(45 nodes) Mismatch repair network (Clonorchis sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKRIP1	PRKR-interacting protein 1. (170 aa)
	TREX1	Three-prime repair exonuclease 1. (203 aa)
	CLF_102744	DNA polymerase. (1128 aa)
	REXO4	RNA exonuclease 4. (395 aa)
	MLH3	DNA mismatch repair protein MLH3. (229 aa)
	MSH5	MutS-like protein 5. (436 aa)
	rpa1-2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (560 aa)
	MSH4	MutS-like protein 4. (1093 aa)
	CSKR_12572s	Uncharacterized protein. (470 aa)
	CSKR_13104s	DDE_Tnp_IS1595 domain-containing protein. (251 aa)
	RAD17	Cell cycle checkpoint protein RAD17. (661 aa)
	RFC5	Replication factor C subunit 5. (352 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (934 aa)
	CSKR_6571s	DDE_Tnp_IS1595 domain-containing protein. (223 aa)
	CSKR_11626s	DDE_Tnp_IS1595 domain-containing protein. (198 aa)
	CSKR_4233s	DDE_Tnp_IS1595 domain-containing protein. (647 aa)
	Ppil3	Peptidyl-prolyl cis-trans isomerase-like 3. (73 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (476 aa)
	Rfc2	Replication factor C subunit 2. (384 aa)
	ISG20L2	Interferon-stimulated 20 kDa exonuclease-like 2. (1500 aa)
	Rfc4	Replication factor C subunit 4. (405 aa)
	exo1	Exonuclease 1. (1444 aa)
	CSKR_13120s	DDE_Tnp_IS1595 domain-containing protein. (208 aa)
	RPA2	Replication protein A 32 kDa subunit. (263 aa)
	CSKR_13641s	DDE_Tnp_IS1595 domain-containing protein. (276 aa)
	lig1	DNA ligase. (631 aa)
	CSKR_13379s	Uncharacterized protein. (134 aa)
	Msh6	DNA mismatch repair protein Msh6. (726 aa)
	CSKR_9198s	Uncharacterized protein. (217 aa)
	RFC3	Replication factor C subunit 3. (357 aa)
	Mlh1	DNA mismatch repair protein Mlh1. (943 aa)
	CSKR_543s	Uncharacterized protein. (310 aa)
	CSKR_7251s	Uncharacterized protein. (384 aa)
	CSKR_6168s	Uncharacterized protein. (194 aa)
	MSH2	DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). (1115 aa)
	CSKR_9522s	Uncharacterized protein. (503 aa)
	Rfc1	Replication factor C subunit 1. (767 aa)
	Ccdc94	Coiled-coil domain-containing protein 94. (904 aa)
	CSKR_3979s	Uncharacterized protein. (123 aa)
	obfc1	CST complex subunit STN1. (602 aa)
	CSKR_10037s	DDE_Tnp_IS1595 domain-containing protein. (128 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1075 aa)
	PMS2	Mismatch repair endonuclease PMS2. (561 aa)
	CSKR_740s	Uncharacterized protein. (109 aa)
	SASS6	Spindle assembly abnormal protein 6-like protein. (439 aa)

Your Current Organism:

Clonorchis sinensis

NCBI taxonomy Id: 79923
Other names: C. sinensis, oriental liver fluke

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CLF_102744	A0A3R7CSP3	G7YN68	ATPase family AAA domain-containing protein 5.	DNA polymerase.	0.797
ATAD5	CSKR_7251s	A0A3R7CSP3	A0A3R7FRX1	ATPase family AAA domain-containing protein 5.	Uncharacterized protein.	0.730
ATAD5	CSKR_740s	A0A3R7CSP3	A0A3R7C9X6	ATPase family AAA domain-containing protein 5.	Uncharacterized protein.	0.756
ATAD5	MEIOB	A0A3R7CSP3	A0A419PL44	ATPase family AAA domain-containing protein 5.	Meiosis-specific with OB domain-containing protein.	0.788
ATAD5	MSH2	A0A3R7CSP3	A0A3R7F047	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR).	0.434
ATAD5	Msh6	A0A3R7CSP3	A0A3R7GMX1	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein Msh6.	0.462
ATAD5	RAD17	A0A3R7CSP3	A0A419Q9T8	ATPase family AAA domain-containing protein 5.	Cell cycle checkpoint protein RAD17.	0.950
ATAD5	RFC3	A0A3R7CSP3	A0A3R7FZX9	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 3.	0.992
ATAD5	RFC5	A0A3R7CSP3	A0A419Q913	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 5.	0.990
ATAD5	RPA2	A0A3R7CSP3	A0A3R7H3Z5	ATPase family AAA domain-containing protein 5.	Replication protein A 32 kDa subunit.	0.660
ATAD5	Rfc1	A0A3R7CSP3	A0A3R7ESD7	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 1.	0.636
ATAD5	Rfc2	A0A3R7CSP3	A0A419PJF7	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 2.	0.986
ATAD5	Rfc4	A0A3R7CSP3	A0A419PH85	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 4.	0.991
ATAD5	SASS6	A0A3R7CSP3	A0A3R7C605	ATPase family AAA domain-containing protein 5.	Spindle assembly abnormal protein 6-like protein.	0.674
ATAD5	exo1	A0A3R7CSP3	A0A419PFQ3	ATPase family AAA domain-containing protein 5.	Exonuclease 1.	0.953
ATAD5	lig1	A0A3R7CSP3	A0A3R7GUR9	ATPase family AAA domain-containing protein 5.	DNA ligase.	0.756
ATAD5	obfc1	A0A3R7CSP3	A0A3R7D4C1	ATPase family AAA domain-containing protein 5.	CST complex subunit STN1.	0.641
ATAD5	pcna	A0A3R7CSP3	A0A419Q8E3	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
ATAD5	rpa1-2	A0A3R7CSP3	A0A419QCA6	ATPase family AAA domain-containing protein 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.788
CLF_102744	ATAD5	G7YN68	A0A3R7CSP3	DNA polymerase.	ATPase family AAA domain-containing protein 5.	0.797