STRINGSTRING
PLN PLN ENSAMXP00000050679 ENSAMXP00000050679 LOC103031087 LOC103031087 ENSAMXP00000051590 ENSAMXP00000051590 ENSAMXP00000047021 ENSAMXP00000047021 LOC103042476 LOC103042476 tgfb2 tgfb2 rbm24 rbm24 ENSAMXP00000053261 ENSAMXP00000053261 LOC103025241 LOC103025241 HAND1 HAND1 LOC103021856 LOC103021856 W5K0L4_ASTMX W5K0L4_ASTMX vwa5b2 vwa5b2 tgfb1 tgfb1 NOX4 NOX4 atg5 atg5 W5KH59_ASTMX W5KH59_ASTMX LOC103047227 LOC103047227 Alpk2 Alpk2 W5KMM6_ASTMX W5KMM6_ASTMX cby1 cby1 Tbx5 Tbx5 LOC103024607 LOC103024607 TBX10 TBX10 Unc45b Unc45b LOC103043088 LOC103043088 LOC103044660 LOC103044660 arid2 arid2 LOC103039408 LOC103039408 mtor mtor LOC103042002 LOC103042002 W5L5P0_ASTMX W5L5P0_ASTMX W5L834_ASTMX W5L834_ASTMX myl7 myl7 LOC103042940 LOC103042940 tsc1 tsc1 LOC103029625 LOC103029625 LOC103026238 LOC103026238 W5LD66_ASTMX W5LD66_ASTMX LOC103022359 LOC103022359 mstn mstn LOC103029394 LOC103029394 W5LMI9_ASTMX W5LMI9_ASTMX LOC103043805 LOC103043805 W5LRA5_ASTMX W5LRA5_ASTMX LOC103044865 LOC103044865 kdm6b kdm6b tbx3 tbx3 bmp4 bmp4 LOC103021519 LOC103021519 ENSAMXP00000046100 ENSAMXP00000046100 mef2a mef2a Tnni1 Tnni1 W5K9M8_ASTMX W5K9M8_ASTMX nkx2-6 nkx2-6 nprl3 nprl3 irx3 irx3 ENSAMXP00000043331 ENSAMXP00000043331 alpk3 alpk3 ENSAMXP00000042910 ENSAMXP00000042910 sirt6 sirt6 ENSAMXP00000042570 ENSAMXP00000042570 LOC103041704 LOC103041704 lrrc39 lrrc39 ENSAMXP00000042035 ENSAMXP00000042035 W5K1H4_ASTMX W5K1H4_ASTMX taz taz zfpm2 zfpm2 LOC103043375 LOC103043375 LOC103021841 LOC103021841 LOC103033399 LOC103033399 opa1 opa1 MYOCD MYOCD ENSAMXP00000037899 ENSAMXP00000037899 sav1 sav1 LOC103029324 LOC103029324 SGCZ SGCZ TNNC1 TNNC1 LOC103028490 LOC103028490 maml1 maml1 LOC103028976 LOC103028976 Mef2c Mef2c ENSAMXP00000035294 ENSAMXP00000035294 mpp5 mpp5 LOC111194303 LOC111194303 ENSAMXP00000033502 ENSAMXP00000033502 ENSAMXP00000033496 ENSAMXP00000033496 zmpste24 zmpste24 ENSAMXP00000033131 ENSAMXP00000033131 Wnt2b Wnt2b fgf8 fgf8 hand2 hand2 LOC107197257 LOC107197257 ENSAMXP00000030497 ENSAMXP00000030497 med1 med1 SRF SRF LOC103028370 LOC103028370 LOC103025318 LOC103025318 ENSAMXP00000028486 ENSAMXP00000028486 LOC103031416 LOC103031416 sgcg sgcg LOC103026375 LOC103026375 LRRC10B LRRC10B W5LU02_ASTMX W5LU02_ASTMX LOC103027015 LOC103027015 LOC103026512 LOC103026512 Lrrc10 Lrrc10 W5LSB9_ASTMX W5LSB9_ASTMX ENSAMXP00000053345 ENSAMXP00000053345 tbx20 tbx20 cemip2 cemip2 acadm acadm isl1 isl1 ENSAMXP00000049034 ENSAMXP00000049034 map2k4 map2k4 LOC107197240 LOC107197240 hey2 hey2 ptcd2 ptcd2 Adprhl1 Adprhl1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ENSAMXP00000050679Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (160 aa)
LOC103031087Divergent protein kinase domain 2Aa. (433 aa)
ENSAMXP00000051590Uncharacterized protein. (180 aa)
ENSAMXP00000047021Ankyrin repeat and SOCS box containing 2a, tandem duplicate 1. (658 aa)
LOC103042476Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
rbm24RNA binding motif protein 24a. (250 aa)
ENSAMXP00000053261annotation not available (35 aa)
LOC103025241Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (359 aa)
HAND1Heart and neural crest derivatives expressed 1. (157 aa)
LOC103021856Bone morphogenetic protein 2a. (405 aa)
W5K0L4_ASTMXMADS-box domain-containing protein. (479 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1328 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
NOX4NADPH oxidase 4. (481 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (276 aa)
W5KH59_ASTMXSarcoglycan, delta (dystrophin-associated glycoprotein). (271 aa)
LOC103047227Uncharacterized protein. (573 aa)
Alpk2Uncharacterized protein. (2658 aa)
W5KMM6_ASTMXTSC complex subunit 1b. (1211 aa)
cby1Chibby homolog 1 (Drosophila). (125 aa)
Tbx5T-box transcription factor 5a. (522 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
TBX10T-box transcription factor 10. (196 aa)
Unc45bUnc-45 myosin chaperone B. (917 aa)
LOC103043088Membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (713 aa)
LOC103044660Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (492 aa)
arid2AT rich interactive domain 2 (ARID, RFX-like). (1711 aa)
LOC103039408Requiem_N domain-containing protein. (342 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2518 aa)
LOC103042002Ankyrin repeat and SOCS box containing 2b. (619 aa)
W5L5P0_ASTMXNebulin-related anchoring protein. (1418 aa)
W5L834_ASTMXFibroblast growth factor receptor. (735 aa)
myl7Myosin, light chain 7, regulatory. (171 aa)
LOC103042940Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (425 aa)
tsc1TSC complex subunit 1a. (1148 aa)
LOC103029625Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
LOC103026238Zinc finger protein, FOG family member 2b. (1118 aa)
W5LD66_ASTMXMothers against decapentaplegic homolog. (573 aa)
LOC103022359Mothers against decapentaplegic homolog. (587 aa)
mstnMyostatin b. (435 aa)
LOC103029394Mothers against decapentaplegic homolog. (544 aa)
W5LMI9_ASTMXT-box transcription factor 1. (417 aa)
LOC103043805Myocyte enhancer factor 2ab. (472 aa)
W5LRA5_ASTMXUncharacterized protein. (157 aa)
LOC103044865Si:ch211-270g19.5. (52 aa)
kdm6bLysine (K)-specific demethylase 6B, a. (1983 aa)
tbx3T-box transcription factor 3a. (706 aa)
bmp4TGF_BETA_2 domain-containing protein. (481 aa)
LOC103021519Troponin C type 1b (slow). (214 aa)
ENSAMXP00000046100Divergent protein kinase domain 2Ab. (323 aa)
mef2aMyocyte enhancer factor 2aa. (517 aa)
Tnni1Troponin I type 1b (skeletal, slow). (170 aa)
W5K9M8_ASTMXUncharacterized protein. (174 aa)
nkx2-6Homeobox domain-containing protein. (294 aa)
nprl3NPR3-like, GATOR1 complex subunit. (655 aa)
irx3Iroquois homeobox 3b. (361 aa)
ENSAMXP00000043331Troponin I4a. (205 aa)
alpk3Uncharacterized protein. (1821 aa)
ENSAMXP00000042910Uncharacterized protein. (248 aa)
sirt6Sirtuin 6. (396 aa)
ENSAMXP00000042570Fermitin family member 2. (641 aa)
LOC103041704Ankyrin repeat and SOCS box containing 2a, tandem duplicate 1. (686 aa)
lrrc39Leucine rich repeat containing 39. (345 aa)
ENSAMXP00000042035Myosin light chain kinase 3. (536 aa)
W5K1H4_ASTMXTroponin I4b, tandem duplicate 1. (178 aa)
tazTafazzin family protein; Belongs to the taffazin family. (277 aa)
zfpm2Zinc finger protein, FOG family member 2a. (1151 aa)
LOC103043375Titin-cap (telethonin). (179 aa)
LOC103021841Islet1, like. (328 aa)
LOC103033399Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (419 aa)
opa1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (982 aa)
MYOCDMyocardin. (999 aa)
ENSAMXP00000037899MADS-box domain-containing protein. (356 aa)
sav1Salvador family WW domain containing protein 1. (405 aa)
LOC103029324Bone morphogenetic protein 16. (430 aa)
SGCZSarcoglycan zeta. (260 aa)
TNNC1Uncharacterized protein. (161 aa)
LOC103028490Lysine (K)-specific demethylase 6B, b. (1798 aa)
maml1Mastermind-like transcriptional coactivator 1. (1070 aa)
LOC103028976Bone morphogenetic protein 2b. (445 aa)
Mef2cMyocyte enhancer factor 2cb. (471 aa)
ENSAMXP00000035294Uncharacterized protein. (1391 aa)
mpp5Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (658 aa)
LOC111194303Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (214 aa)
ENSAMXP00000033502Uncharacterized protein. (387 aa)
ENSAMXP00000033496Cysteine and glycine-rich protein 3 (cardiac LIM protein). (182 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (470 aa)
ENSAMXP00000033131G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
Wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (558 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
hand2Heart and neural crest derivatives expressed 2. (200 aa)
LOC107197257Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
ENSAMXP00000030497Myocyte enhancer factor 2ca. (397 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1801 aa)
SRFSerum response factor. (527 aa)
LOC103028370Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
LOC103025318NK2 homeobox 5. (313 aa)
ENSAMXP00000028486Mothers against decapentaplegic homolog. (493 aa)
LOC103031416D4, zinc and double PHD fingers, family 3. (419 aa)
sgcgSarcoglycan, gamma. (292 aa)
LOC103026375Ankyrin repeat domain 1a (cardiac muscle). (310 aa)
LRRC10BLeucine rich repeat containing 10B. (266 aa)
W5LU02_ASTMXGremlin. (175 aa)
LOC103027015Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (393 aa)
LOC103026512Gremlin 2, DAN family BMP antagonist a. (195 aa)
Lrrc10Leucine rich repeat containing 10. (282 aa)
W5LSB9_ASTMXApelin receptor b; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSAMXP00000053345MH1 domain-containing protein. (187 aa)
tbx20T-box transcription factor 20. (441 aa)
cemip2Cell migration inducing hyaluronidase 2. (1264 aa)
acadmAcyl-CoA dehydrogenase medium chain. (422 aa)
isl1ISL LIM homeobox 1. (332 aa)
ENSAMXP00000049034RRM domain-containing protein. (82 aa)
map2k4Mitogen-activated protein kinase kinase 4a; Belongs to the protein kinase superfamily. (422 aa)
LOC107197240BHLH domain-containing protein. (244 aa)
hey2Hes-related family bHLH transcription factor with YRPW motif 2. (315 aa)
ptcd2Pentatricopeptide repeat domain 2. (370 aa)
Adprhl1ADP-ribosylhydrolase like 1. (301 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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