/DEAH box helicase. (803 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (585 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (308 aa)
AFZ73003.1Ribonuclease HI; PFAM: RNase H. (244 aa)
AFZ73075.1Hypothetical protein. (585 aa)
AFZ73102.1Putative exonuclease of the beta-lactamase fold involved in RNA processing; PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain. (412 aa)
AFZ73206.1Hypothetical protein; PFAM: Uncharacterised ACR, COG1259. (155 aa)
nfiDeoxyinosine 3'endonuclease (endonuclease V); DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (257 aa)
pelAPutative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (355 aa)
AFZ73245.1Metal-dependent hydrolase, beta-lactamase superfamily III. (244 aa)
AFZ73252.1DNA/RNA helicase, superfamily I; PFAM: DNA replication factor Dna2; UvrD/REP helicase. (891 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (987 aa)
AFZ73490.1PilT domain protein; PFAM: Fcf1. (132 aa)
nfoApurinic endonuclease APN1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (290 aa)
nucS-2Putative nuclease of the RecB family; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (251 aa)
AFZ73692.1Putative endoIII-related endonuclease; PFAM: HhH-GPD superfamily base excision DNA repair protein; Iron-sulfur binding domain of endonuclease III. (270 aa)
AFZ73700.1Ribonuclease HI; PFAM: RNase H. (196 aa)
rnjPutative hydrolase of the metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (450 aa)
rpl7ae50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (120 aa)
AFZ73742.1Hypothetical protein. (169 aa)
AFZ73773.1PFAM: Restriction endonuclease. (164 aa)
AFZ73774.1DNA repair exonuclease; PFAM: Calcineurin-like phosphoesterase. (504 aa)
AFZ73776.1NurA domain-containing protein; PFAM: NurA domain. (421 aa)
AFZ73795.1PFAM: HNH endonuclease. (354 aa)
AFZ73800.1PFAM: HNH endonuclease. (413 aa)
AFZ73802.1Hypothetical protein; PFAM: Type I restriction enzyme R protein N terminus (HSDR_N). (387 aa)
AFZ73879.1PFAM: RNB domain; TIGRFAM: VacB and RNase II family 3'-5' exoribonucleases. (436 aa)
AFZ74159.1PFAM: Protein of unknown function DUF88; TIGRFAM: TIGR00288 family protein. (154 aa)
cas4CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (198 aa)
cas1CRISPR-associated endonuclease Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (330 aa)
cas2CRISPR-associated endoribonuclease Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (86 aa)
AFZ74724.1Putative metal-dependent phosphoesterase, PHP family; PFAM: PHP domain. (228 aa)
rnp3RNase P/RNase MRP subunit p30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (234 aa)
rnp2RNase P/RNase MRP subunit POP5; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (164 aa)
AFZ74770.1ATP-dependent exonuclase V beta subunit, helicase and exonuclease domain-containing; PFAM: UvrD/REP helicase. (1223 aa)
AFZ74777.1Hypothetical protein; PFAM: Domain of unknown function DUF123. (137 aa)
AFZ74819.1Putative metal-dependent hydrolase (urease superfamily); PFAM: TatD related DNase. (287 aa)
AFZ74835.1Ribonuclease HI. (216 aa)
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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