(42 nodes) Potassium channel regulator activity network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103036582	WNK lysine deficient protein kinase 4b. (1614 aa)
	KCNIP4	Potassium voltage-gated channel interacting protein 4. (186 aa)
	LOC103030666	Aldo_ket_red domain-containing protein. (397 aa)
	W5KCE6_ASTMX	Si:dkey-52j6.3. (327 aa)
	W5KHJ6_ASTMX	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (243 aa)
	PDZD4	PDZ domain containing 4. (754 aa)
	W5KPY6_ASTMX	Dipeptidyl-peptidase 6a; Belongs to the peptidase S9B family. (765 aa)
	Lrrc38	Leucine rich repeat containing 38b. (290 aa)
	sgk3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
	W5LH02_ASTMX	Dipeptidyl-peptidase 6b; Belongs to the peptidase S9B family. (781 aa)
	amigo3	Adhesion molecule with Ig-like domain 3. (457 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (119 aa)
	amigo1	Adhesion molecule with Ig-like domain 1. (495 aa)
	LOC103044601	Leucine rich repeat containing 38a. (291 aa)
	LOC103021848	Potassium large conductance calcium-activated channel, subfamily M, beta member 2. (284 aa)
	KCNAB1	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (366 aa)
	LOC103035084	PDZ domain-containing protein. (870 aa)
	KCNIP2	Kv channel interacting protein 2. (258 aa)
	ENSAMXP00000030997	Si:ch211-145b13.5. (240 aa)
	LOC103032552	Aldo_ket_red domain-containing protein. (472 aa)
	ywhae	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa)
	LOC103042220	Si:ch211-247n2.1. (288 aa)
	LOC103026456	Kv channel interacting protein 3b, calsenilin. (439 aa)
	ENSAMXP00000036136	Si:dkey-43k4.5; Belongs to the potassium channel family. (506 aa)
	KCNAB3	Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (432 aa)
	ENSAMXP00000037024	Uncharacterized protein. (1347 aa)
	LOC103024127	Uncharacterized protein. (361 aa)
	LOC103023460	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	KCNIP1	Potassium voltage-gated channel interacting protein 1. (225 aa)
	ENSAMXP00000038960	Uncharacterized protein. (124 aa)
	ENSAMXP00000040250	Aldo_ket_red domain-containing protein. (331 aa)
	ENSAMXP00000042655	Ig-like domain-containing protein. (492 aa)
	LOC103038802	Protein kinase domain-containing protein. (1685 aa)
	ENSAMXP00000045644	Protein kinase domain-containing protein. (377 aa)
	LOC103038317	WNK lysine deficient protein kinase 2. (2670 aa)
	LOC103024145	Kv channel interacting protein 1 b. (225 aa)
	ENSAMXP00000048966	WNK lysine deficient protein kinase 2. (2447 aa)
	ENSAMXP00000049261	Potassium voltage-gated channel, Isk-related family, member 4. (172 aa)
	LOC103022732	Uncharacterized protein; Belongs to the peptidase S9B family. (805 aa)
	LOC103022586	Potassium voltage-gated channel, shaker-related subfamily, beta member 1 b. (399 aa)
	ENSAMXP00000053021	WNK lysine deficient protein kinase 1b. (2468 aa)
	DPP10	Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (795 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000036136	ENSAMXP00000040250	ENSAMXP00000036136	ENSAMXP00000040250	Si:dkey-43k4.5; Belongs to the potassium channel family.	Aldo_ket_red domain-containing protein.	0.628
ENSAMXP00000036136	KCNAB1	ENSAMXP00000036136	ENSAMXP00000028669	Si:dkey-43k4.5; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1.	0.588
ENSAMXP00000036136	KCNAB3	ENSAMXP00000036136	ENSAMXP00000036560	Si:dkey-43k4.5; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily A regulatory beta subunit 3.	0.628
ENSAMXP00000036136	LOC103022586	ENSAMXP00000036136	ENSAMXP00000052676	Si:dkey-43k4.5; Belongs to the potassium channel family.	Potassium voltage-gated channel, shaker-related subfamily, beta member 1 b.	0.588
ENSAMXP00000036136	LOC103030666	ENSAMXP00000036136	ENSAMXP00000003911	Si:dkey-43k4.5; Belongs to the potassium channel family.	Aldo_ket_red domain-containing protein.	0.588
ENSAMXP00000036136	LOC103032552	ENSAMXP00000036136	ENSAMXP00000032066	Si:dkey-43k4.5; Belongs to the potassium channel family.	Aldo_ket_red domain-containing protein.	0.588
ENSAMXP00000038960	ENSAMXP00000049261	ENSAMXP00000038960	ENSAMXP00000049261	Uncharacterized protein.	Potassium voltage-gated channel, Isk-related family, member 4.	0.509
ENSAMXP00000040250	ENSAMXP00000036136	ENSAMXP00000040250	ENSAMXP00000036136	Aldo_ket_red domain-containing protein.	Si:dkey-43k4.5; Belongs to the potassium channel family.	0.628
ENSAMXP00000048966	sgk3	ENSAMXP00000048966	ENSAMXP00000014113	WNK lysine deficient protein kinase 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.414
ENSAMXP00000049261	ENSAMXP00000038960	ENSAMXP00000049261	ENSAMXP00000038960	Potassium voltage-gated channel, Isk-related family, member 4.	Uncharacterized protein.	0.509
ENSAMXP00000049261	KCNE2	ENSAMXP00000049261	ENSAMXP00000026770	Potassium voltage-gated channel, Isk-related family, member 4.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.578
KCNAB1	ENSAMXP00000036136	ENSAMXP00000028669	ENSAMXP00000036136	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1.	Si:dkey-43k4.5; Belongs to the potassium channel family.	0.588
KCNAB3	ENSAMXP00000036136	ENSAMXP00000036560	ENSAMXP00000036136	Potassium voltage-gated channel subfamily A regulatory beta subunit 3.	Si:dkey-43k4.5; Belongs to the potassium channel family.	0.628
KCNE2	ENSAMXP00000049261	ENSAMXP00000026770	ENSAMXP00000049261	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel, Isk-related family, member 4.	0.578
KCNE2	LOC103023460	ENSAMXP00000026770	ENSAMXP00000038714	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.459
LOC103021848	LOC103042220	ENSAMXP00000028407	ENSAMXP00000032784	Potassium large conductance calcium-activated channel, subfamily M, beta member 2.	Si:ch211-247n2.1.	0.902
LOC103022586	ENSAMXP00000036136	ENSAMXP00000052676	ENSAMXP00000036136	Potassium voltage-gated channel, shaker-related subfamily, beta member 1 b.	Si:dkey-43k4.5; Belongs to the potassium channel family.	0.588
LOC103023460	KCNE2	ENSAMXP00000038714	ENSAMXP00000026770	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.459
LOC103030666	ENSAMXP00000036136	ENSAMXP00000003911	ENSAMXP00000036136	Aldo_ket_red domain-containing protein.	Si:dkey-43k4.5; Belongs to the potassium channel family.	0.588
LOC103032552	ENSAMXP00000036136	ENSAMXP00000032066	ENSAMXP00000036136	Aldo_ket_red domain-containing protein.	Si:dkey-43k4.5; Belongs to the potassium channel family.	0.588