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W5KF46_ASTMX W5KF46_ASTMX W5KCP4_ASTMX W5KCP4_ASTMX LOC103037777 LOC103037777 Pdgfra Pdgfra LTBP3 LTBP3 LOC103034175 LOC103034175 W5K7M8_ASTMX W5K7M8_ASTMX ENSAMXP00000054777 ENSAMXP00000054777 Sec61b Sec61b fgfbp3 fgfbp3 ACVR1C ACVR1C TWSG1 TWSG1 Fgfr3 Fgfr3 ntrk3 ntrk3 ENSAMXP00000049295 ENSAMXP00000049295 wfikkn1 wfikkn1 LOC103038759 LOC103038759 ENSAMXP00000048061 ENSAMXP00000048061 ENSAMXP00000047318 ENSAMXP00000047318 ENSAMXP00000047286 ENSAMXP00000047286 LOC103038483 LOC103038483 LOC103041954 LOC103041954 LOC103025650 LOC103025650 ENSAMXP00000045776 ENSAMXP00000045776 LOC103042559 LOC103042559 LOC103045197 LOC103045197 LOC103042160 LOC103042160 ENSAMXP00000042293 ENSAMXP00000042293 ENSAMXP00000041770 ENSAMXP00000041770 ENSAMXP00000040877 ENSAMXP00000040877 igfbp7 igfbp7 ENSAMXP00000040747 ENSAMXP00000040747 ENSAMXP00000040343 ENSAMXP00000040343 LOC103047724 LOC103047724 Gpc2 Gpc2 ENSAMXP00000038144 ENSAMXP00000038144 ENSAMXP00000037601 ENSAMXP00000037601 ENSAMXP00000035305 ENSAMXP00000035305 LOC103032641 LOC103032641 LOC103041103 LOC103041103 LOC103032076 LOC103032076 Fgfrl1 Fgfrl1 ENSAMXP00000033716 ENSAMXP00000033716 ENSAMXP00000033669 ENSAMXP00000033669 LOC103028218 LOC103028218 LOC103031826 LOC103031826 LOC103042872 LOC103042872 LOC103023912 LOC103023912 il6r il6r ENSAMXP00000030964 ENSAMXP00000030964 nrp1 nrp1 ccn1 ccn1 ENSAMXP00000029929 ENSAMXP00000029929 twsg1 twsg1 Ltbp2 Ltbp2 sort1 sort1 Ntrk1 Ntrk1 igfals igfals LOC103042468 LOC103042468 LOC103043606 LOC103043606 W5LRN3_ASTMX W5LRN3_ASTMX W5LQH2_ASTMX W5LQH2_ASTMX W5LP11_ASTMX W5LP11_ASTMX tgfbr2 tgfbr2 hax1 hax1 W5LJD2_ASTMX W5LJD2_ASTMX LOC103042183 LOC103042183 Gpc6 Gpc6 Igf2r Igf2r LOC103027116 LOC103027116 LOC103024700 LOC103024700 RHBDF2 RHBDF2 nrros nrros W5L834_ASTMX W5L834_ASTMX W5L7P6_ASTMX W5L7P6_ASTMX tgfb3 tgfb3 flt3 flt3 Api5 Api5 LOC103022197 LOC103022197 igfbp2 igfbp2 LOC103034045 LOC103034045 fgfbp2 fgfbp2 W5KY53_ASTMX W5KY53_ASTMX LOC103033971 LOC103033971 ntrk2 ntrk2 ACVR1 ACVR1 LOC103043694 LOC103043694 W5KRB5_ASTMX W5KRB5_ASTMX LOC103023250 LOC103023250 LOC103032011 LOC103032011 Rhbdf1 Rhbdf1 fibp fibp fgfr4 fgfr4 LOC103044160 LOC103044160 LOC103025715 LOC103025715
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
W5KCP4_ASTMXLatent transforming growth factor beta binding protein 1. (1455 aa)
LOC103037777Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (528 aa)
PdgfraPlatelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (995 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1247 aa)
LOC103034175Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (496 aa)
W5K7M8_ASTMXUncharacterized protein. (997 aa)
ENSAMXP00000054777Uncharacterized protein. (165 aa)
Sec61bProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (117 aa)
fgfbp3Fibroblast growth factor binding protein 3. (320 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
Fgfr3Fibroblast growth factor receptor. (815 aa)
ntrk3Tyrosine-protein kinase receptor. (826 aa)
ENSAMXP00000049295Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (231 aa)
wfikkn1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (565 aa)
LOC103038759Golgi glycoprotein 1b. (1147 aa)
ENSAMXP00000048061Fibroblast growth factor receptor. (806 aa)
ENSAMXP00000047318Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (248 aa)
ENSAMXP00000047286Insulin-like growth factor binding protein 1b. (255 aa)
LOC103038483EF-hand domain-containing protein. (111 aa)
LOC103041954Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
LOC103025650Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (553 aa)
ENSAMXP00000045776Nerve growth factor receptor a (TNFR superfamily, member 16). (419 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
LOC103045197Insulin-like growth factor binding protein 6b. (213 aa)
LOC103042160Centrosomal protein 57. (483 aa)
ENSAMXP00000042293Neurotrophin receptor associated death domain. (353 aa)
ENSAMXP00000041770Neurotrophic tyrosine kinase, receptor, type 3a. (539 aa)
ENSAMXP00000040877Uncharacterized protein. (117 aa)
igfbp7Insulin-like growth factor binding protein 7. (283 aa)
ENSAMXP00000040747Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (578 aa)
ENSAMXP00000040343Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (342 aa)
LOC103047724Sortilin. (818 aa)
Gpc2Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (520 aa)
ENSAMXP00000038144Interleukin 2 receptor, beta. (457 aa)
ENSAMXP00000037601LIF receptor subunit alpha a. (931 aa)
ENSAMXP00000035305Glypican 6b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (530 aa)
LOC103032641Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (526 aa)
LOC103041103HtrA serine peptidase 1b. (471 aa)
LOC103032076Info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a. (566 aa)
Fgfrl1Fibroblast growth factor receptor like 1a. (497 aa)
ENSAMXP00000033716Insulin-like growth factor binding protein 2b. (277 aa)
ENSAMXP00000033669Fibroblast growth factor receptor like 1b. (483 aa)
LOC103028218Golgi glycoprotein 1a. (1152 aa)
LOC103031826LIF receptor subunit alpha b. (898 aa)
LOC103042872Insulin-like growth factor binding protein 5a. (270 aa)
LOC103023912Kazal-type serine peptidase inhibitor domain 3. (300 aa)
il6rInterleukin 6 receptor. (591 aa)
ENSAMXP00000030964Uncharacterized protein. (95 aa)
nrp1Neuropilin; Belongs to the neuropilin family. (924 aa)
ccn1Cellular communication network factor 1. (372 aa)
ENSAMXP00000029929Interleukin 6 signal transducer. (815 aa)
twsg1Twisted gastrulation BMP signaling modulator 1a. (223 aa)
Ltbp2Uncharacterized protein. (689 aa)
sort1Sortilin. (844 aa)
Ntrk1Tyrosine-protein kinase receptor. (788 aa)
igfalsInsulin-like growth factor binding protein, acid labile subunit. (598 aa)
LOC103042468Uncharacterized protein. (347 aa)
LOC103043606Uncharacterized protein. (347 aa)
W5LRN3_ASTMXLRRNT domain-containing protein. (908 aa)
W5LQH2_ASTMXFibroblast growth factor binding protein 2b. (358 aa)
W5LP11_ASTMXUncharacterized protein. (1626 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
hax1HCLS1 associated protein X-1. (306 aa)
W5LJD2_ASTMXReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
LOC103042183HtrA serine peptidase 1a. (481 aa)
Gpc6Glypican 6a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (528 aa)
Igf2rInsulin-like growth factor 2 receptor. (2458 aa)
LOC103027116Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
LOC103024700WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b. (561 aa)
RHBDF2Rhomboid 5 homolog 2. (825 aa)
nrrosNegative regulator of reactive oxygen species. (683 aa)
W5L834_ASTMXFibroblast growth factor receptor. (735 aa)
W5L7P6_ASTMXGlypican 1a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (567 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
flt3Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (983 aa)
Api5Apoptosis inhibitor 5. (522 aa)
LOC103022197Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (202 aa)
igfbp2Insulin-like growth factor binding protein 2a. (282 aa)
LOC103034045Uncharacterized protein. (645 aa)
fgfbp2Fibroblast growth factor binding protein 2a. (262 aa)
W5KY53_ASTMXNeurotrophic receptor tyrosine kinase 3. (307 aa)
LOC103033971Nerve growth factor receptor b. (425 aa)
ntrk2Tyrosine-protein kinase receptor. (796 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (679 aa)
LOC103043694Uncharacterized protein. (465 aa)
W5KRB5_ASTMXGlypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (533 aa)
LOC103023250Interleukin 11 receptor, alpha. (399 aa)
LOC103032011Leucine rich repeat containing 32. (680 aa)
Rhbdf1Rhomboid 5 homolog 1a (Drosophila). (747 aa)
fibpFibroblast growth factor (acidic) intracellular binding protein a. (357 aa)
fgfr4Fibroblast growth factor receptor 4. (938 aa)
LOC103044160Tyrosine-protein kinase receptor. (813 aa)
LOC103025715Fibroblast growth factor (acidic) intracellular binding protein b. (357 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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