(57 nodes) Phenol-containing compound metabolic process network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5K8E8_ASTMX	Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase). (446 aa)
	btbd9	BTB (POZ) domain containing 9. (604 aa)
	dct	Dopachrome tautomerase. (518 aa)
	BCL2	BCL2 apoptosis regulator. (201 aa)
	duox1	Dual oxidase. (1602 aa)
	CPQ	Carboxypeptidase Q. (317 aa)
	LOC103044416	Sulfotransferase; Belongs to the sulfotransferase 1 family. (299 aa)
	SLC16A2	Solute carrier family 16 member 2. (556 aa)
	trpc1	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family. (798 aa)
	gch1	GTP cyclohydrolase 1. (267 aa)
	LOC103039919	Amine oxidase. (543 aa)
	LOC103039548	BCL2 apoptosis regulator. (218 aa)
	LOC103043615	Sulfotransferase; Belongs to the sulfotransferase 1 family. (298 aa)
	LOC111192652	RING-type domain-containing protein. (433 aa)
	th	Tyrosine hydroxylase. (517 aa)
	maob	Amine oxidase. (522 aa)
	LOC103040843	Tyrosinase. (539 aa)
	LOC103043231	GTP cyclohydrolase 2. (241 aa)
	ENSAMXP00000035470	Uncharacterized protein; Belongs to the synuclein family. (66 aa)
	LOC103041557	Transmembrane O-methyltransferase. (259 aa)
	iyd	Iodotyrosine deiodinase. (296 aa)
	LOC103044736	Sulfotransferase; Belongs to the sulfotransferase 1 family. (292 aa)
	TYR	Tyrosinase. (537 aa)
	LOC107197600	Sulfotransferase; Belongs to the sulfotransferase 1 family. (292 aa)
	hdc	Histidine decarboxylase. (639 aa)
	LOC103025693	Tryptophan hydroxylase 1b. (481 aa)
	ddt	D-dopachrome tautomerase. (118 aa)
	Prkn	Parkin RBR E3 ubiquitin protein ligase. (417 aa)
	moxd1	Monooxygenase, DBH-like 1. (641 aa)
	ENSAMXP00000033131	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	LOC107197257	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (376 aa)
	Sncb	Synuclein, beta; Belongs to the synuclein family. (160 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1801 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (155 aa)
	DIO3	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (256 aa)
	LOC103027103	Tyrosinase-related protein 1b. (526 aa)
	W5LQG8_ASTMX	Tyrosinase related protein 1. (479 aa)
	fah	Fumarylacetoacetase. (449 aa)
	W5LJL2_ASTMX	Dopa decarboxylase. (453 aa)
	Dio2	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (257 aa)
	tg	Thyroglobulin. (2760 aa)
	tph1	Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a. (483 aa)
	W5LF28_ASTMX	NADPH oxidase, EF-hand calcium binding domain 5. (722 aa)
	W5LBQ6_ASTMX	Catechol-O-methyltransferase a. (250 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (240 aa)
	LOC111192690	Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
	W5L5C0_ASTMX	Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
	LOC103028227	Sulfotransferase; Belongs to the sulfotransferase 1 family. (299 aa)
	W5L422_ASTMX	Tyrosine hydroxylase 2. (472 aa)
	Dao	D-amino-acid oxidase, tandem duplicate 3. (415 aa)
	Sncaip	Synuclein, alpha interacting protein. (862 aa)
	oca2	CitMHS domain-containing protein. (857 aa)
	LOC107197817	Ring finger protein 180. (502 aa)
	crym	Crystallin, mu. (312 aa)
	LOC103025507	Monooxygenase, DBH-like 1, like. (573 aa)
	Dbh	Dopamine beta-hydroxylase (dopamine beta-monooxygenase). (588 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIO3	Dio2	ENSAMXP00000025709	ENSAMXP00000019169	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.462
DIO3	iyd	ENSAMXP00000025709	ENSAMXP00000033738	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodotyrosine deiodinase.	0.410
Dao	crym	ENSAMXP00000014101	ENSAMXP00000009182	D-amino-acid oxidase, tandem duplicate 3.	Crystallin, mu.	0.481
Dbh	LOC103039919	ENSAMXP00000006770	ENSAMXP00000044363	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Amine oxidase.	0.929
Dbh	LOC103041557	ENSAMXP00000006770	ENSAMXP00000033773	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Transmembrane O-methyltransferase.	0.914
Dbh	PNMT	ENSAMXP00000006770	ENSAMXP00000015844	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Phenylethanolamine N-methyltransferase.	0.616
Dbh	W5LBQ6_ASTMX	ENSAMXP00000006770	ENSAMXP00000017268	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Catechol-O-methyltransferase a.	0.926
Dbh	W5LJL2_ASTMX	ENSAMXP00000006770	ENSAMXP00000020024	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Dopa decarboxylase.	0.515
Dbh	hdc	ENSAMXP00000006770	ENSAMXP00000048835	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Histidine decarboxylase.	0.448
Dbh	maob	ENSAMXP00000006770	ENSAMXP00000040090	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Amine oxidase.	0.929
Dbh	th	ENSAMXP00000006770	ENSAMXP00000041315	Dopamine beta-hydroxylase (dopamine beta-monooxygenase).	Tyrosine hydroxylase.	0.590
Dio2	DIO3	ENSAMXP00000019169	ENSAMXP00000025709	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.462
Dio2	SLC16A2	ENSAMXP00000019169	ENSAMXP00000051402	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Solute carrier family 16 member 2.	0.425
Dio2	tg	ENSAMXP00000019169	ENSAMXP00000019072	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Thyroglobulin.	0.569
ENSAMXP00000033131	LOC107197257	ENSAMXP00000033131	ENSAMXP00000032052	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC103025507	PNMT	ENSAMXP00000006774	ENSAMXP00000015844	Monooxygenase, DBH-like 1, like.	Phenylethanolamine N-methyltransferase.	0.485
LOC103025507	W5LJL2_ASTMX	ENSAMXP00000006774	ENSAMXP00000020024	Monooxygenase, DBH-like 1, like.	Dopa decarboxylase.	0.448
LOC103025507	hdc	ENSAMXP00000006774	ENSAMXP00000048835	Monooxygenase, DBH-like 1, like.	Histidine decarboxylase.	0.448
LOC103025507	th	ENSAMXP00000006774	ENSAMXP00000041315	Monooxygenase, DBH-like 1, like.	Tyrosine hydroxylase.	0.433
LOC103025693	LOC103039919	ENSAMXP00000049086	ENSAMXP00000044363	Tryptophan hydroxylase 1b.	Amine oxidase.	0.498