STRINGSTRING
smad6 smad6 W5KF46_ASTMX W5KF46_ASTMX W5KFJ0_ASTMX W5KFJ0_ASTMX LOC103024607 LOC103024607 tgfb3 tgfb3 tgfbr2 tgfbr2 LOC103038514 LOC103038514 LOC103042559 LOC103042559 smad7 smad7 tgfb1 tgfb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smad6Mothers against decapentaplegic homolog. (480 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
W5KFJ0_ASTMXMothers against decapentaplegic homolog. (468 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
LOC103038514LRRCT domain-containing protein. (327 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
smad7Mothers against decapentaplegic homolog. (390 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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