(39 nodes) Midbrain development network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	phox2a	Paired like homeobox 2A. (288 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC103021536	Homeobox protein engrailed-like. (260 aa)
	Wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (558 aa)
	MSX1	Msh homeobox 1. (201 aa)
	ENSAMXP00000034556	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	Fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	pax5	Paired box 5. (427 aa)
	ryk	Receptor like tyrosine kinase. (627 aa)
	en1	Homeobox protein engrailed-like. (227 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	LOC103025417	Diencephalon/mesencephalon homeobox 1a. (383 aa)
	Wdr73	WD repeat domain 73. (378 aa)
	ENSAMXP00000041224	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (295 aa)
	OTX2-2	Orthodenticle homeobox 2. (298 aa)
	LOC103030680	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. (898 aa)
	ENSAMXP00000048061	Fibroblast growth factor receptor. (806 aa)
	LOC103037976	Homeobox protein engrailed-like. (286 aa)
	LOC103035169	Ubiquinol-cytochrome c reductase, complex III subunit VII. (82 aa)
	fst	Follistatin a. (347 aa)
	katnb1	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (725 aa)
	pax2	Paired box 2a. (475 aa)
	Dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1945 aa)
	W5K0Q2_ASTMX	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (726 aa)
	W5KA92_ASTMX	Discs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1806 aa)
	W5KCI8_ASTMX	Paired box 2b. (345 aa)
	LOC103022374	Transcription factor 7 like 1b. (583 aa)
	LOC103040257	Uncharacterized protein. (816 aa)
	W5KGW2_ASTMX	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (600 aa)
	pax8	Paired box 8. (552 aa)
	Med12	Mediator complex subunit 12. (2026 aa)
	dmbx1	Diencephalon/mesencephalon homeobox 1b. (418 aa)
	kdm7a	Lysine (K)-specific demethylase 7Ab. (884 aa)
	Gdf7	Growth differentiation factor 7. (429 aa)
	LOC103029625	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	ENSAMXP00000028064	Uncharacterized protein. (482 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (903 aa)
	LOC103035751	Follistatin b. (362 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	LOC103030680	ENSAMXP00000031306	ENSAMXP00000046775	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.901
ENSAMXP00000028064	Med12	ENSAMXP00000028064	ENSAMXP00000011922	Uncharacterized protein.	Mediator complex subunit 12.	0.421
ENSAMXP00000028064	Wdr73	ENSAMXP00000028064	ENSAMXP00000039912	Uncharacterized protein.	WD repeat domain 73.	0.451
ENSAMXP00000034556	Fgf3	ENSAMXP00000034556	ENSAMXP00000035243	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.456
ENSAMXP00000034556	LOC103029625	ENSAMXP00000034556	ENSAMXP00000017031	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.454
ENSAMXP00000034556	Wnt2b	ENSAMXP00000034556	ENSAMXP00000032808	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.454
ENSAMXP00000034556	fgf8	ENSAMXP00000034556	ENSAMXP00000032559	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.522
ENSAMXP00000034556	ryk	ENSAMXP00000034556	ENSAMXP00000037893	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.781
ENSAMXP00000041224	LOC103029625	ENSAMXP00000041224	ENSAMXP00000017031	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.454
ENSAMXP00000041224	Wnt2b	ENSAMXP00000041224	ENSAMXP00000032808	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.454
ENSAMXP00000041224	fgf8	ENSAMXP00000041224	ENSAMXP00000032559	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.417
ENSAMXP00000041224	ryk	ENSAMXP00000041224	ENSAMXP00000037893	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.781
ENSAMXP00000048061	Fgf3	ENSAMXP00000048061	ENSAMXP00000035243	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.681
ENSAMXP00000048061	fgf16	ENSAMXP00000048061	ENSAMXP00000054913	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.739
ENSAMXP00000048061	fgf8	ENSAMXP00000048061	ENSAMXP00000032559	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.865
Fgf3	ENSAMXP00000034556	ENSAMXP00000035243	ENSAMXP00000034556	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.456
Fgf3	ENSAMXP00000048061	ENSAMXP00000035243	ENSAMXP00000048061	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.681
Fgf3	fgf16	ENSAMXP00000035243	ENSAMXP00000054913	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
Fgf3	fgf8	ENSAMXP00000035243	ENSAMXP00000032559	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.829
Fgf3	pax2	ENSAMXP00000035243	ENSAMXP00000052522	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box 2a.	0.408