STRINGSTRING
Nlk Nlk W5JYR7_ASTMX W5JYR7_ASTMX LOC103034175 LOC103034175 Gdf3 Gdf3 LOC103021856 LOC103021856 W5K2H5_ASTMX W5K2H5_ASTMX Usp9x Usp9x tgfb1 tgfb1 smad6 smad6 LOC103027970 LOC103027970 LOC103026097 LOC103026097 Sirt1 Sirt1 LOC103027845 LOC103027845 pdcd4 pdcd4 itgb8 itgb8 W5JY11_ASTMX W5JY11_ASTMX TMEM100-2 TMEM100-2 Ccdc142 Ccdc142 Bmp7 Bmp7 ENSAMXP00000053993 ENSAMXP00000053993 ENSAMXP00000053345 ENSAMXP00000053345 appl1 appl1 tgfb2 tgfb2 fut8 fut8 ppm1l ppm1l LOC103047891 LOC103047891 LOC103039137 LOC103039137 ACVR1C ACVR1C LOC103042476 LOC103042476 smad7 smad7 LOC103044657 LOC103044657 ENSAMXP00000050762 ENSAMXP00000050762 bmp10 bmp10 ENSAMXP00000050414 ENSAMXP00000050414 LOC103025967 LOC103025967 LOC103029170 LOC103029170 LOC103041475 LOC103041475 ENSAMXP00000049079 ENSAMXP00000049079 LOC103038759 LOC103038759 hjv hjv LOC103039147 LOC103039147 ENSAMXP00000048023 ENSAMXP00000048023 LOC103035745 LOC103035745 ENSAMXP00000047553 ENSAMXP00000047553 skil skil LOC103027811 LOC103027811 Amh Amh LOC103041954 LOC103041954 bmp4 bmp4 LOC103025122 LOC103025122 LOC111197359 LOC111197359 lef1 lef1 ENSAMXP00000044621 ENSAMXP00000044621 INHBB INHBB ENSAMXP00000043951 ENSAMXP00000043951 LOC103042559 LOC103042559 Flcn Flcn ENSAMXP00000043778 ENSAMXP00000043778 sostdc1 sostdc1 hpgd hpgd LOC103033691 LOC103033691 LOC103029365 LOC103029365 ENSAMXP00000042051 ENSAMXP00000042051 gdf11 gdf11 smurf1 smurf1 ENSAMXP00000041684 ENSAMXP00000041684 LOC103040263 LOC103040263 ENSAMXP00000041392 ENSAMXP00000041392 LOC103027317 LOC103027317 ENSAMXP00000040747 ENSAMXP00000040747 smad1 smad1 ENSAMXP00000039138 ENSAMXP00000039138 TMEM100 TMEM100 LOC103025287 LOC103025287 LOC103041046 LOC103041046 LOC103030936 LOC103030936 LOC103029324 LOC103029324 fkbp8 fkbp8 LOC103022606 LOC103022606 LOC111195539 LOC111195539 LOC103045393 LOC103045393 LOC103028976 LOC103028976 TGFB1I1 TGFB1I1 smad2 smad2 LOC103027213 LOC103027213 LOC103045380 LOC103045380 rgmb rgmb INHBC INHBC MSX1 MSX1 LOC103021584 LOC103021584 bmper bmper tbx2 tbx2 ENSAMXP00000033639 ENSAMXP00000033639 ENSAMXP00000033251 ENSAMXP00000033251 LOC103028218 LOC103028218 ENSAMXP00000032700 ENSAMXP00000032700 LOC103031084 LOC103031084 LOC103035022 LOC103035022 ENSAMXP00000031415 ENSAMXP00000031415 LOC103027004 LOC103027004 bmpr1b bmpr1b bmp5 bmp5 rgma rgma LOC103031474 LOC103031474 bmp6 bmp6 Bmpr2 Bmpr2 sfrp5 sfrp5 LOC103038302 LOC103038302 ENSAMXP00000029792 ENSAMXP00000029792 slc33a1 slc33a1 LOC103042113 LOC103042113 LOC103032572 LOC103032572 ENSAMXP00000028486 ENSAMXP00000028486 LOC103035375 LOC103035375 bmp3 bmp3 LOC103024411 LOC103024411 LOC103029721 LOC103029721 cited1 cited1 LOC103021920 LOC103021920 cldn5 cldn5 W5LRC2_ASTMX W5LRC2_ASTMX acvr2b acvr2b LOC103023108 LOC103023108 tgfbr2 tgfbr2 W5LLR9_ASTMX W5LLR9_ASTMX W5LJD2_ASTMX W5LJD2_ASTMX LOC103031931 LOC103031931 LOC103029394 LOC103029394 ism2 ism2 mstn mstn LOC103022359 LOC103022359 W5LFP1_ASTMX W5LFP1_ASTMX W5LFM8_ASTMX W5LFM8_ASTMX W5LDM9_ASTMX W5LDM9_ASTMX W5LD66_ASTMX W5LD66_ASTMX tgfbr3 tgfbr3 LOC103047683 LOC103047683 LOC103027116 LOC103027116 nodal nodal nrros nrros SMURF2 SMURF2 W5L798_ASTMX W5L798_ASTMX LOC103034912 LOC103034912 tgfb3 tgfb3 LOC103046211 LOC103046211 inha inha W5L1R3_ASTMX W5L1R3_ASTMX Gdf7 Gdf7 LOC103034045 LOC103034045 LOC103036761 LOC103036761 LOC103043605 LOC103043605 W5KWH4_ASTMX W5KWH4_ASTMX LOC103024223 LOC103024223 LOC103023164 LOC103023164 smad5 smad5 ACVR1 ACVR1 gdf5 gdf5 W5KRV2_ASTMX W5KRV2_ASTMX LOC103024607 LOC103024607 LOC103032011 LOC103032011 W5KNU4_ASTMX W5KNU4_ASTMX LOC103040899 LOC103040899 W5KJ68_ASTMX W5KJ68_ASTMX W5KFJ0_ASTMX W5KFJ0_ASTMX W5KF46_ASTMX W5KF46_ASTMX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (515 aa)
W5JYR7_ASTMXLeft-right determination factor. (381 aa)
LOC103034175Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (496 aa)
Gdf3Growth differentiation factor 3. (360 aa)
LOC103021856Bone morphogenetic protein 2a. (405 aa)
W5K2H5_ASTMXMembrane associated guanylate kinase, WW and PDZ domain containing 2b. (1253 aa)
Usp9xUbiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2524 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
smad6Mothers against decapentaplegic homolog. (480 aa)
LOC103027970Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (478 aa)
LOC103026097Inhibin subunit beta B. (387 aa)
Sirt1Deacetylase sirtuin-type domain-containing protein. (802 aa)
LOC103027845SKI-like proto-oncogene b. (715 aa)
pdcd4Programmed cell death 4b. (470 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (790 aa)
W5JY11_ASTMXUncharacterized protein. (123 aa)
TMEM100-2Transmembrane protein 100. (147 aa)
Ccdc142Coiled-coil domain containing 142. (1032 aa)
Bmp7Bone morphogenetic protein 7b. (416 aa)
ENSAMXP00000053993Paxillin b. (523 aa)
ENSAMXP00000053345MH1 domain-containing protein. (187 aa)
appl1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (708 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
fut8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (584 aa)
ppm1lProtein phosphatase, Mg2+/Mn2+ dependent 1L. (361 aa)
LOC103047891Inhibitor of DNA binding 1, HLH protein. (131 aa)
LOC103039137Anti-dorsalizing morphogenic protein. (459 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
LOC103042476Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
smad7Mothers against decapentaplegic homolog. (390 aa)
LOC103044657RGM domain family, member D. (491 aa)
ENSAMXP00000050762Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
bmp10Bone morphogenetic protein 10. (492 aa)
ENSAMXP00000050414E3 ubiquitin-protein ligase. (752 aa)
LOC103025967Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
LOC103029170Zyxin. (618 aa)
LOC103041475Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1048 aa)
ENSAMXP00000049079RNA binding motif protein 4.3. (240 aa)
LOC103038759Golgi glycoprotein 1b. (1147 aa)
hjvHemojuvelin BMP co-receptor. (460 aa)
LOC103039147Spartin b. (611 aa)
ENSAMXP00000048023SH2 domain-containing protein. (147 aa)
LOC103035745Growth differentiation factor 6b. (398 aa)
ENSAMXP00000047553Nodal-related 1. (115 aa)
skilSKI-like proto-oncogene a. (681 aa)
LOC103027811Mothers against decapentaplegic homolog. (425 aa)
AmhAnti-Mullerian hormone. (551 aa)
LOC103041954Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
bmp4TGF_BETA_2 domain-containing protein. (481 aa)
LOC103025122Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
LOC111197359Uncharacterized protein. (492 aa)
lef1Lymphoid enhancer-binding factor 1. (384 aa)
ENSAMXP00000044621Protein phosphatase, Mg2+/Mn2+ dependent, 1La. (351 aa)
INHBBInhibin subunit beta B. (389 aa)
ENSAMXP00000043951Integrin beta. (210 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
FlcnFolliculin. (564 aa)
ENSAMXP00000043778BHLH domain-containing protein. (198 aa)
sostdc1Sclerostin domain containing 1a. (227 aa)
hpgd15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
LOC103033691Inhibin subunit beta Aa. (392 aa)
LOC103029365Uncharacterized protein. (1831 aa)
ENSAMXP00000042051Integrin beta; Belongs to the integrin beta chain family. (503 aa)
gdf11Growth differentiation factor 11. (409 aa)
smurf1E3 ubiquitin-protein ligase. (731 aa)
ENSAMXP00000041684TGF_BETA_2 domain-containing protein. (352 aa)
LOC103040263Growth differentiation factor 2. (404 aa)
ENSAMXP00000041392Protein phosphatase, Mg2+/Mn2+ dependent, 1La. (304 aa)
LOC103027317Gonadal somatic cell derived factor. (209 aa)
ENSAMXP00000040747Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (578 aa)
smad1Mothers against decapentaplegic homolog. (488 aa)
ENSAMXP00000039138Human immunodeficiency virus type I enhancer binding protein 1. (2540 aa)
TMEM100Uncharacterized protein. (139 aa)
LOC103025287Myostatin a. (348 aa)
LOC103041046Sclerostin domain containing 1b. (187 aa)
LOC103030936BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (265 aa)
LOC103029324Bone morphogenetic protein 16. (430 aa)
fkbp8Peptidylprolyl isomerase. (389 aa)
LOC103022606Zgc:56585; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (280 aa)
LOC111195539FAM83 domain-containing protein. (1505 aa)
LOC103045393BHLH domain-containing protein. (125 aa)
LOC103028976Bone morphogenetic protein 2b. (445 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (477 aa)
smad2Mothers against decapentaplegic homolog. (468 aa)
LOC103027213Hairy-related 2. (151 aa)
LOC103045380Growth differentiation factor 10b. (422 aa)
rgmbRepulsive guidance molecule BMP co-receptor b. (439 aa)
INHBCInhibin subunit beta C. (389 aa)
MSX1Msh homeobox 1. (201 aa)
LOC103021584Family with sequence similarity 83 member G. (888 aa)
bmperBMP binding endothelial regulator. (669 aa)
tbx2T-box transcription factor 2b. (692 aa)
ENSAMXP00000033639Mothers against decapentaplegic homolog. (425 aa)
ENSAMXP00000033251Bone morphogenetic protein 8a. (450 aa)
LOC103028218Golgi glycoprotein 1a. (1152 aa)
ENSAMXP00000032700Uncharacterized protein. (159 aa)
LOC103031084Bone morphogenetic protein 10, like. (462 aa)
LOC103035022Growth differentiation factor 6a. (406 aa)
ENSAMXP00000031415TGF_BETA_2 domain-containing protein. (180 aa)
LOC103027004Mothers against decapentaplegic homolog. (424 aa)
bmpr1bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
bmp5Bone morphogenetic protein 5. (445 aa)
rgmaRepulsive guidance molecule BMP co-receptor a. (460 aa)
LOC103031474V-ski avian sarcoma viral oncogene homolog b. (964 aa)
bmp6Bone morphogenetic protein 6. (427 aa)
Bmpr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1070 aa)
sfrp5Secreted frizzled-related protein 5. (313 aa)
LOC103038302Inhibin subunit beta Ab. (431 aa)
ENSAMXP00000029792Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
slc33a1Solute carrier family 33 member 1. (536 aa)
LOC103042113Bone morphogenetic protein 7a. (403 aa)
LOC103032572Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
ENSAMXP00000028486Mothers against decapentaplegic homolog. (493 aa)
LOC103035375Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
bmp3Bone morphogenetic protein 3. (442 aa)
LOC103024411Programmed cell death 4a. (468 aa)
LOC103029721BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b. (276 aa)
cited1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (155 aa)
LOC103021920JunE proto-oncogene, AP-1 transcription factor subunit. (353 aa)
cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
W5LRC2_ASTMXReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (338 aa)
acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOC103023108Southpaw. (418 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
W5LLR9_ASTMXTGF_BETA_2 domain-containing protein. (215 aa)
W5LJD2_ASTMXReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
LOC103031931Teratocarcinoma-derived growth factor 1. (183 aa)
LOC103029394Mothers against decapentaplegic homolog. (544 aa)
ism2Isthmin 2a. (457 aa)
mstnMyostatin b. (435 aa)
LOC103022359Mothers against decapentaplegic homolog. (587 aa)
W5LFP1_ASTMXMembrane associated guanylate kinase, WW and PDZ domain containing 2a. (1064 aa)
W5LFM8_ASTMXJade family PHD finger 2. (853 aa)
W5LDM9_ASTMXTGF-beta activated kinase 1/MAP3K7 binding protein 1. (537 aa)
W5LD66_ASTMXMothers against decapentaplegic homolog. (573 aa)
tgfbr3Transforming growth factor, beta receptor III. (853 aa)
LOC103047683Leupaxin. (413 aa)
LOC103027116Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
nodalNodal-related 2. (373 aa)
nrrosNegative regulator of reactive oxygen species. (683 aa)
SMURF2E3 ubiquitin-protein ligase. (761 aa)
W5L798_ASTMXYes-associated protein 1. (431 aa)
LOC103034912ZP domain-containing protein. (905 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
LOC103046211V-ski avian sarcoma viral oncogene homolog a. (790 aa)
inhaInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (344 aa)
W5L1R3_ASTMXUSP domain-containing protein; Belongs to the peptidase C19 family. (2529 aa)
Gdf7Growth differentiation factor 7. (429 aa)
LOC103034045Uncharacterized protein. (645 aa)
LOC103036761Growth differentiation factor 10a. (437 aa)
LOC103043605Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (580 aa)
W5KWH4_ASTMXInositol polyphosphate phosphatase-like 1a. (931 aa)
LOC103024223Secreted frizzled-related protein 2 like. (312 aa)
LOC103023164Bone morphogenetic protein 15. (397 aa)
smad5Mothers against decapentaplegic homolog. (464 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (679 aa)
gdf5Growth differentiation factor 5. (431 aa)
W5KRV2_ASTMXCadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (757 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
LOC103032011Leucine rich repeat containing 32. (680 aa)
W5KNU4_ASTMXSphingomyelin phosphodiesterase 3, neutral. (613 aa)
LOC103040899Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
W5KJ68_ASTMXPeptidylprolyl isomerase. (501 aa)
W5KFJ0_ASTMXMothers against decapentaplegic homolog. (468 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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