122 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103041890	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa)
	LOC103036701	Endothelial PAS domain protein 1a. (816 aa)
	W5K0L4_ASTMX	MADS-box domain-containing protein. (479 aa)
	W5K0V1_ASTMX	Si:ch73-380n15.2. (530 aa)
	BCL2	BCL2 apoptosis regulator. (201 aa)
	LOC103026553	Von Hippel-Lindau tumor suppressor. (170 aa)
	fndc1	Fibronectin type III domain containing 1. (1646 aa)
	Loxl4	Lysyl oxidase-like 4. (826 aa)
	egln3	Egl-9 family hypoxia-inducible factor 3. (239 aa)
	tm9sf4	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (650 aa)
	Cct4	T-complex protein 1 subunit delta. (582 aa)
	Sirt1	Deacetylase sirtuin-type domain-containing protein. (802 aa)
	ajuba	Ajuba LIM protein. (691 aa)
	LOC103033735	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family. (420 aa)
	LOC103041996	ADAM metallopeptidase domain 17b. (841 aa)
	cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (569 aa)
	W5KCM2_ASTMX	Si:cabz01100188.1. (855 aa)
	W5KDH4_ASTMX	Prostaglandin-endoperoxide synthase 2a. (580 aa)
	LOC103040838	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	W5KGH6_ASTMX	Neurofibromin 1b. (2733 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (637 aa)
	cryab	Crystallin, alpha B, b; Belongs to the small heat shock protein (HSP20) family. (172 aa)
	LOC103044365	E1A binding protein p300 a. (2671 aa)
	LOC103027586	Hypoxia inducible factor 1 subunit alpha, like. (636 aa)
	tbl2	Transducin (beta)-like 2. (439 aa)
	LOC103026358	Peroxisome proliferator-activated receptor delta a. (490 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (412 aa)
	W5KRB2_ASTMX	Si:ch211-39a7.1. (430 aa)
	Hsp90b1	Heat shock protein 90, beta (grp94), member 1. (793 aa)
	LOC103034574	Prostaglandin-endoperoxide synthase 2b. (608 aa)
	W5KT32_ASTMX	Neurofibromin 1a. (2744 aa)
	ak4	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (233 aa)
	LOC103038005	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region b. (494 aa)
	LOC103029567	Recombination signal binding protein for immunoglobulin kappa J region a. (502 aa)
	Mpl	MPL proto-oncogene, thrombopoietin receptor. (692 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (158 aa)
	plekhn1	Pleckstrin homology domain containing, family N member 1. (703 aa)
	ep300	E1A binding protein p300 b. (2652 aa)
	LOC103047839	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (460 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2518 aa)
	W5L5Z2_ASTMX	Family with sequence similarity 162 member A. (216 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (455 aa)
	W5LD66_ASTMX	Mothers against decapentaplegic homolog. (573 aa)
	W5LD95_ASTMX	ADAM metallopeptidase domain 17a. (675 aa)
	LOC103022359	Mothers against decapentaplegic homolog. (587 aa)
	hmox2	Heme oxygenase 2b. (323 aa)
	LOC103029394	Mothers against decapentaplegic homolog. (544 aa)
	W5LL98_ASTMX	Aryl-hydrocarbon receptor nuclear translocator 2. (630 aa)
	W5LMT7_ASTMX	Lysyl oxidase-like 2a. (720 aa)
	Wtip	WT1 interacting protein. (632 aa)
	LOC107197269	Heme oxygenase 2a. (304 aa)
	LONP1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (983 aa)
	ENSAMXP00000028069	Egl-9 family hypoxia-inducible factor 1a. (126 aa)
	ENSAMXP00000028486	Mothers against decapentaplegic homolog. (493 aa)
	bnip3	BCL2 interacting protein 3. (198 aa)
	SRF	Serum response factor. (527 aa)
	LOC103032659	BCL2 associated agonist of cell death b. (179 aa)
	scap	SREBF chaperone. (1255 aa)
	LOC103030863	Uncharacterized protein. (437 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (387 aa)
	ddit4	DNA-damage-inducible transcript 4. (216 aa)
	LOC103045388	Cytoplasmic polyadenylation element binding protein 1a. (558 aa)
	LOC103024026	Uncharacterized protein. (189 aa)
	LOC103047177	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa)
	LOC107197257	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	vegfd	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (318 aa)
	ENSAMXP00000033131	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	ENSAMXP00000033533	Endothelial PAS domain protein 1b. (830 aa)
	LOC103037932	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1347 aa)
	Vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (339 aa)
	LOC103035866	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1514 aa)
	LOC107197829	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (166 aa)
	ndnf	Neuron-derived neurotrophic factor. (577 aa)
	LOC103047661	Egl-9 family hypoxia-inducible factor 2. (538 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (721 aa)
	nkx3-1	NK3 homeobox 1. (202 aa)
	Apln	Uncharacterized protein. (331 aa)
	ENSAMXP00000037899	MADS-box domain-containing protein. (356 aa)
	MYOCD	Myocardin. (999 aa)
	ENSAMXP00000038669	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (568 aa)
	fundc1	FUN14 domain containing 1. (152 aa)
	LOC103023460	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	LOC103024632	BCL2 interacting protein 3 like a. (237 aa)
	LOC103047410	Aryl hydrocarbon receptor nuclear translocator. (778 aa)
	stox1	Storkhead box 1. (986 aa)
	LOC103040845	Nuclear factor, erythroid 2-like 2b. (569 aa)
	rgcc	Regulator of cell cycle. (128 aa)
	ENSAMXP00000040109	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (144 aa)
	LOC103035447	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (265 aa)
	LOC103029880	Von Hippel-Lindau tumor suppressor like. (181 aa)
	pink1	PTEN induced kinase 1. (571 aa)
	LOC103031258	Lysyl oxidase-like 2b. (770 aa)
	LOC103047163	BCL2 associated agonist of cell death a. (213 aa)
	LOC103039548	BCL2 apoptosis regulator. (218 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (538 aa)
	ENSAMXP00000044990	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (259 aa)
	LOC103030483	Cholinergic receptor, nicotinic, alpha 7 (neuronal). (506 aa)
	ENSAMXP00000046430	Rho-GAP domain-containing protein. (61 aa)
	txn2	Thioredoxin 2. (166 aa)
	usf1	Upstream transcription factor 1. (309 aa)
	Rest	RE1-silencing transcription factor. (1235 aa)
	mecp2	Methyl CpG binding protein 2. (612 aa)
	LOC103028894	Storkhead box 2b. (975 aa)
	ENSAMXP00000047335	Uncharacterized protein. (141 aa)
	ENSAMXP00000047894	Endothelin 1. (162 aa)
	hif1an	Hypoxia inducible factor 1 subunit alpha inhibitor. (355 aa)
	Hyou1	Hypoxia up-regulated 1. (1030 aa)
	FUNDC1	FUN14 domain containing 1. (156 aa)
	LOC103033738	Uncharacterized protein. (490 aa)
	ENSAMXP00000051375	2-aminoethanethiol (cysteamine) dioxygenase b. (273 aa)
	ENSAMXP00000051555	Plasminogen activator, tissue. (601 aa)
	LOC103042476	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	alkbh5	AlkB homolog 5, RNA demethylase. (362 aa)
	ENSAMXP00000051961	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (419 aa)
	LOC103029179	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
	cpeb2	Cytoplasmic polyadenylation element binding protein 2. (782 aa)
	ENSAMXP00000053345	MH1 domain-containing protein. (187 aa)
	LIMD1	LIM domains containing 1. (639 aa)
	pam	Peptidylglycine alpha-amidating monooxygenase. (1006 aa)
	LOC103033873	Hypoxia inducible factor 1 subunit alpha b. (785 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	LOC103024632	ENSAMXP00000001863	ENSAMXP00000038841	BCL2 apoptosis regulator.	BCL2 interacting protein 3 like a.	0.497
BCL2	LOC103032659	ENSAMXP00000001863	ENSAMXP00000029182	BCL2 apoptosis regulator.	BCL2 associated agonist of cell death b.	0.928
BCL2	LOC103047163	ENSAMXP00000001863	ENSAMXP00000043292	BCL2 apoptosis regulator.	BCL2 associated agonist of cell death a.	0.869
BCL2	bnip3	ENSAMXP00000001863	ENSAMXP00000028640	BCL2 apoptosis regulator.	BCL2 interacting protein 3.	0.755
Cct4	Hsp90b1	ENSAMXP00000003135	ENSAMXP00000010377	T-complex protein 1 subunit delta.	Heat shock protein 90, beta (grp94), member 1.	0.581
Cct4	Hyou1	ENSAMXP00000003135	ENSAMXP00000049057	T-complex protein 1 subunit delta.	Hypoxia up-regulated 1.	0.432
Cct4	LONP1	ENSAMXP00000003135	ENSAMXP00000022212	T-complex protein 1 subunit delta.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.596
Cct4	SRF	ENSAMXP00000003135	ENSAMXP00000028964	T-complex protein 1 subunit delta.	Serum response factor.	0.469
ENSAMXP00000028069	ENSAMXP00000033533	ENSAMXP00000028069	ENSAMXP00000033533	Egl-9 family hypoxia-inducible factor 1a.	Endothelial PAS domain protein 1b.	0.794
ENSAMXP00000028069	LIMD1	ENSAMXP00000028069	ENSAMXP00000053555	Egl-9 family hypoxia-inducible factor 1a.	LIM domains containing 1.	0.551
ENSAMXP00000028069	LOC103026553	ENSAMXP00000028069	ENSAMXP00000002224	Egl-9 family hypoxia-inducible factor 1a.	Von Hippel-Lindau tumor suppressor.	0.695
ENSAMXP00000028069	LOC103027586	ENSAMXP00000028069	ENSAMXP00000008817	Egl-9 family hypoxia-inducible factor 1a.	Hypoxia inducible factor 1 subunit alpha, like.	0.794
ENSAMXP00000028069	LOC103029880	ENSAMXP00000028069	ENSAMXP00000040511	Egl-9 family hypoxia-inducible factor 1a.	Von Hippel-Lindau tumor suppressor like.	0.718
ENSAMXP00000028069	LOC103033873	ENSAMXP00000028069	ENSAMXP00000054066	Egl-9 family hypoxia-inducible factor 1a.	Hypoxia inducible factor 1 subunit alpha b.	0.794
ENSAMXP00000028069	LOC103036701	ENSAMXP00000028069	ENSAMXP00000000032	Egl-9 family hypoxia-inducible factor 1a.	Endothelial PAS domain protein 1a.	0.794
ENSAMXP00000028069	Wtip	ENSAMXP00000028069	ENSAMXP00000021654	Egl-9 family hypoxia-inducible factor 1a.	WT1 interacting protein.	0.551
ENSAMXP00000028069	ajuba	ENSAMXP00000028069	ENSAMXP00000003957	Egl-9 family hypoxia-inducible factor 1a.	Ajuba LIM protein.	0.429
ENSAMXP00000028069	hif1a	ENSAMXP00000028069	ENSAMXP00000036632	Egl-9 family hypoxia-inducible factor 1a.	Hypoxia inducible factor 1 subunit alpha a.	0.794
ENSAMXP00000028486	LOC103042476	ENSAMXP00000028486	ENSAMXP00000051642	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.427
ENSAMXP00000028486	LOC103044365	ENSAMXP00000028486	ENSAMXP00000007693	Mothers against decapentaplegic homolog.	E1A binding protein p300 a.	0.567