(62 nodes) Heart contraction network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103025318	NK2 homeobox 5. (313 aa)
	LOC103047490	Myosin light chain 2. (170 aa)
	ENSAMXP00000049261	Potassium voltage-gated channel, Isk-related family, member 4. (172 aa)
	LOC103046819	Sodium channel, voltage-gated, type I, beta b. (253 aa)
	scn2b	Sodium channel, voltage-gated, type II, beta. (216 aa)
	kcnq1	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (662 aa)
	LOC103021519	Troponin C type 1b (slow). (214 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (720 aa)
	Tnni1	Troponin I type 1b (skeletal, slow). (170 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (223 aa)
	nkx2-6	Homeobox domain-containing protein. (294 aa)
	LOC103022780	Uncharacterized protein. (217 aa)
	ENSAMXP00000043331	Troponin I4a. (205 aa)
	lrrc39	Leucine rich repeat containing 39. (345 aa)
	W5K1H4_ASTMX	Troponin I4b, tandem duplicate 1. (178 aa)
	ENSAMXP00000041720	Uncharacterized protein. (156 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (277 aa)
	nup155	Nucleoporin 155. (1391 aa)
	LOC103043375	Titin-cap (telethonin). (179 aa)
	ENSAMXP00000040109	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (144 aa)
	ENSAMXP00000039450	Uncharacterized protein. (120 aa)
	ENSAMXP00000038960	Uncharacterized protein. (124 aa)
	LOC103035007	Troponin I type 2a (skeletal, fast), tandem duplicate 1. (193 aa)
	ccm2	CCM2 scaffold protein. (456 aa)
	SGCZ	Sarcoglycan zeta. (260 aa)
	TNNC1	Uncharacterized protein. (161 aa)
	LOC103028784	Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (734 aa)
	LOC103030419	Myosin, light chain 13. (185 aa)
	ENSAMXP00000035309	RNA binding fox-1 homolog 1. (367 aa)
	LOC103029052	Sodium channel, voltage-gated, type I, beta a. (227 aa)
	smyd2	SET and MYND domain containing 2a. (433 aa)
	ENSAMXP00000033496	Cysteine and glycine-rich protein 3 (cardiac LIM protein). (182 aa)
	ENSAMXP00000032309	Troponin I, skeletal, slow d. (186 aa)
	washc5	WASH complex subunit 5. (1159 aa)
	hand2	Heart and neural crest derivatives expressed 2. (200 aa)
	bves	Blood vessel epicardial substance. (359 aa)
	W5K8T0_ASTMX	Troponin I, skeletal, slow c. (215 aa)
	Strip1	Striatin interacting protein 1. (817 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (276 aa)
	LOC103040838	Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	W5KH59_ASTMX	Sarcoglycan, delta (dystrophin-associated glycoprotein). (271 aa)
	Alpk2	Uncharacterized protein. (2658 aa)
	LOC103039046	Myosin, light chain 10, regulatory. (219 aa)
	W5KY93_ASTMX	Uncharacterized protein. (440 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2518 aa)
	myl7	Myosin, light chain 7, regulatory. (171 aa)
	W5LCR2_ASTMX	Troponin I2, fast skeletal type. (170 aa)
	W5LCS6_ASTMX	Troponin I type 2a (skeletal, fast), tandem duplicate 4. (172 aa)
	LOC103031423	DND microRNA-mediated repression inhibitor 1. (405 aa)
	krit1	KRIT1 ankyrin repeat containing. (741 aa)
	LOC103022042	Troponin I type 2b (skeletal, fast), tandem duplicate 1. (176 aa)
	W5LRA5_ASTMX	Uncharacterized protein. (157 aa)
	W5LSN2_ASTMX	Uncharacterized protein. (164 aa)
	Gper1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (405 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (119 aa)
	sgcg	Sarcoglycan, gamma. (292 aa)
	LOC103034677	Zgc:163073. (207 aa)
	LOC103034366	Troponin I type 2a (skeletal, fast), tandem duplicate 4. (176 aa)
	LOC103044021	Myosin, light chain 2b, regulatory, cardiac, slow. (168 aa)
	scn4b	Sodium channel, voltage-gated, type IV, beta a. (233 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (312 aa)
	ENSAMXP00000051590	Uncharacterized protein. (180 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000032309	ENSAMXP00000039450	ENSAMXP00000032309	ENSAMXP00000039450	Troponin I, skeletal, slow d.	Uncharacterized protein.	0.409
ENSAMXP00000032309	ENSAMXP00000041720	ENSAMXP00000032309	ENSAMXP00000041720	Troponin I, skeletal, slow d.	Uncharacterized protein.	0.439
ENSAMXP00000032309	ENSAMXP00000043331	ENSAMXP00000032309	ENSAMXP00000043331	Troponin I, skeletal, slow d.	Troponin I4a.	0.431
ENSAMXP00000032309	LOC103021519	ENSAMXP00000032309	ENSAMXP00000046189	Troponin I, skeletal, slow d.	Troponin C type 1b (slow).	0.611
ENSAMXP00000032309	LOC103022780	ENSAMXP00000032309	ENSAMXP00000044029	Troponin I, skeletal, slow d.	Uncharacterized protein.	0.439
ENSAMXP00000032309	LOC103030419	ENSAMXP00000032309	ENSAMXP00000035692	Troponin I, skeletal, slow d.	Myosin, light chain 13.	0.505
ENSAMXP00000032309	LOC103034677	ENSAMXP00000032309	ENSAMXP00000028429	Troponin I, skeletal, slow d.	Zgc:163073.	0.505
ENSAMXP00000032309	LOC103039046	ENSAMXP00000032309	ENSAMXP00000009051	Troponin I, skeletal, slow d.	Myosin, light chain 10, regulatory.	0.439
ENSAMXP00000032309	LOC103044021	ENSAMXP00000032309	ENSAMXP00000054127	Troponin I, skeletal, slow d.	Myosin, light chain 2b, regulatory, cardiac, slow.	0.439
ENSAMXP00000032309	LOC103047490	ENSAMXP00000032309	ENSAMXP00000049703	Troponin I, skeletal, slow d.	Myosin light chain 2.	0.439
ENSAMXP00000032309	TNNC1	ENSAMXP00000032309	ENSAMXP00000036526	Troponin I, skeletal, slow d.	Uncharacterized protein.	0.611
ENSAMXP00000032309	W5K1H4_ASTMX	ENSAMXP00000032309	ENSAMXP00000042011	Troponin I, skeletal, slow d.	Troponin I4b, tandem duplicate 1.	0.409
ENSAMXP00000032309	W5LRA5_ASTMX	ENSAMXP00000032309	ENSAMXP00000025410	Troponin I, skeletal, slow d.	Uncharacterized protein.	0.611
ENSAMXP00000032309	W5LSN2_ASTMX	ENSAMXP00000032309	ENSAMXP00000025987	Troponin I, skeletal, slow d.	Uncharacterized protein.	0.505
ENSAMXP00000032309	myl7	ENSAMXP00000032309	ENSAMXP00000016015	Troponin I, skeletal, slow d.	Myosin, light chain 7, regulatory.	0.522
ENSAMXP00000033496	ENSAMXP00000041720	ENSAMXP00000033496	ENSAMXP00000041720	Cysteine and glycine-rich protein 3 (cardiac LIM protein).	Uncharacterized protein.	0.419
ENSAMXP00000033496	ENSAMXP00000043331	ENSAMXP00000033496	ENSAMXP00000043331	Cysteine and glycine-rich protein 3 (cardiac LIM protein).	Troponin I4a.	0.450
ENSAMXP00000033496	ENSAMXP00000051590	ENSAMXP00000033496	ENSAMXP00000051590	Cysteine and glycine-rich protein 3 (cardiac LIM protein).	Uncharacterized protein.	0.450
ENSAMXP00000033496	LOC103021519	ENSAMXP00000033496	ENSAMXP00000046189	Cysteine and glycine-rich protein 3 (cardiac LIM protein).	Troponin C type 1b (slow).	0.500
ENSAMXP00000033496	LOC103022780	ENSAMXP00000033496	ENSAMXP00000044029	Cysteine and glycine-rich protein 3 (cardiac LIM protein).	Uncharacterized protein.	0.419