STRINGSTRING
ENSAMXP00000030591 ENSAMXP00000030591 lrp6 lrp6 sema3a sema3a W5K0L4_ASTMX W5K0L4_ASTMX LOC103033117 LOC103033117 Nfatc4 Nfatc4 tgfb1 tgfb1 W5KA92_ASTMX W5KA92_ASTMX Lrp5 Lrp5 W5KF46_ASTMX W5KF46_ASTMX ctsz ctsz W5KIU0_ASTMX W5KIU0_ASTMX Gbx2 Gbx2 LOC103024607 LOC103024607 W5KU03_ASTMX W5KU03_ASTMX W5KUR6_ASTMX W5KUR6_ASTMX ar ar LOC103024223 LOC103024223 W5L1C8_ASTMX W5L1C8_ASTMX Gdf7 Gdf7 Dag1 Dag1 sars1 sars1 W5LD66_ASTMX W5LD66_ASTMX tmem59l tmem59l LOC103022359 LOC103022359 LOC103029394 LOC103029394 tgfbr2 tgfbr2 nrarp nrarp ENSAMXP00000028486 ENSAMXP00000028486 SRF SRF med1 med1 sfrp5 sfrp5 greb1 greb1 hs6st2 hs6st2 LOC107197257 LOC107197257 ENSAMXP00000033131 ENSAMXP00000033131 LOC103027348 LOC103027348 ctsh ctsh NRARP NRARP nkx3-1 nkx3-1 ENSAMXP00000037031 ENSAMXP00000037031 ENSAMXP00000037899 ENSAMXP00000037899 hhip hhip LOC103035447 LOC103035447 LOC103042847 LOC103042847 ENSAMXP00000041681 ENSAMXP00000041681 ENSAMXP00000042872 ENSAMXP00000042872 gdnf gdnf timeless timeless LOC103038135 LOC103038135 LOC103042559 LOC103042559 lef1 lef1 wnt6 wnt6 spry1 spry1 ENSAMXP00000047894 ENSAMXP00000047894 wt1 wt1 ctnnbip1 ctnnbip1 rspo2 rspo2 LOC103045744 LOC103045744 ENSAMXP00000050201 ENSAMXP00000050201 LOC103037384 LOC103037384 Dlg5 Dlg5 ilk ilk ENSAMXP00000053345 ENSAMXP00000053345 LOC103031663 LOC103031663 ENSAMXP00000054825 ENSAMXP00000054825
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSAMXP00000030591WT1 transcription factor b. (391 aa)
lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1618 aa)
sema3aSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (780 aa)
W5K0L4_ASTMXMADS-box domain-containing protein. (479 aa)
LOC103033117Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (302 aa)
Nfatc4Nuclear factor of activated T cells 4. (812 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
W5KA92_ASTMXDiscs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1806 aa)
Lrp5Low density lipoprotein receptor-related protein 5. (1518 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
W5KIU0_ASTMXMKS transition zone complex subunit 1. (528 aa)
Gbx2Gastrulation brain homeobox 2. (336 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
W5KU03_ASTMXPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (288 aa)
W5KUR6_ASTMXPolycystic kidney disease 1a. (4355 aa)
arAndrogen receptor. (839 aa)
LOC103024223Secreted frizzled-related protein 2 like. (312 aa)
W5L1C8_ASTMXUncharacterized protein. (350 aa)
Gdf7Growth differentiation factor 7. (429 aa)
Dag1Dystroglycan 1. (874 aa)
sars1Seryl-tRNA synthetase. (520 aa)
W5LD66_ASTMXMothers against decapentaplegic homolog. (573 aa)
tmem59lTransmembrane protein 59-like. (339 aa)
LOC103022359Mothers against decapentaplegic homolog. (587 aa)
LOC103029394Mothers against decapentaplegic homolog. (544 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
nrarpNOTCH regulated ankyrin repeat protein a. (112 aa)
ENSAMXP00000028486Mothers against decapentaplegic homolog. (493 aa)
SRFSerum response factor. (527 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1801 aa)
sfrp5Secreted frizzled-related protein 5. (313 aa)
greb1Growth regulating estrogen receptor binding 1. (1821 aa)
hs6st2Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (475 aa)
LOC107197257Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
ENSAMXP00000033131G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
LOC103027348Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (146 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (333 aa)
NRARPNOTCH regulated ankyrin repeat protein b. (107 aa)
nkx3-1NK3 homeobox 1. (202 aa)
ENSAMXP00000037031MKS transition zone complex subunit 1. (534 aa)
ENSAMXP00000037899MADS-box domain-containing protein. (356 aa)
hhipHedgehog interacting protein. (693 aa)
LOC103035447Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (265 aa)
LOC103042847Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (170 aa)
ENSAMXP00000041681Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (273 aa)
ENSAMXP00000042872Uncharacterized protein. (98 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (245 aa)
timelessTimeless circadian clock. (1256 aa)
LOC103038135Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (169 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
lef1Lymphoid enhancer-binding factor 1. (384 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (359 aa)
ENSAMXP00000047894Endothelin 1. (162 aa)
wt1WT1 transcription factor a. (415 aa)
ctnnbip1Catenin, beta interacting protein 1. (81 aa)
rspo2R-spondin 2. (244 aa)
LOC103045744Colony stimulating factor 1a (macrophage). (531 aa)
ENSAMXP00000050201Pept_C1 domain-containing protein. (228 aa)
LOC103037384Uncharacterized protein. (170 aa)
Dlg5Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1945 aa)
ilkIntegrin-linked kinase. (452 aa)
ENSAMXP00000053345MH1 domain-containing protein. (187 aa)
LOC103031663Transcription factor 21. (182 aa)
ENSAMXP00000054825Colony stimulating factor 1b (macrophage). (298 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.