99 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103041996	ADAM metallopeptidase domain 17b. (841 aa)
	mib2	Mindbomb E3 ubiquitin protein ligase 2. (1017 aa)
	TMEM100-2	Transmembrane protein 100. (147 aa)
	ift74	Intraflagellar transport 74. (599 aa)
	ENSAMXP00000054497	RING-type domain-containing protein. (539 aa)
	grip2	Glutamate receptor interacting protein 2b. (1124 aa)
	Fsd1	Fibronectin type III and SPRY domain containing 1. (546 aa)
	gmds	GDP-mannose 4,6-dehydratase. (377 aa)
	ENSAMXP00000053261	annotation not available (35 aa)
	LOC103043594	Hairy-related 1. (307 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	Cfap58	Uncharacterized protein. (92 aa)
	LOC103025197	Notch receptor 1b. (2477 aa)
	Sel1l	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (819 aa)
	Dll3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (708 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	hey2	Hes-related family bHLH transcription factor with YRPW motif 2. (315 aa)
	LOC103023492	Si:dkey-3h3.3. (439 aa)
	DTX1	Deltex E3 ubiquitin ligase 1. (635 aa)
	ENSAMXP00000047819	Beta-1,3-N-acetylglucosaminyltransferase. (356 aa)
	LOC103044865	Si:ch211-270g19.5. (52 aa)
	mecp2	Methyl CpG binding protein 2. (612 aa)
	ENSAMXP00000046776	DTC domain-containing protein. (217 aa)
	chac1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (206 aa)
	ENSAMXP00000046422	DTC domain-containing protein. (410 aa)
	LOC103033594	APH1B gamma secretase subunit. (258 aa)
	ENSAMXP00000045440	Uncharacterized protein. (183 aa)
	dlx6	Distal-less homeobox 6a. (247 aa)
	traf7	TNF receptor-associated factor 7. (688 aa)
	LOC103042559	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	ENSAMXP00000043778	BHLH domain-containing protein. (198 aa)
	gsx1	Homeobox domain-containing protein. (273 aa)
	ENSAMXP00000043377	Glutamate receptor interacting protein 2a. (1001 aa)
	psenen	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	LOC103047857	Glutamic-oxaloacetic transaminase 1 like 1. (410 aa)
	LOC103031228	Nuclear receptor interacting protein 2. (305 aa)
	ENSAMXP00000041605	Si:ch1073-396h14.1. (694 aa)
	dtx3	Zgc:66440. (372 aa)
	snai2	Snail family zinc finger 2. (259 aa)
	ENSAMXP00000039539	Hairy-related 1. (280 aa)
	ENSAMXP00000039487	Zgc:114200. (259 aa)
	ENSAMXP00000039291	RING-type domain-containing protein. (200 aa)
	TMEM100	Uncharacterized protein. (139 aa)
	Itgb1bp1	Integrin beta 1 binding protein 1. (184 aa)
	timp4	TIMP metallopeptidase inhibitor 4, tandem duplicate 3. (223 aa)
	Mib1	Mindbomb E3 ubiquitin protein ligase 1. (1027 aa)
	LOC103031245	Protein tyrosine phosphatase 4A3a. (173 aa)
	LOC103030559	Deltex 4, E3 ubiquitin ligase b. (733 aa)
	hey1	Hes-related family bHLH transcription factor with YRPW motif 1. (323 aa)
	lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (457 aa)
	maml1	Mastermind-like transcriptional coactivator 1. (1070 aa)
	LOC103027213	Hairy-related 2. (151 aa)
	LOC103031354	Hairy-related 5. (232 aa)
	NRARP	NOTCH regulated ankyrin repeat protein b. (107 aa)
	LOC103027184	ADAM metallopeptidase domain 10b. (792 aa)
	ENSAMXP00000032700	Uncharacterized protein. (159 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
	ENSAMXP00000031485	Si:ch73-78o10.1. (154 aa)
	LOC103024849	Hes related family bHLH transcription factor with YRPW motif like. (331 aa)
	susd5	Sushi domain containing 5. (715 aa)
	LOC103027782	Nuclear receptor subfamily 0, group B, member 2a. (257 aa)
	ENSAMXP00000030535	RING-type domain-containing protein. (203 aa)
	LOC103029087	Protein tyrosine phosphatase 4A3b. (173 aa)
	nle1	Notchless homolog 1 (Drosophila). (476 aa)
	ENSAMXP00000029721	Mastermind-like transcriptional coactivator 3. (1154 aa)
	NCSTN	Nicastrin. (704 aa)
	nrarp	NOTCH regulated ankyrin repeat protein a. (112 aa)
	LOC103029720	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1257 aa)
	tgfbr2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (486 aa)
	pkd2	Polycystic kidney disease 2. (903 aa)
	W5LD95_ASTMX	ADAM metallopeptidase domain 17a. (675 aa)
	dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
	LOC103034623	Notch receptor 1a. (2450 aa)
	bap1	Ubiquitin carboxyl-terminal hydrolase. (768 aa)
	LOC103047839	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (460 aa)
	LOC103045468	Nuclear receptor subfamily 0, group B, member 2b. (267 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (591 aa)
	LOC103043423	ADAM metallopeptidase domain 10a. (793 aa)
	LOC103043413	Nuclear receptor subfamily 1, group H, member 5. (495 aa)
	LOC103026639	Deltex 4, E3 ubiquitin ligase a. (706 aa)
	LOC103029567	Recombination signal binding protein for immunoglobulin kappa J region a. (502 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region b. (494 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1229 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (870 aa)
	LOC103024607	Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
	W5KLW4_ASTMX	Uncharacterized protein. (1195 aa)
	LOC103031030	Hairy-related 11. (286 aa)
	LOC103038960	Deltex 2, E3 ubiquitin ligase. (657 aa)
	W5KGW2_ASTMX	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (600 aa)
	GALNT11	Polypeptide N-acetylgalactosaminyltransferase. (593 aa)
	W5KF46_ASTMX	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
	W5K8B8_ASTMX	Thrombospondin-type laminin G domain and EAR repeats b. (446 aa)
	W5K581_ASTMX	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (436 aa)
	pofut1	Protein O-fucosyltransferase 1. (396 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	got1	Aspartate aminotransferase. (410 aa)
	W5K0Q2_ASTMX	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (726 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DTX1	LOC103025197	ENSAMXP00000048072	ENSAMXP00000051793	Deltex E3 ubiquitin ligase 1.	Notch receptor 1b.	0.823
DTX1	LOC103034623	ENSAMXP00000048072	ENSAMXP00000015021	Deltex E3 ubiquitin ligase 1.	Notch receptor 1a.	0.823
Dll3	LOC103025197	ENSAMXP00000050702	ENSAMXP00000051793	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1b.	0.976
Dll3	LOC103027184	ENSAMXP00000050702	ENSAMXP00000032930	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ADAM metallopeptidase domain 10b.	0.415
Dll3	LOC103029567	ENSAMXP00000050702	ENSAMXP00000011492	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.510
Dll3	LOC103034623	ENSAMXP00000050702	ENSAMXP00000015021	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1a.	0.976
Dll3	LOC103043423	ENSAMXP00000050702	ENSAMXP00000012699	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ADAM metallopeptidase domain 10a.	0.415
Dll3	Mib1	ENSAMXP00000050702	ENSAMXP00000037923	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.588
Dll3	dll1	ENSAMXP00000050702	ENSAMXP00000015776	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
Dll3	dll4	ENSAMXP00000050702	ENSAMXP00000017668	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
Dll3	rbpj	ENSAMXP00000050702	ENSAMXP00000011127	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region b.	0.510
ENSAMXP00000029721	LOC103025197	ENSAMXP00000029721	ENSAMXP00000051793	Mastermind-like transcriptional coactivator 3.	Notch receptor 1b.	0.666
ENSAMXP00000029721	LOC103029567	ENSAMXP00000029721	ENSAMXP00000011492	Mastermind-like transcriptional coactivator 3.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.909
ENSAMXP00000029721	LOC103034623	ENSAMXP00000029721	ENSAMXP00000015021	Mastermind-like transcriptional coactivator 3.	Notch receptor 1a.	0.666
ENSAMXP00000029721	dll4	ENSAMXP00000029721	ENSAMXP00000017668	Mastermind-like transcriptional coactivator 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.431
ENSAMXP00000029721	maml1	ENSAMXP00000029721	ENSAMXP00000035961	Mastermind-like transcriptional coactivator 3.	Mastermind-like transcriptional coactivator 1.	0.924
ENSAMXP00000029721	rbpj	ENSAMXP00000029721	ENSAMXP00000011127	Mastermind-like transcriptional coactivator 3.	Recombination signal binding protein for immunoglobulin kappa J region b.	0.888
ENSAMXP00000039291	LOC103025197	ENSAMXP00000039291	ENSAMXP00000051793	RING-type domain-containing protein.	Notch receptor 1b.	0.669
ENSAMXP00000039291	LOC103034623	ENSAMXP00000039291	ENSAMXP00000015021	RING-type domain-containing protein.	Notch receptor 1a.	0.669
ENSAMXP00000039487	LOC103025197	ENSAMXP00000039487	ENSAMXP00000051793	Zgc:114200.	Notch receptor 1b.	0.836