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LOC103039568 LOC103039568 lrp6 lrp6 sema3a sema3a LOC103021856 LOC103021856 W5K0L4_ASTMX W5K0L4_ASTMX LOC103033117 LOC103033117 W5K1E9_ASTMX W5K1E9_ASTMX Nfatc4 Nfatc4 BCL2 BCL2 tgfb1 tgfb1 W5K5H8_ASTMX W5K5H8_ASTMX LOC103026658 LOC103026658 W5KA92_ASTMX W5KA92_ASTMX prdm1 prdm1 Lrp5 Lrp5 W5KF46_ASTMX W5KF46_ASTMX ctsz ctsz W5KHF9_ASTMX W5KHF9_ASTMX W5KIU0_ASTMX W5KIU0_ASTMX Gbx2 Gbx2 LOC103024607 LOC103024607 LOC103023715 LOC103023715 W5KU03_ASTMX W5KU03_ASTMX W5KUR6_ASTMX W5KUR6_ASTMX ar ar LOC103024223 LOC103024223 W5L1C8_ASTMX W5L1C8_ASTMX Gdf7 Gdf7 Dag1 Dag1 socs2 socs2 plxna1 plxna1 sars1 sars1 W5LD66_ASTMX W5LD66_ASTMX W5LE75_ASTMX W5LE75_ASTMX tmem59l tmem59l LOC103022359 LOC103022359 LOC103029394 LOC103029394 tgfbr2 tgfbr2 LOC103047157 LOC103047157 nrarp nrarp LOC103024806 LOC103024806 LOC103036536 LOC103036536 ENSAMXP00000028486 ENSAMXP00000028486 ENSAMXP00000028909 ENSAMXP00000028909 SRF SRF med1 med1 setd2 setd2 sfrp5 sfrp5 ENSAMXP00000030591 ENSAMXP00000030591 greb1 greb1 hs6st2 hs6st2 LOC107197257 LOC107197257 ENSAMXP00000032821 ENSAMXP00000032821 ENSAMXP00000033131 ENSAMXP00000033131 LOC103027348 LOC103027348 ctsh ctsh NRARP NRARP LOC103028976 LOC103028976 fem1b fem1b LOC103024868 LOC103024868 nkx3-1 nkx3-1 ENSAMXP00000037031 ENSAMXP00000037031 sema3c sema3c LOC103029324 LOC103029324 ENSAMXP00000037899 ENSAMXP00000037899 Plxna4 Plxna4 hhip hhip LOC103045523 LOC103045523 fgf7 fgf7 LOC103035447 LOC103035447 ENSAMXP00000040763 ENSAMXP00000040763 ENSAMXP00000041303 ENSAMXP00000041303 LOC103042847 LOC103042847 ENSAMXP00000041681 ENSAMXP00000041681 LOC103047885 LOC103047885 ENSAMXP00000042872 ENSAMXP00000042872 gdnf gdnf timeless timeless LOC103038135 LOC103038135 LOC103042559 LOC103042559 LOC103039548 LOC103039548 lef1 lef1 TMED2 TMED2 wnt6 wnt6 bmp4 bmp4 spry1 spry1 ENSAMXP00000047894 ENSAMXP00000047894 wt1 wt1 LOC111194998 LOC111194998 ctnnbip1 ctnnbip1 rspo2 rspo2 LOC103045744 LOC103045744 il10 il10 ENSAMXP00000049950 ENSAMXP00000049950 ENSAMXP00000050201 ENSAMXP00000050201 spint1 spint1 BTBD7 BTBD7 LOC103037384 LOC103037384 tgfb2 tgfb2 Dlg5 Dlg5 ilk ilk ENSAMXP00000054825 ENSAMXP00000054825 ENSAMXP00000053345 ENSAMXP00000053345 LOC103031663 LOC103031663
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103039568SRY-box transcription factor 9b. (480 aa)
lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1618 aa)
sema3aSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (780 aa)
LOC103021856Bone morphogenetic protein 2a. (405 aa)
W5K0L4_ASTMXMADS-box domain-containing protein. (479 aa)
LOC103033117Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (302 aa)
W5K1E9_ASTMXPlexin A2. (1888 aa)
Nfatc4Nuclear factor of activated T cells 4. (812 aa)
BCL2BCL2 apoptosis regulator. (201 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
W5K5H8_ASTMXPR domain containing 1b, with ZNF domain. (499 aa)
LOC103026658Plexin A1a. (1899 aa)
W5KA92_ASTMXDiscs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1806 aa)
prdm1PR domain containing 1a, with ZNF domain. (755 aa)
Lrp5Low density lipoprotein receptor-related protein 5. (1518 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
W5KHF9_ASTMXBTB (POZ) domain containing 7. (1046 aa)
W5KIU0_ASTMXMKS transition zone complex subunit 1. (528 aa)
Gbx2Gastrulation brain homeobox 2. (336 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
LOC103023715Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (862 aa)
W5KU03_ASTMXPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (288 aa)
W5KUR6_ASTMXPolycystic kidney disease 1a. (4355 aa)
arAndrogen receptor. (839 aa)
LOC103024223Secreted frizzled-related protein 2 like. (312 aa)
W5L1C8_ASTMXUncharacterized protein. (350 aa)
Gdf7Growth differentiation factor 7. (429 aa)
Dag1Dystroglycan 1. (874 aa)
socs2Suppressor of cytokine signaling 2. (211 aa)
plxna1Sema domain-containing protein. (1889 aa)
sars1Seryl-tRNA synthetase. (520 aa)
W5LD66_ASTMXMothers against decapentaplegic homolog. (573 aa)
W5LE75_ASTMXPlexin A3. (1197 aa)
tmem59lTransmembrane protein 59-like. (339 aa)
LOC103022359Mothers against decapentaplegic homolog. (587 aa)
LOC103029394Mothers against decapentaplegic homolog. (544 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
LOC103047157Suppressor of cytokine signaling 3a. (207 aa)
nrarpNOTCH regulated ankyrin repeat protein a. (112 aa)
LOC103024806Suppressor of cytokine signaling 3b. (224 aa)
LOC103036536SRY-box transcription factor 10. (483 aa)
ENSAMXP00000028486Mothers against decapentaplegic homolog. (493 aa)
ENSAMXP00000028909Sema domain-containing protein. (415 aa)
SRFSerum response factor. (527 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1801 aa)
setd2SET domain containing 2, histone lysine methyltransferase. (2886 aa)
sfrp5Secreted frizzled-related protein 5. (313 aa)
ENSAMXP00000030591WT1 transcription factor b. (391 aa)
greb1Growth regulating estrogen receptor binding 1. (1821 aa)
hs6st2Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (475 aa)
LOC107197257Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
ENSAMXP00000032821HMG box domain-containing protein. (458 aa)
ENSAMXP00000033131G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
LOC103027348Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (146 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (333 aa)
NRARPNOTCH regulated ankyrin repeat protein b. (107 aa)
LOC103028976Bone morphogenetic protein 2b. (445 aa)
fem1bFem-1 homolog b (C. elegans). (627 aa)
LOC103024868Serine peptidase inhibitor, Kunitz type 1 b. (470 aa)
nkx3-1NK3 homeobox 1. (202 aa)
ENSAMXP00000037031MKS transition zone complex subunit 1. (534 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (743 aa)
LOC103029324Bone morphogenetic protein 16. (430 aa)
ENSAMXP00000037899MADS-box domain-containing protein. (356 aa)
Plxna4Plexin A4. (1896 aa)
hhipHedgehog interacting protein. (693 aa)
LOC103045523SRY-box transcription factor 9a. (492 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
LOC103035447Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (265 aa)
ENSAMXP00000040763Uncharacterized protein. (233 aa)
ENSAMXP00000041303Uncharacterized protein. (196 aa)
LOC103042847Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (170 aa)
ENSAMXP00000041681Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (273 aa)
LOC103047885Serine peptidase inhibitor, Kunitz type, 2. (423 aa)
ENSAMXP00000042872Uncharacterized protein. (98 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (245 aa)
timelessTimeless circadian clock. (1256 aa)
LOC103038135Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (169 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
LOC103039548BCL2 apoptosis regulator. (218 aa)
lef1Lymphoid enhancer-binding factor 1. (384 aa)
TMED2Transmembrane p24 trafficking protein 2. (210 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
bmp4TGF_BETA_2 domain-containing protein. (481 aa)
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (359 aa)
ENSAMXP00000047894Endothelin 1. (162 aa)
wt1WT1 transcription factor a. (415 aa)
LOC111194998Transmembrane p24 trafficking protein 2. (202 aa)
ctnnbip1Catenin, beta interacting protein 1. (81 aa)
rspo2R-spondin 2. (244 aa)
LOC103045744Colony stimulating factor 1a (macrophage). (531 aa)
il10Interleukin 10. (182 aa)
ENSAMXP00000049950Sema domain-containing protein. (1875 aa)
ENSAMXP00000050201Pept_C1 domain-containing protein. (228 aa)
spint1Serine peptidase inhibitor, Kunitz type 1 a. (506 aa)
BTBD7BTB domain containing 7. (1122 aa)
LOC103037384Uncharacterized protein. (170 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
Dlg5Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1945 aa)
ilkIntegrin-linked kinase. (452 aa)
ENSAMXP00000054825Colony stimulating factor 1b (macrophage). (298 aa)
ENSAMXP00000053345MH1 domain-containing protein. (187 aa)
LOC103031663Transcription factor 21. (182 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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