95 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	f3	Coagulation factor IIIa. (290 aa)
	F3	Coagulation factor III, tissue factor. (293 aa)
	W5K0V1_ASTMX	Si:ch73-380n15.2. (530 aa)
	LOC103030977	Zinc finger CCCH-type containing 12A. (608 aa)
	W5K3M1_ASTMX	Tenascin N. (834 aa)
	Sirt1	Deacetylase sirtuin-type domain-containing protein. (802 aa)
	itgb8	Integrin beta; Belongs to the integrin beta chain family. (790 aa)
	W5KDJ8_ASTMX	Junction plakoglobin b. (709 aa)
	LOC103040838	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	gab1	GRB2-associated binding protein 1. (769 aa)
	Tek	TEK tyrosine kinase, endothelial. (1137 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (637 aa)
	W5KJW0_ASTMX	Complement component 5. (1622 aa)
	LOC103043091	Elastin microfibril interfacer 1a. (1050 aa)
	W5KRB2_ASTMX	Si:ch211-39a7.1. (430 aa)
	W5KRV2_ASTMX	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (757 aa)
	Angptl3	Angiopoietin-like 3. (457 aa)
	LOC103038005	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	LOC103024223	Secreted frizzled-related protein 2 like. (312 aa)
	Jcad	Junctional cadherin 5 associated a. (1554 aa)
	LOC103044564	Receptor (G protein-coupled) activity modifying protein 2. (208 aa)
	W5LBH1_ASTMX	Rap guanine nucleotide exchange factor (GEF) 3. (846 aa)
	LOC103045821	Junction plakoglobin a. (724 aa)
	ecm1	Extracellular matrix protein 1b. (490 aa)
	tgfbr2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
	tbxa2r	Thromboxane A2 receptor. (375 aa)
	LOC103025241	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	W5LSB9_ASTMX	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	W5LTC8_ASTMX	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (523 aa)
	W5LU02_ASTMX	Gremlin. (175 aa)
	ENSAMXP00000027863	Uncharacterized protein. (169 aa)
	cxcr3	Chemokine (C-X-C motif) receptor 3, tandem duplicate 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	adm2	Adrenomedullin 2a. (175 aa)
	Xbp1	X-box binding protein 1. (264 aa)
	LOC111193684	Si:ch211-161c3.6. (114 aa)
	LOC103036816	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa)
	LOC103032524	Uncharacterized protein. (514 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (182 aa)
	vegfd	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (318 aa)
	LOC103041625	Dimethylarginine dimethylaminohydrolase 2. (287 aa)
	Vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (339 aa)
	bmper	BMP binding endothelial regulator. (669 aa)
	LOC103027348	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (146 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (333 aa)
	ENSAMXP00000034094	Insulin-like growth factor 2a. (176 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
	Mtdh	Metadherin a. (511 aa)
	LOC103042873	Midkine a. (145 aa)
	tie1	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1122 aa)
	ENSAMXP00000036546	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (584 aa)
	LOC103038514	LRRCT domain-containing protein. (327 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (823 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSAMXP00000039292	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (401 aa)
	LOC103040845	Nuclear factor, erythroid 2-like 2b. (569 aa)
	ENSAMXP00000040109	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (144 aa)
	LOC103035447	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (265 aa)
	mydgf	Myeloid-derived growth factor. (169 aa)
	LOC103038582	Si:ch211-286o17.1. (326 aa)
	ENSAMXP00000040946	C-C motif chemokine. (133 aa)
	ENSAMXP00000042098	Midkine b. (157 aa)
	sirt6	Sirtuin 6. (396 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1346 aa)
	LOC103038135	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (169 aa)
	LOC103042559	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
	ENSAMXP00000044530	Elastin microfibril interfacer 1b. (992 aa)
	LOC111194997	Interleukin-1. (276 aa)
	ENSAMXP00000044862	Uncharacterized protein. (116 aa)
	ENSAMXP00000044990	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (259 aa)
	LOC103030483	Cholinergic receptor, nicotinic, alpha 7 (neuronal). (506 aa)
	brca1	Uncharacterized protein. (1579 aa)
	LOC111197359	Uncharacterized protein. (492 aa)
	ENSAMXP00000046398	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (270 aa)
	ENSAMXP00000046425	Interleukin-1. (252 aa)
	ENSAMXP00000047619	CD40 molecule, TNF receptor superfamily member 5. (353 aa)
	ENSAMXP00000047691	Uncharacterized protein. (118 aa)
	LOC103029863	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (204 aa)
	LOC103029481	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
	ENSAMXP00000048365	Ninjurin 1. (138 aa)
	LOC103042520	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (259 aa)
	LOC103046764	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	apela	Uncharacterized protein. (55 aa)
	il10	Interleukin 10. (182 aa)
	sash1	SAM and SH3 domain containing 1a. (1358 aa)
	LOC103033738	Uncharacterized protein. (490 aa)
	sp1	Uncharacterized protein. (678 aa)
	LOC103044426	Fibrinogen C-terminal domain-containing protein. (454 aa)
	utp15	UTP15 small subunit processome component. (517 aa)
	ENSAMXP00000053597	Uncharacterized protein. (1310 aa)
	ENSAMXP00000053702	Uncharacterized protein. (283 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (172 aa)
	LOC103041890	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa)
	ENSAMXP00000054408	Si:dkey-206d17.12. (289 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (281 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Angptl3	Tek	ENSAMXP00000010829	ENSAMXP00000007315	Angiopoietin-like 3.	TEK tyrosine kinase, endothelial.	0.409
Angptl3	tie1	ENSAMXP00000010829	ENSAMXP00000036003	Angiopoietin-like 3.	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	0.409
CXCL8	ENSAMXP00000046425	ENSAMXP00000034347	ENSAMXP00000046425	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	Interleukin-1.	0.827
CXCL8	LOC111194997	ENSAMXP00000034347	ENSAMXP00000044776	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	Interleukin-1.	0.827
CXCL8	il10	ENSAMXP00000034347	ENSAMXP00000049622	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	Interleukin 10.	0.484
ENSAMXP00000027863	adm2	ENSAMXP00000027863	ENSAMXP00000029284	Uncharacterized protein.	Adrenomedullin 2a.	0.535
ENSAMXP00000040109	Tek	ENSAMXP00000040109	ENSAMXP00000007315	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	TEK tyrosine kinase, endothelial.	0.457
ENSAMXP00000040109	Vegfc	ENSAMXP00000040109	ENSAMXP00000033799	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.585
ENSAMXP00000040109	kdr	ENSAMXP00000040109	ENSAMXP00000043302	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.716
ENSAMXP00000040109	tie1	ENSAMXP00000040109	ENSAMXP00000036003	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	0.457
ENSAMXP00000040109	vegfd	ENSAMXP00000040109	ENSAMXP00000033003	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.538
ENSAMXP00000040946	il10	ENSAMXP00000040946	ENSAMXP00000049622	C-C motif chemokine.	Interleukin 10.	0.547
ENSAMXP00000044862	adm2	ENSAMXP00000044862	ENSAMXP00000029284	Uncharacterized protein.	Adrenomedullin 2a.	0.535
ENSAMXP00000046398	LOC103035447	ENSAMXP00000046398	ENSAMXP00000040217	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	0.517
ENSAMXP00000046398	Tek	ENSAMXP00000046398	ENSAMXP00000007315	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	TEK tyrosine kinase, endothelial.	0.406
ENSAMXP00000046398	Vegfc	ENSAMXP00000046398	ENSAMXP00000033799	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.408
ENSAMXP00000046398	kdr	ENSAMXP00000046398	ENSAMXP00000043302	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.799
ENSAMXP00000046398	tie1	ENSAMXP00000046398	ENSAMXP00000036003	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.	0.406
ENSAMXP00000046398	vegfd	ENSAMXP00000046398	ENSAMXP00000033003	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.414
ENSAMXP00000046425	CXCL8	ENSAMXP00000046425	ENSAMXP00000034347	Interleukin-1.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.827