21 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	spp2	Secreted phosphoprotein 2. (189 aa)
	lrp6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1618 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Lrrk1	Leucine-rich repeat kinase 1. (1976 aa)
	NOX4	NADPH oxidase 4. (481 aa)
	Lrp5	Low density lipoprotein receptor-related protein 5. (1518 aa)
	Cthrc1	Collagen triple helix repeat containing 1a. (268 aa)
	W5KF41_ASTMX	Leucine-rich repeat containing G protein-coupled receptor 4. (937 aa)
	LOC103024607	Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
	acp5	Tartrate-resistant acid phosphatase type 5. (334 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	ncdn	Neurochondrin. (808 aa)
	ENSAMXP00000030428	Acid phosphatase 5b, tartrate resistant. (396 aa)
	LOC103045871	Collagen triple helix repeat containing 1b. (257 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC103036428	Ephrin-A2b; Belongs to the ephrin family. (206 aa)
	SRC	Tyrosine-protein kinase. (617 aa)
	ENSAMXP00000049817	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (165 aa)
	LOC103038924	Tyrosine-protein kinase. (551 aa)
	ENSAMXP00000051608	Tyrosine-protein kinase. (546 aa)
	ENSAMXP00000052402	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (231 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000030428	acp5	ENSAMXP00000030428	ENSAMXP00000010373	Acid phosphatase 5b, tartrate resistant.	Tartrate-resistant acid phosphatase type 5.	0.903
ENSAMXP00000051608	LOC103038924	ENSAMXP00000051608	ENSAMXP00000050886	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
ENSAMXP00000051608	SRC	ENSAMXP00000051608	ENSAMXP00000046845	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
LOC103024607	tgfb1	ENSAMXP00000010023	ENSAMXP00000002667	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.902
LOC103024607	tgfb3	ENSAMXP00000010023	ENSAMXP00000014857	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.695
LOC103038924	ENSAMXP00000051608	ENSAMXP00000050886	ENSAMXP00000051608	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
LOC103038924	SRC	ENSAMXP00000050886	ENSAMXP00000046845	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
Lrp5	W5KF41_ASTMX	ENSAMXP00000005259	ENSAMXP00000006202	Low density lipoprotein receptor-related protein 5.	Leucine-rich repeat containing G protein-coupled receptor 4.	0.409
Lrp5	lrp6	ENSAMXP00000005259	ENSAMXP00000000719	Low density lipoprotein receptor-related protein 5.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.901
Lrp5	wnt16	ENSAMXP00000005259	ENSAMXP00000040437	Low density lipoprotein receptor-related protein 5.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.804
SRC	ENSAMXP00000051608	ENSAMXP00000046845	ENSAMXP00000051608	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
SRC	LOC103038924	ENSAMXP00000046845	ENSAMXP00000050886	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
W5KF41_ASTMX	Lrp5	ENSAMXP00000006202	ENSAMXP00000005259	Leucine-rich repeat containing G protein-coupled receptor 4.	Low density lipoprotein receptor-related protein 5.	0.409
W5KF41_ASTMX	lrp6	ENSAMXP00000006202	ENSAMXP00000000719	Leucine-rich repeat containing G protein-coupled receptor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.409
acp5	ENSAMXP00000030428	ENSAMXP00000010373	ENSAMXP00000030428	Tartrate-resistant acid phosphatase type 5.	Acid phosphatase 5b, tartrate resistant.	0.903
lrp6	Lrp5	ENSAMXP00000000719	ENSAMXP00000005259	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Low density lipoprotein receptor-related protein 5.	0.901
lrp6	W5KF41_ASTMX	ENSAMXP00000000719	ENSAMXP00000006202	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Leucine-rich repeat containing G protein-coupled receptor 4.	0.409
lrp6	wnt16	ENSAMXP00000000719	ENSAMXP00000040437	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.804
tgfb1	LOC103024607	ENSAMXP00000002667	ENSAMXP00000010023	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.902
tgfb1	tgfb3	ENSAMXP00000002667	ENSAMXP00000014857	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.695