(15 nodes) CORVET complex, and Clathrin, heavy chain/VPS, 7-fold repeat network (Astyanax mexicanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	vps8	VPS8 subunit of CORVET complex. (1409 aa)
	vps41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
	Vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (946 aa)
	W5KC71_ASTMX	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (801 aa)
	ccz1	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. (480 aa)
	tgfbrap1	Transforming growth factor, beta receptor associated protein 1. (927 aa)
	vps33a	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (600 aa)
	LOC103034209	RAB5B, member RAS oncogene family. (275 aa)
	vps18	VPS18 core subunit of CORVET and HOPS complexes. (978 aa)
	W5LIS1_ASTMX	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (456 aa)
	rbsn	Rabenosyn, RAB effector. (783 aa)
	W5LNR1_ASTMX	Si:ch211-266g18.9. (822 aa)
	vps45	Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (564 aa)
	vps33b	VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	vps39	VPS39 subunit of HOPS complex. (875 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103034209	Vps11	ENSAMXP00000015419	ENSAMXP00000004514	RAB5B, member RAS oncogene family.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.674
LOC103034209	W5KC71_ASTMX	ENSAMXP00000015419	ENSAMXP00000005182	RAB5B, member RAS oncogene family.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.689
LOC103034209	W5LNR1_ASTMX	ENSAMXP00000015419	ENSAMXP00000021473	RAB5B, member RAS oncogene family.	Si:ch211-266g18.9.	0.596
LOC103034209	ccz1	ENSAMXP00000015419	ENSAMXP00000008128	RAB5B, member RAS oncogene family.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.470
LOC103034209	rbsn	ENSAMXP00000015419	ENSAMXP00000020468	RAB5B, member RAS oncogene family.	Rabenosyn, RAB effector.	0.873
LOC103034209	tgfbrap1	ENSAMXP00000015419	ENSAMXP00000009924	RAB5B, member RAS oncogene family.	Transforming growth factor, beta receptor associated protein 1.	0.596
LOC103034209	vps18	ENSAMXP00000015419	ENSAMXP00000017763	RAB5B, member RAS oncogene family.	VPS18 core subunit of CORVET and HOPS complexes.	0.694
LOC103034209	vps33a	ENSAMXP00000015419	ENSAMXP00000014081	RAB5B, member RAS oncogene family.	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.	0.596
LOC103034209	vps33b	ENSAMXP00000015419	ENSAMXP00000041269	RAB5B, member RAS oncogene family.	VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family.	0.596
LOC103034209	vps39	ENSAMXP00000015419	ENSAMXP00000048859	RAB5B, member RAS oncogene family.	VPS39 subunit of HOPS complex.	0.700
LOC103034209	vps41	ENSAMXP00000015419	ENSAMXP00000002952	RAB5B, member RAS oncogene family.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.632
LOC103034209	vps45	ENSAMXP00000015419	ENSAMXP00000030653	RAB5B, member RAS oncogene family.	Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.	0.772
LOC103034209	vps8	ENSAMXP00000015419	ENSAMXP00000000649	RAB5B, member RAS oncogene family.	VPS8 subunit of CORVET complex.	0.631
Vps11	LOC103034209	ENSAMXP00000004514	ENSAMXP00000015419	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	RAB5B, member RAS oncogene family.	0.674
Vps11	W5KC71_ASTMX	ENSAMXP00000004514	ENSAMXP00000005182	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.997
Vps11	W5LIS1_ASTMX	ENSAMXP00000004514	ENSAMXP00000019733	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog.	0.623
Vps11	W5LNR1_ASTMX	ENSAMXP00000004514	ENSAMXP00000021473	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Si:ch211-266g18.9.	0.963
Vps11	ccz1	ENSAMXP00000004514	ENSAMXP00000008128	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.973
Vps11	rbsn	ENSAMXP00000004514	ENSAMXP00000020468	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Rabenosyn, RAB effector.	0.737
Vps11	tgfbrap1	ENSAMXP00000004514	ENSAMXP00000009924	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Transforming growth factor, beta receptor associated protein 1.	0.978