61 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5K3H2_ASTMX	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (418 aa)
	kiaa0586	Si:ch211-185a18.2. (1626 aa)
	iqub	IQ motif and ubiquitin domain containing. (764 aa)
	tmem231	Transmembrane protein 231. (309 aa)
	ro60	Ro60, Y RNA binding protein. (542 aa)
	Gli3	GLI family zinc finger 3. (1434 aa)
	W5K4Q5_ASTMX	Hedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (505 aa)
	LOC103032733	Zgc:77752. (621 aa)
	Rb1	Retinoblastoma 1. (882 aa)
	W5KF46_ASTMX	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
	W5KIU0_ASTMX	MKS transition zone complex subunit 1. (528 aa)
	W5KJ68_ASTMX	Peptidylprolyl isomerase. (501 aa)
	ptchd1	Patched domain containing 1. (888 aa)
	W5KQ23_ASTMX	Patched 2. (1330 aa)
	ptchd4	Patched domain containing 4. (913 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1320 aa)
	ssna1	Sjogren syndrome nuclear autoantigen 1. (113 aa)
	bbs7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1522 aa)
	LOC103035832	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (416 aa)
	W5L312_ASTMX	Intraflagellar transport 80 homolog (Chlamydomonas). (768 aa)
	boc	BOC cell adhesion associated, oncogene regulated. (1045 aa)
	sufu	Suppressor of fused homolog. (483 aa)
	ift27	Intraflagellar transport 27 homolog (Chlamydomonas). (186 aa)
	stil	STIL centriolar assembly protein. (1303 aa)
	W5LK41_ASTMX	Cell adhesion associated, oncogene regulated. (1109 aa)
	tgfbr2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
	LOC103028990	GLI family zinc finger 2b. (1488 aa)
	stk36	Serine/threonine kinase 36 (fused homolog, Drosophila). (1329 aa)
	LOC103036215	Zgc:112294. (217 aa)
	ulk3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
	Wdr19	WD repeat domain 19. (1339 aa)
	Gli1	GLI family zinc finger 1. (1480 aa)
	ENSAMXP00000032700	Uncharacterized protein. (159 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (840 aa)
	LOC103027213	Hairy-related 2. (151 aa)
	nsdhl	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (345 aa)
	LOC103032897	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	fkbp8	Peptidylprolyl isomerase. (389 aa)
	ENSAMXP00000036990	Hint domain-containing protein. (153 aa)
	ENSAMXP00000037031	MKS transition zone complex subunit 1. (534 aa)
	ENSAMXP00000037874	Zgc:63587; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (363 aa)
	hspb11	Zgc:158640. (171 aa)
	gli2	GLI family zinc finger 2a. (1447 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa)
	Wdpcp	Uncharacterized protein. (98 aa)
	ttc26	Tetratricopeptide repeat domain 26. (557 aa)
	ENSAMXP00000043778	BHLH domain-containing protein. (198 aa)
	LOC103042559	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (445 aa)
	ENSAMXP00000045682	Cilia and flagella associated protein 410. (241 aa)
	ENSAMXP00000046843	Uncharacterized protein. (683 aa)
	Rest	RE1-silencing transcription factor. (1235 aa)
	ptch1	Patched 1. (1506 aa)
	b9d1	B9 protein domain 1. (205 aa)
	tmem17	Transmembrane protein 17. (191 aa)
	arl13b	ADP-ribosylation factor-like 13b. (410 aa)
	disp2	Dispatched homolog 2 (Drosophila). (1479 aa)
	ENSAMXP00000054649	Signal peptide, CUB domain, EGF-like 2. (976 aa)
	septin2	Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (370 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000036990	W5K4Q5_ASTMX	ENSAMXP00000036990	ENSAMXP00000002566	Hint domain-containing protein.	Hedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family.	0.590
ENSAMXP00000036990	W5KQ23_ASTMX	ENSAMXP00000036990	ENSAMXP00000009685	Hint domain-containing protein.	Patched 2.	0.808
ENSAMXP00000036990	W5LK41_ASTMX	ENSAMXP00000036990	ENSAMXP00000020203	Hint domain-containing protein.	Cell adhesion associated, oncogene regulated.	0.788
ENSAMXP00000036990	boc	ENSAMXP00000036990	ENSAMXP00000015138	Hint domain-containing protein.	BOC cell adhesion associated, oncogene regulated.	0.788
ENSAMXP00000036990	disp1	ENSAMXP00000036990	ENSAMXP00000013518	Hint domain-containing protein.	Dispatched homolog 1 (Drosophila).	0.873
ENSAMXP00000036990	disp2	ENSAMXP00000036990	ENSAMXP00000053647	Hint domain-containing protein.	Dispatched homolog 2 (Drosophila).	0.795
ENSAMXP00000036990	ptch1	ENSAMXP00000036990	ENSAMXP00000047043	Hint domain-containing protein.	Patched 1.	0.808
ENSAMXP00000036990	smo	ENSAMXP00000036990	ENSAMXP00000035127	Hint domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.670
ENSAMXP00000037031	Wdpcp	ENSAMXP00000037031	ENSAMXP00000042016	MKS transition zone complex subunit 1.	Uncharacterized protein.	0.434
ENSAMXP00000037031	b9d1	ENSAMXP00000037031	ENSAMXP00000047683	MKS transition zone complex subunit 1.	B9 protein domain 1.	0.887
ENSAMXP00000037031	bbs7	ENSAMXP00000037031	ENSAMXP00000013455	MKS transition zone complex subunit 1.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.420
ENSAMXP00000037031	septin2	ENSAMXP00000037031	ENSAMXP00000055099	MKS transition zone complex subunit 1.	Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.404
ENSAMXP00000037031	tmem231	ENSAMXP00000037031	ENSAMXP00000001800	MKS transition zone complex subunit 1.	Transmembrane protein 231.	0.596
ENSAMXP00000037874	b9d1	ENSAMXP00000037874	ENSAMXP00000047683	Zgc:63587; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	B9 protein domain 1.	0.582
ENSAMXP00000046843	Gli3	ENSAMXP00000046843	ENSAMXP00000002546	Uncharacterized protein.	GLI family zinc finger 3.	0.402
ENSAMXP00000046843	smo	ENSAMXP00000046843	ENSAMXP00000035127	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.820
ENSAMXP00000054649	W5K4Q5_ASTMX	ENSAMXP00000054649	ENSAMXP00000002566	Signal peptide, CUB domain, EGF-like 2.	Hedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family.	0.472
ENSAMXP00000054649	shh	ENSAMXP00000054649	ENSAMXP00000028286	Signal peptide, CUB domain, EGF-like 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.547
Gli1	LOC103032897	ENSAMXP00000031825	ENSAMXP00000036419	GLI family zinc finger 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.696
Gli1	LOC103035832	ENSAMXP00000031825	ENSAMXP00000013537	GLI family zinc finger 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.425