(107 nodes) Regulation of MAP kinase activity network (Astyanax mexicanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAMXP00000042872	Uncharacterized protein. (98 aa)
	W5K095_ASTMX	Endoplasmic reticulum to nucleus signaling 1. (1041 aa)
	Htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (467 aa)
	LOC103032217	Dickkopf_N domain-containing protein. (277 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (526 aa)
	axin1	Axin 1. (866 aa)
	ajuba	Ajuba LIM protein. (691 aa)
	NOX4	NADPH oxidase 4. (481 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1105 aa)
	LOC103037777	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (528 aa)
	LOC103041009	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	pdcd10	Programmed cell death 10b. (210 aa)
	W5KGH6_ASTMX	Neurofibromin 1b. (2733 aa)
	LOC103038186	Teneurin transmembrane protein 1. (2718 aa)
	LOC103045335	Si:dkey-175m17.7. (899 aa)
	W5KJZ4_ASTMX	Tumor susceptibility 101b. (358 aa)
	LOC103043145	Dual specificity phosphatase 19b; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (198 aa)
	W5KKX3_ASTMX	Transmembrane protein 130. (278 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (456 aa)
	LOC103024607	Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
	W5KT32_ASTMX	Neurofibromin 1a. (2744 aa)
	W5KVQ2_ASTMX	Interleukin-1 receptor-associated kinase 3. (468 aa)
	LOC103024223	Secreted frizzled-related protein 2 like. (312 aa)
	LOC103030717	Uncharacterized protein. (750 aa)
	W5KZR6_ASTMX	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (343 aa)
	LOC103035431	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1085 aa)
	TENM1	Teneurin transmembrane protein 1. (2670 aa)
	aida	Axin interactor, dorsalization associated. (303 aa)
	LOC103022197	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (202 aa)
	LOC103037941	Progestin and adipoQ receptor family member IIIb. (317 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (605 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
	W5L834_ASTMX	Fibroblast growth factor receptor. (735 aa)
	Lrrk2	Leucine-rich repeat kinase 2. (2537 aa)
	tpd52l1	Tpd52 like 1. (227 aa)
	W5LFM7_ASTMX	Mitogen-activated protein kinase kinase kinase 4. (1473 aa)
	dkk1	Dickkopf WNT signaling pathway inhibitor 1b. (243 aa)
	Sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2015 aa)
	W5LGF4_ASTMX	Endoplasmic reticulum to nucleus signaling 2. (877 aa)
	paqr3	Progestin and adipoQ receptor family member IIIa. (312 aa)
	Spry4	Sprouty homolog 4 (Drosophila). (328 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (284 aa)
	Fzd5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
	LOC103033932	Tribbles pseudokinase 1. (361 aa)
	ENSAMXP00000029221	Uncharacterized protein. (2309 aa)
	sfrp5	Secreted frizzled-related protein 5. (313 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (341 aa)
	ENSAMXP00000030711	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (179 aa)
	il34	Interleukin 34. (210 aa)
	ENSAMXP00000032410	SH2B adaptor protein 3. (520 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (809 aa)
	LOC103036474	Programmed cell death 10a. (210 aa)
	LOC103027348	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (146 aa)
	LOC103044392	Uncharacterized protein. (300 aa)
	gba	Glucosylceramidase. (523 aa)
	LOC103032641	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (526 aa)
	LOC107197829	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (166 aa)
	trib2	Tribbles pseudokinase 2. (344 aa)
	ENSAMXP00000036986	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	LOC103029324	Bone morphogenetic protein 16. (430 aa)
	LOC103033046	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	ENSAMXP00000038137	Dopamine receptor D4b; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103023460	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	epgn	Epithelial mitogen homolog (mouse). (155 aa)
	LOC103037085	3-hydroxy-3-methylglutaryl coenzyme A reductase. (889 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (467 aa)
	LOC111190374	Uncharacterized protein. (256 aa)
	drd4	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	ENSAMXP00000041061	Mitogen-activated protein kinase kinase 7. (511 aa)
	LOC103047496	Protein kinase domain-containing protein. (297 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (880 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (505 aa)
	LOC103026808	Dystrobrevin binding protein 1b. (213 aa)
	ENSAMXP00000042552	Uncharacterized protein. (809 aa)
	Hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (688 aa)
	LOC103038135	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (169 aa)
	lime1	Uncharacterized protein. (473 aa)
	LOC111194997	Interleukin-1. (276 aa)
	LOC103044858	Transforming growth factor, alpha. (186 aa)
	LOC103025686	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	ENSAMXP00000045985	Uncharacterized protein. (904 aa)
	bmp4	TGF_BETA_2 domain-containing protein. (481 aa)
	ENSAMXP00000046425	Interleukin-1. (252 aa)
	Smpd1	Sphingomyelin phosphodiesterase 1, acid lysosomal. (467 aa)
	adipoq	Adiponectin, C1Q and collagen domain containing, b. (309 aa)
	ENSAMXP00000047619	CD40 molecule, TNF receptor superfamily member 5. (353 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (359 aa)
	ENSAMXP00000047894	Endothelin 1. (162 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	ENSAMXP00000048109	Zgc:123278. (190 aa)
	LOC103029481	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC103046764	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSAMXP00000049295	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (231 aa)
	LOC103040019	Tribbles pseudokinase 3. (348 aa)
	ENSAMXP00000049817	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (165 aa)
	sash1	SAM and SH3 domain containing 1a. (1358 aa)
	ENSAMXP00000050565	Dickkopf WNT signaling pathway inhibitor 1a. (277 aa)
	LOC103038583	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (582 aa)
	ENSAMXP00000052402	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (231 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	ENSAMXP00000053072	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (236 aa)
	ENSAMXP00000054040	Uncharacterized protein. (450 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1007 aa)
	ENSAMXP00000055082	Dual specificity phosphatase 19a. (209 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000029221	ENSAMXP00000054040	ENSAMXP00000029221	ENSAMXP00000054040	Uncharacterized protein.	Uncharacterized protein.	0.451
ENSAMXP00000032410	kit	ENSAMXP00000032410	ENSAMXP00000002774	SH2B adaptor protein 3.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.514
ENSAMXP00000036986	LOC103030717	ENSAMXP00000036986	ENSAMXP00000012689	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.413
ENSAMXP00000036986	axin1	ENSAMXP00000036986	ENSAMXP00000003928	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	Axin 1.	0.413
ENSAMXP00000036986	fzd4	ENSAMXP00000036986	ENSAMXP00000003771	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.432
ENSAMXP00000041061	ENSAMXP00000055082	ENSAMXP00000041061	ENSAMXP00000055082	Mitogen-activated protein kinase kinase 7.	Dual specificity phosphatase 19a.	0.567
ENSAMXP00000041061	LOC103043145	ENSAMXP00000041061	ENSAMXP00000008180	Mitogen-activated protein kinase kinase 7.	Dual specificity phosphatase 19b; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.567
ENSAMXP00000041061	LOC103045335	ENSAMXP00000041061	ENSAMXP00000007478	Mitogen-activated protein kinase kinase 7.	Si:dkey-175m17.7.	0.520
ENSAMXP00000041061	map3k13	ENSAMXP00000041061	ENSAMXP00000054096	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase.	0.415
ENSAMXP00000041061	map3k7	ENSAMXP00000041061	ENSAMXP00000014795	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 7.	0.804
ENSAMXP00000042552	LOC103041009	ENSAMXP00000042552	ENSAMXP00000005247	Uncharacterized protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.438
ENSAMXP00000042552	il34	ENSAMXP00000042552	ENSAMXP00000032391	Uncharacterized protein.	Interleukin 34.	0.466
ENSAMXP00000042552	kit	ENSAMXP00000042552	ENSAMXP00000002774	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.661
ENSAMXP00000042872	Hgs	ENSAMXP00000042872	ENSAMXP00000043019	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.631
ENSAMXP00000042872	LOC103044858	ENSAMXP00000042872	ENSAMXP00000044810	Uncharacterized protein.	Transforming growth factor, alpha.	0.611
ENSAMXP00000042872	spry1	ENSAMXP00000042872	ENSAMXP00000047693	Uncharacterized protein.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.646
ENSAMXP00000045985	LOC103041009	ENSAMXP00000045985	ENSAMXP00000005247	Uncharacterized protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.406
ENSAMXP00000045985	W5K095_ASTMX	ENSAMXP00000045985	ENSAMXP00000001005	Uncharacterized protein.	Endoplasmic reticulum to nucleus signaling 1.	0.900
ENSAMXP00000046425	ENSAMXP00000047619	ENSAMXP00000046425	ENSAMXP00000047619	Interleukin-1.	CD40 molecule, TNF receptor superfamily member 5.	0.424
ENSAMXP00000046425	ENSAMXP00000047894	ENSAMXP00000046425	ENSAMXP00000047894	Interleukin-1.	Endothelin 1.	0.410