50 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103034256	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (438 aa)
	f2r	Coagulation factor II (thrombin) receptor. (414 aa)
	ENSAMXP00000041739	Caveolae associated protein 2a. (238 aa)
	F2R	G_PROTEIN_RECEP_F1_2 domain-containing protein. (471 aa)
	LOC103023460	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (164 aa)
	LOC103035969	acidPPc domain-containing protein. (277 aa)
	LOC103047172	Caveolae associated protein 2b. (430 aa)
	ENSAMXP00000035483	G_PROTEIN_RECEP_F1_2 domain-containing protein. (355 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (840 aa)
	ENSAMXP00000032866	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
	plpp1	Phospholipid phosphatase 1a. (283 aa)
	LOC103033776	Phospholipid phosphatase 2a. (283 aa)
	LOC103029568	Caveolae associated protein 1b. (455 aa)
	LOC103028370	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	cavin4	Caveolae associated protein 4b. (316 aa)
	ENSAMXP00000027926	Scavenger receptor class B, member 1; Belongs to the CD36 family. (480 aa)
	ENSAMXP00000027661	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (221 aa)
	tgfbr2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
	LOC103021762	Neutral ceramidase. (738 aa)
	LOC103043623	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (173 aa)
	Lrrk2	Leucine-rich repeat kinase 2. (2537 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LOC103034507	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (425 aa)
	LOC103025270	Tissue factor pathway inhibitor. (270 aa)
	Lipe	Lipase, hormone-sensitive b. (804 aa)
	LOC103031589	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1183 aa)
	smpd2	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase). (430 aa)
	LOC103027319	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (423 aa)
	bves	Blood vessel epicardial substance. (359 aa)
	LOC103042559	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	LOC103026666	Caveolae associated protein 4a. (322 aa)
	ENSAMXP00000044990	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (259 aa)
	cln3	Battenin. (438 aa)
	cavin1	Caveolae associated protein 1a. (429 aa)
	neu3	Sialidase 3 (membrane sialidase), tandem duplicate 5. (396 aa)
	LOC103041890	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa)
	LOC103028797	Phospholipid phosphatase 2b. (326 aa)
	plvap	Plasmalemma vesicle associated protein b. (388 aa)
	LOC103038005	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	W5KQI5_ASTMX	Lipase, hormone-sensitive a. (682 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1228 aa)
	Akap6	Uncharacterized protein. (728 aa)
	mlc1	Modulator of VRAC current 1. (396 aa)
	LOC103029205	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (466 aa)
	Kif18a	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (909 aa)
	W5KF46_ASTMX	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
	W5KBZ4_ASTMX	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b. (480 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000027926	LOC103028370	ENSAMXP00000027926	ENSAMXP00000028604	Scavenger receptor class B, member 1; Belongs to the CD36 family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.532
ENSAMXP00000027926	cav3	ENSAMXP00000027926	ENSAMXP00000015604	Scavenger receptor class B, member 1; Belongs to the CD36 family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.532
ENSAMXP00000035483	F2R	ENSAMXP00000035483	ENSAMXP00000040854	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.900
ENSAMXP00000035483	f2r	ENSAMXP00000035483	ENSAMXP00000041788	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Coagulation factor II (thrombin) receptor.	0.906
ENSAMXP00000041739	LOC103028370	ENSAMXP00000041739	ENSAMXP00000028604	Caveolae associated protein 2a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.461
ENSAMXP00000041739	LOC103029568	ENSAMXP00000041739	ENSAMXP00000030998	Caveolae associated protein 2a.	Caveolae associated protein 1b.	0.422
ENSAMXP00000041739	cav3	ENSAMXP00000041739	ENSAMXP00000015604	Caveolae associated protein 2a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.461
ENSAMXP00000041739	cavin1	ENSAMXP00000041739	ENSAMXP00000052429	Caveolae associated protein 2a.	Caveolae associated protein 1a.	0.422
F2R	ENSAMXP00000035483	ENSAMXP00000040854	ENSAMXP00000035483	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.900
F2R	f2r	ENSAMXP00000040854	ENSAMXP00000041788	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Coagulation factor II (thrombin) receptor.	0.906
LOC103021762	LOC103033776	ENSAMXP00000018781	ENSAMXP00000031863	Neutral ceramidase.	Phospholipid phosphatase 2a.	0.909
LOC103021762	LOC103035969	ENSAMXP00000018781	ENSAMXP00000035586	Neutral ceramidase.	acidPPc domain-containing protein.	0.909
LOC103021762	plpp1	ENSAMXP00000018781	ENSAMXP00000031868	Neutral ceramidase.	Phospholipid phosphatase 1a.	0.909
LOC103021762	smpd2	ENSAMXP00000018781	ENSAMXP00000013996	Neutral ceramidase.	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase).	0.846
LOC103023460	LOC103027319	ENSAMXP00000038714	ENSAMXP00000014649	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.538
LOC103023460	LOC103028370	ENSAMXP00000038714	ENSAMXP00000028604	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.612
LOC103023460	LOC103029568	ENSAMXP00000038714	ENSAMXP00000030998	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1b.	0.756
LOC103023460	LOC103034256	ENSAMXP00000038714	ENSAMXP00000004202	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.538
LOC103023460	LOC103034507	ENSAMXP00000038714	ENSAMXP00000016534	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.538
LOC103023460	cav2	ENSAMXP00000038714	ENSAMXP00000035709	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.970