(29 nodes) Glutamate receptor binding network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	c18h16orf70	Si:dkey-102f14.5. (414 aa)
	W5KW74_ASTMX	Sequestosome 1. (427 aa)
	W5KZY3_ASTMX	SH3 and multiple ankyrin repeat domains 2b. (1779 aa)
	SYNDIG1	Synapse differentiation inducing 1. (280 aa)
	W5L9N9_ASTMX	Shisa family member 7a. (370 aa)
	W5LKX0_ASTMX	N-ethylmaleimide-sensitive factor b. (728 aa)
	W5LN37_ASTMX	SH3 and multiple ankyrin repeat domains 2a. (1756 aa)
	LOC103038528	Neuropilin (NRP) and tolloid (TLL)-like 1. (531 aa)
	LOC103025423	Shisa family member 7. (643 aa)
	igsf11	Immunoglobulin superfamily member 11. (458 aa)
	homer2	Homer scaffold protein 2. (355 aa)
	neto2	Neuropilin (NRP) and tolloid (TLL)-like 2b. (560 aa)
	LOC103042184	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (335 aa)
	LOC103038576	SH3 and multiple ankyrin repeat domains 3b. (1639 aa)
	ENSAMXP00000039061	Homer scaffold protein 3b. (364 aa)
	LOC103031660	WH1 domain-containing protein. (361 aa)
	HOMER1	Homer scaffold protein 1. (371 aa)
	ENSAMXP00000043377	Glutamate receptor interacting protein 2a. (1001 aa)
	LOC103040208	Homer scaffold protein 1b. (398 aa)
	ENSAMXP00000045469	SH3 and multiple ankyrin repeat domains 1. (1896 aa)
	neto1	Neuropilin (NRP) and tolloid (TLL)-like 1, like. (540 aa)
	LOC103039925	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (335 aa)
	LOC103037152	N-ethylmaleimide-sensitive factor a. (753 aa)
	LOC103029856	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (324 aa)
	Shisa6	Uncharacterized protein. (138 aa)
	ENSAMXP00000050086	Uncharacterized protein. (328 aa)
	ENSAMXP00000052510	Uncharacterized protein. (78 aa)
	grip2	Glutamate receptor interacting protein 2b. (1124 aa)
	LOC103034665	Neuropilin (NRP) and tolloid (TLL)-like 2b. (563 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000039061	ENSAMXP00000045469	ENSAMXP00000039061	ENSAMXP00000045469	Homer scaffold protein 3b.	SH3 and multiple ankyrin repeat domains 1.	0.534
ENSAMXP00000039061	HOMER1	ENSAMXP00000039061	ENSAMXP00000042378	Homer scaffold protein 3b.	Homer scaffold protein 1.	0.801
ENSAMXP00000039061	LOC103038576	ENSAMXP00000039061	ENSAMXP00000038092	Homer scaffold protein 3b.	SH3 and multiple ankyrin repeat domains 3b.	0.534
ENSAMXP00000039061	LOC103040208	ENSAMXP00000039061	ENSAMXP00000043564	Homer scaffold protein 3b.	Homer scaffold protein 1b.	0.803
ENSAMXP00000039061	W5KZY3_ASTMX	ENSAMXP00000039061	ENSAMXP00000013145	Homer scaffold protein 3b.	SH3 and multiple ankyrin repeat domains 2b.	0.405
ENSAMXP00000039061	W5LN37_ASTMX	ENSAMXP00000039061	ENSAMXP00000021249	Homer scaffold protein 3b.	SH3 and multiple ankyrin repeat domains 2a.	0.534
ENSAMXP00000045469	ENSAMXP00000039061	ENSAMXP00000045469	ENSAMXP00000039061	SH3 and multiple ankyrin repeat domains 1.	Homer scaffold protein 3b.	0.534
ENSAMXP00000045469	HOMER1	ENSAMXP00000045469	ENSAMXP00000042378	SH3 and multiple ankyrin repeat domains 1.	Homer scaffold protein 1.	0.584
ENSAMXP00000045469	LOC103031660	ENSAMXP00000045469	ENSAMXP00000041883	SH3 and multiple ankyrin repeat domains 1.	WH1 domain-containing protein.	0.534
ENSAMXP00000045469	LOC103040208	ENSAMXP00000045469	ENSAMXP00000043564	SH3 and multiple ankyrin repeat domains 1.	Homer scaffold protein 1b.	0.584
ENSAMXP00000050086	Shisa6	ENSAMXP00000050086	ENSAMXP00000048586	Uncharacterized protein.	Uncharacterized protein.	0.773
HOMER1	ENSAMXP00000039061	ENSAMXP00000042378	ENSAMXP00000039061	Homer scaffold protein 1.	Homer scaffold protein 3b.	0.801
HOMER1	ENSAMXP00000045469	ENSAMXP00000042378	ENSAMXP00000045469	Homer scaffold protein 1.	SH3 and multiple ankyrin repeat domains 1.	0.584
HOMER1	LOC103031660	ENSAMXP00000042378	ENSAMXP00000041883	Homer scaffold protein 1.	WH1 domain-containing protein.	0.800
HOMER1	LOC103038576	ENSAMXP00000042378	ENSAMXP00000038092	Homer scaffold protein 1.	SH3 and multiple ankyrin repeat domains 3b.	0.584
HOMER1	W5KZY3_ASTMX	ENSAMXP00000042378	ENSAMXP00000013145	Homer scaffold protein 1.	SH3 and multiple ankyrin repeat domains 2b.	0.529
HOMER1	W5LN37_ASTMX	ENSAMXP00000042378	ENSAMXP00000021249	Homer scaffold protein 1.	SH3 and multiple ankyrin repeat domains 2a.	0.584
LOC103031660	ENSAMXP00000045469	ENSAMXP00000041883	ENSAMXP00000045469	WH1 domain-containing protein.	SH3 and multiple ankyrin repeat domains 1.	0.534
LOC103031660	HOMER1	ENSAMXP00000041883	ENSAMXP00000042378	WH1 domain-containing protein.	Homer scaffold protein 1.	0.800
LOC103031660	LOC103038576	ENSAMXP00000041883	ENSAMXP00000038092	WH1 domain-containing protein.	SH3 and multiple ankyrin repeat domains 3b.	0.534