(82 nodes) Retrograde transport, endosome to Golgi network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	plekhj1	Pleckstrin homology domain containing, family J member 1. (156 aa)
	Snx8	Sorting nexin 8a. (585 aa)
	vps54	VPS54 subunit of GARP complex. (1007 aa)
	vti1b	Vesicle transport through interaction with t-SNAREs 1B. (225 aa)
	ENSAMXP00000054998	Sorting nexin 1a. (648 aa)
	ENSAMXP00000030482	Uncharacterized protein. (600 aa)
	stx16	Syntaxin 16; Belongs to the syntaxin family. (302 aa)
	Washc2c	CAP-ZIP_m domain-containing protein. (1362 aa)
	Vps51	VPS51 subunit of GARP complex. (825 aa)
	W5K380_ASTMX	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1808 aa)
	Cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1587 aa)
	W5K3Q3_ASTMX	Si:dkey-28n18.9. (357 aa)
	W5K407_ASTMX	Phosphoinositide kinase, FYVE finger containing. (1923 aa)
	snx6	Sorting nexin; Involved in several stages of intracellular trafficking. (407 aa)
	TMEM87B	Transmembrane protein 87B. (579 aa)
	LOC103034698	Vacuolar protein sorting 26 homolog B, like. (332 aa)
	W5K8H2_ASTMX	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1553 aa)
	prepl	Prolyl endopeptidase like. (729 aa)
	tbc1d23	TBC1 domain family, member 23. (730 aa)
	LOC103041138	Syntaxin 5A; Belongs to the syntaxin family. (302 aa)
	Rhobtb3	Si:dkey-6b12.5. (619 aa)
	W5KII5_ASTMX	TBC1 domain family, member 5. (753 aa)
	W5KKM1_ASTMX	Uncharacterized protein. (638 aa)
	Heatr5a	HEAT repeat containing 5a. (1999 aa)
	tmem87a	Uncharacterized protein. (564 aa)
	vps26a	VPS26, retromer complex component A. (327 aa)
	LOC103046327	PH domain-containing protein. (271 aa)
	stx10	Syntaxin 10. (254 aa)
	Snx2	Sorting nexin 2. (509 aa)
	W5L103_ASTMX	Uncharacterized protein. (85 aa)
	LOC103034087	TBC1 domain family, member 10C. (1263 aa)
	Ankfy1	Ankyrin repeat and FYVE domain containing 1. (1191 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1362 aa)
	cln5	CLN5 intracellular trafficking protein. (338 aa)
	LOC103028140	Golgi transport 1Bb. (138 aa)
	RIC1	RIC1 homolog, RAB6A GEF complex partner 1. (1410 aa)
	dctn1	Dynactin 1b. (1246 aa)
	vps35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	Tbc1d10a	TBC1 domain family, member 10Ab. (384 aa)
	W5LKK8_ASTMX	Si:dkey-246g23.2. (259 aa)
	rbsn	Rabenosyn, RAB effector. (783 aa)
	W5LMA4_ASTMX	Trafficking protein particle complex 10. (1230 aa)
	arl1	ADP-ribosylation factor-like 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	Heatr5b	HEAT repeat containing 5B. (2065 aa)
	LOC103025908	RAB9A, member RAS oncogene family. (202 aa)
	rab9a	RAB9A, member RAS oncogene family. (201 aa)
	LOC103026314	RAB9B, member RAS oncogene family. (224 aa)
	rgp1	GP1 homolog, RAB6A GEF complex partner 1. (386 aa)
	vti1a	Vesicle transport through interaction with t-SNAREs 1A. (224 aa)
	vps29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
	vps53	VPS53 subunit of GARP complex. (866 aa)
	vamp3	Vesicle-associated membrane protein 3 (cellubrevin). (102 aa)
	Snx5	Sorting nexin; Involved in several stages of intracellular trafficking. (449 aa)
	LOC103025548	TBC1 domain family, member 10Aa. (647 aa)
	LOC103036351	RAB6B, member RAS oncogene family b. (283 aa)
	ENSAMXP00000037168	Uncharacterized protein. (138 aa)
	snx12	Sorting nexin 12. (164 aa)
	ENSAMXP00000034196	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1497 aa)
	SLC66A2	Solute carrier family 66 member 2. (270 aa)
	Rab41	RAB41, member RAS oncogene family. (196 aa)
	arfrp1	ADP-ribosylation factor related protein 1. (201 aa)
	ENSAMXP00000041196	Uncharacterized protein. (225 aa)
	Rnf126	Ring finger protein 126. (373 aa)
	ENSAMXP00000045361	Uncharacterized protein. (54 aa)
	washc1	WAS protein family homolog 1. (523 aa)
	tbc1d10b	TBC1 domain family, member 10b. (919 aa)
	LOC103034056	Golgi transport 1Ba. (126 aa)
	LOC103044774	Zgc:153733. (273 aa)
	LOC103044300	Sorting nexin 1b. (525 aa)
	vps26b	VPS26, retromer complex component B. (331 aa)
	stx6	Syntaxin 6; Belongs to the syntaxin family. (270 aa)
	LOC103024680	RAB6B, member RAS oncogene family a. (208 aa)
	LOC103029055	Dynactin domain-containing protein. (1226 aa)
	golt1a	Golgi transport 1A. (132 aa)
	BET1L	Bet1 golgi vesicular membrane trafficking protein like. (110 aa)
	Gcc2	GRIP domain-containing protein. (1472 aa)
	rab6a	RAB6A, member RAS oncogene family. (224 aa)
	ENSAMXP00000050689	BTB domain-containing protein. (197 aa)
	LOC103027691	Syntaxin 5A, like. (347 aa)
	ENSAMXP00000051278	Si:ch211-193c2.2. (208 aa)
	snx3	Sorting nexin 3. (162 aa)
	ENSAMXP00000053361	VPS52 subunit of GARP complex. (523 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankfy1	BET1L	ENSAMXP00000016201	ENSAMXP00000049700	Ankyrin repeat and FYVE domain containing 1.	Bet1 golgi vesicular membrane trafficking protein like.	0.427
Ankfy1	ENSAMXP00000050689	ENSAMXP00000016201	ENSAMXP00000050689	Ankyrin repeat and FYVE domain containing 1.	BTB domain-containing protein.	0.481
Ankfy1	Rhobtb3	ENSAMXP00000016201	ENSAMXP00000006816	Ankyrin repeat and FYVE domain containing 1.	Si:dkey-6b12.5.	0.481
Ankfy1	rbsn	ENSAMXP00000016201	ENSAMXP00000020468	Ankyrin repeat and FYVE domain containing 1.	Rabenosyn, RAB effector.	0.772
Ankfy1	vps29	ENSAMXP00000016201	ENSAMXP00000029237	Ankyrin repeat and FYVE domain containing 1.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.509
Ankfy1	vps35	ENSAMXP00000016201	ENSAMXP00000019093	Ankyrin repeat and FYVE domain containing 1.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.473
BET1L	Ankfy1	ENSAMXP00000049700	ENSAMXP00000016201	Bet1 golgi vesicular membrane trafficking protein like.	Ankyrin repeat and FYVE domain containing 1.	0.427
BET1L	LOC103027691	ENSAMXP00000049700	ENSAMXP00000050911	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 5A, like.	0.996
BET1L	LOC103041138	ENSAMXP00000049700	ENSAMXP00000005843	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 5A; Belongs to the syntaxin family.	0.996
BET1L	W5K380_ASTMX	ENSAMXP00000049700	ENSAMXP00000002041	Bet1 golgi vesicular membrane trafficking protein like.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.645
BET1L	stx10	ENSAMXP00000049700	ENSAMXP00000012459	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 10.	0.482
BET1L	stx16	ENSAMXP00000049700	ENSAMXP00000034699	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 16; Belongs to the syntaxin family.	0.545
BET1L	stx6	ENSAMXP00000049700	ENSAMXP00000047759	Bet1 golgi vesicular membrane trafficking protein like.	Syntaxin 6; Belongs to the syntaxin family.	0.482
BET1L	vamp3	ENSAMXP00000049700	ENSAMXP00000034847	Bet1 golgi vesicular membrane trafficking protein like.	Vesicle-associated membrane protein 3 (cellubrevin).	0.563
BET1L	vps54	ENSAMXP00000049700	ENSAMXP00000054207	Bet1 golgi vesicular membrane trafficking protein like.	VPS54 subunit of GARP complex.	0.407
BET1L	vti1a	ENSAMXP00000049700	ENSAMXP00000028681	Bet1 golgi vesicular membrane trafficking protein like.	Vesicle transport through interaction with t-SNAREs 1A.	0.574
BET1L	vti1b	ENSAMXP00000049700	ENSAMXP00000054694	Bet1 golgi vesicular membrane trafficking protein like.	Vesicle transport through interaction with t-SNAREs 1B.	0.574
Cltc	ENSAMXP00000054998	ENSAMXP00000002072	ENSAMXP00000054998	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Sorting nexin 1a.	0.503
Cltc	LOC103044300	ENSAMXP00000002072	ENSAMXP00000046787	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Sorting nexin 1b.	0.503
Cltc	Snx2	ENSAMXP00000002072	ENSAMXP00000013036	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Sorting nexin 2.	0.503