(23 nodes) Thyroid gland development network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
	LOC103038588	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1295 aa)
	W5K0L4_ASTMX	MADS-box domain-containing protein. (479 aa)
	HESX1	HESX homeobox 1. (151 aa)
	W5KCI8_ASTMX	Paired box 2b. (345 aa)
	W5KLW4_ASTMX	Uncharacterized protein. (1195 aa)
	pax8	Paired box 8. (552 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1229 aa)
	tg	Thyroglobulin. (2760 aa)
	LOC103029720	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1257 aa)
	LOC103025318	NK2 homeobox 5. (313 aa)
	SRF	Serum response factor. (527 aa)
	LOC107197257	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	hand2	Heart and neural crest derivatives expressed 2. (200 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSAMXP00000033131	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	pax5	Paired box 5. (427 aa)
	ENSAMXP00000037899	MADS-box domain-containing protein. (356 aa)
	LOC103035447	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (265 aa)
	ENSAMXP00000045440	Uncharacterized protein. (183 aa)
	ENSAMXP00000047894	Endothelin 1. (162 aa)
	pax2	Paired box 2a. (475 aa)
	Tal1	T-cell acute lymphocytic leukemia 1. (371 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000033131	ENSAMXP00000047894	ENSAMXP00000033131	ENSAMXP00000047894	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.978
ENSAMXP00000033131	LOC107197257	ENSAMXP00000033131	ENSAMXP00000032052	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.902
ENSAMXP00000037899	LOC103025318	ENSAMXP00000037899	ENSAMXP00000028592	MADS-box domain-containing protein.	NK2 homeobox 5.	0.456
ENSAMXP00000047894	ENSAMXP00000033131	ENSAMXP00000047894	ENSAMXP00000033131	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.978
ENSAMXP00000047894	LOC107197257	ENSAMXP00000047894	ENSAMXP00000032052	Endothelin 1.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.971
ENSAMXP00000047894	fgf8	ENSAMXP00000047894	ENSAMXP00000032559	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.568
ENSAMXP00000047894	hand2	ENSAMXP00000047894	ENSAMXP00000032184	Endothelin 1.	Heart and neural crest derivatives expressed 2.	0.574
ENSAMXP00000047894	jag1	ENSAMXP00000047894	ENSAMXP00000011031	Endothelin 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.477
JAG1	jag1	ENSAMXP00000031759	ENSAMXP00000011031	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.901
LOC103025318	ENSAMXP00000037899	ENSAMXP00000028592	ENSAMXP00000037899	NK2 homeobox 5.	MADS-box domain-containing protein.	0.456
LOC103025318	LOC103038588	ENSAMXP00000028592	ENSAMXP00000000180	NK2 homeobox 5.	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.520
LOC103025318	SRF	ENSAMXP00000028592	ENSAMXP00000028964	NK2 homeobox 5.	Serum response factor.	0.456
LOC103025318	W5K0L4_ASTMX	ENSAMXP00000028592	ENSAMXP00000001124	NK2 homeobox 5.	MADS-box domain-containing protein.	0.456
LOC103025318	fgf8	ENSAMXP00000028592	ENSAMXP00000032559	NK2 homeobox 5.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.446
LOC103025318	hand2	ENSAMXP00000028592	ENSAMXP00000032184	NK2 homeobox 5.	Heart and neural crest derivatives expressed 2.	0.855
LOC103035447	LOC103038588	ENSAMXP00000040217	ENSAMXP00000000180	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.966
LOC103038588	LOC103025318	ENSAMXP00000000180	ENSAMXP00000028592	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	NK2 homeobox 5.	0.520
LOC103038588	LOC103035447	ENSAMXP00000000180	ENSAMXP00000040217	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	0.966
LOC103038588	Tal1	ENSAMXP00000000180	ENSAMXP00000054373	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	T-cell acute lymphocytic leukemia 1.	0.522
LOC103038588	fgf8	ENSAMXP00000000180	ENSAMXP00000032559	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.815