STRINGSTRING
BCL2 BCL2 W5KF46_ASTMX W5KF46_ASTMX W5KNU4_ASTMX W5KNU4_ASTMX LOC103022868 LOC103022868 lepr lepr ar ar arid2 arid2 ube3a ube3a W5L1C8_ASTMX W5L1C8_ASTMX hlx hlx W5L312_ASTMX W5L312_ASTMX LOC103042940 LOC103042940 LOC103029625 LOC103029625 ecm1 ecm1 tgfbr2 tgfbr2 Diexf Diexf LOC103045279 LOC103045279 LOC103043606 LOC103043606 LOC103042468 LOC103042468 ENSAMXP00000027455 ENSAMXP00000027455 Fxn Fxn LOC103025318 LOC103025318 LOC103028370 LOC103028370 ENSAMXP00000031442 ENSAMXP00000031442 Wnt2b Wnt2b zmpste24 zmpste24 sav1 sav1 fgf7 fgf7 LOC103042886 LOC103042886 stc1 stc1 ENSAMXP00000040343 ENSAMXP00000040343 LOC103043824 LOC103043824 Ostn Ostn ENSAMXP00000042872 ENSAMXP00000042872 anxa6 anxa6 LOC103042559 LOC103042559 rap1b rap1b LOC103039548 LOC103039548 ENSAMXP00000046100 ENSAMXP00000046100 ENSAMXP00000046843 ENSAMXP00000046843 rspo2 rspo2 map2k4 map2k4 LOC107197240 LOC107197240 hey2 hey2 ENSAMXP00000049828 ENSAMXP00000049828 Adprhl1 Adprhl1 LOC103031087 LOC103031087 LOC103042476 LOC103042476 tbx20 tbx20 rap1a rap1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2BCL2 apoptosis regulator. (201 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
W5KNU4_ASTMXSphingomyelin phosphodiesterase 3, neutral. (613 aa)
LOC103022868RAP1A, member of RAS oncogene family b. (185 aa)
leprLeptin receptor. (1117 aa)
arAndrogen receptor. (839 aa)
arid2AT rich interactive domain 2 (ARID, RFX-like). (1711 aa)
ube3aUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (873 aa)
W5L1C8_ASTMXUncharacterized protein. (350 aa)
hlxH2.0-like homeo box 1 (Drosophila). (374 aa)
W5L312_ASTMXIntraflagellar transport 80 homolog (Chlamydomonas). (768 aa)
LOC103042940Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (425 aa)
LOC103029625Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
ecm1Extracellular matrix protein 1b. (490 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
DiexfUTP25 small subunit processor component. (468 aa)
LOC103045279Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
LOC103043606Uncharacterized protein. (347 aa)
LOC103042468Uncharacterized protein. (347 aa)
ENSAMXP00000027455Immediate early response 3 interacting protein 1. (82 aa)
FxnFrataxin. (125 aa)
LOC103025318NK2 homeobox 5. (313 aa)
LOC103028370Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
ENSAMXP00000031442Uncharacterized protein. (75 aa)
Wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (558 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (470 aa)
sav1Salvador family WW domain containing protein 1. (405 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
LOC103042886Cholinergic receptor, nicotinic, alpha 1 (muscle). (481 aa)
stc1Stanniocalcin 1. (250 aa)
ENSAMXP00000040343Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (342 aa)
LOC103043824Leptin a. (172 aa)
OstnOsteocrin. (134 aa)
ENSAMXP00000042872Uncharacterized protein. (98 aa)
anxa6Annexin. (667 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
rap1bRAP1B, member of RAS oncogene family. (184 aa)
LOC103039548BCL2 apoptosis regulator. (218 aa)
ENSAMXP00000046100Divergent protein kinase domain 2Ab. (323 aa)
ENSAMXP00000046843Uncharacterized protein. (683 aa)
rspo2R-spondin 2. (244 aa)
map2k4Mitogen-activated protein kinase kinase 4a; Belongs to the protein kinase superfamily. (422 aa)
LOC107197240BHLH domain-containing protein. (244 aa)
hey2Hes-related family bHLH transcription factor with YRPW motif 2. (315 aa)
ENSAMXP00000049828Uncharacterized protein. (122 aa)
Adprhl1ADP-ribosylhydrolase like 1. (301 aa)
LOC103031087Divergent protein kinase domain 2Aa. (433 aa)
LOC103042476Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
tbx20T-box transcription factor 20. (441 aa)
rap1aRAP1A, member of RAS oncogene family a. (195 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.