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lrp6 lrp6 LOC103032053 LOC103032053 LOC103043510 LOC103043510 ENSAMXP00000029247 ENSAMXP00000029247 ENSAMXP00000029017 ENSAMXP00000029017 LOC103030903 LOC103030903 LOC103036475 LOC103036475 sfrp1 sfrp1 wnt9b wnt9b Fzd5 Fzd5 W5LU60_ASTMX W5LU60_ASTMX LOC103027133 LOC103027133 W5LSI7_ASTMX W5LSI7_ASTMX FZD7 FZD7 kctd15 kctd15 LOC103046908 LOC103046908 bcl9l bcl9l LOC103045821 LOC103045821 dkk1 dkk1 LOC103029625 LOC103029625 W5L9B2_ASTMX W5L9B2_ASTMX Fzd10 Fzd10 LOC103044722 LOC103044722 W5L3R0_ASTMX W5L3R0_ASTMX LOC103047839 LOC103047839 LOC103035729 LOC103035729 dvl2 dvl2 bcl9 bcl9 LOC103024223 LOC103024223 LOC103021666 LOC103021666 LOC103022398 LOC103022398 W5KJA8_ASTMX W5KJA8_ASTMX W5KDJ8_ASTMX W5KDJ8_ASTMX LOC103022374 LOC103022374 Lrp5 Lrp5 HESX1 HESX1 fzd4 fzd4 LOC103034575 LOC103034575 LOC103032217 LOC103032217 W5K3B2_ASTMX W5K3B2_ASTMX LOC103043104 LOC103043104 reck reck fzd3 fzd3 Wnt10a Wnt10a frzb frzb wnt7a wnt7a Eda Eda LOC107197257 LOC107197257 Wnt2b Wnt2b ENSAMXP00000033131 ENSAMXP00000033131 ENSAMXP00000034556 ENSAMXP00000034556 LOC103042896 LOC103042896 Wnt4 Wnt4 ENSAMXP00000036986 ENSAMXP00000036986 ENSAMXP00000037825 ENSAMXP00000037825 LOC103041046 LOC103041046 LOC103023460 LOC103023460 ENSAMXP00000038907 ENSAMXP00000038907 ENSAMXP00000040119 ENSAMXP00000040119 wnt16 wnt16 Fzd6 Fzd6 ENSAMXP00000041224 ENSAMXP00000041224 ENSAMXP00000042370 ENSAMXP00000042370 LOC103038145 LOC103038145 sfrp2 sfrp2 LOC103036102 LOC103036102 SDC1 SDC1 sostdc1 sostdc1 wnt8b wnt8b wnt5a wnt5a lef1 lef1 tcf7l2 tcf7l2 wnt6 wnt6 LOC103026929 LOC103026929 LOC103047026 LOC103047026 wnt10b wnt10b ENSAMXP00000047894 ENSAMXP00000047894 rspo2 rspo2 Wnt1 Wnt1 scyl2 scyl2 ctnnb1 ctnnb1 ENSAMXP00000050565 ENSAMXP00000050565 wnt7b wnt7b ENSAMXP00000050856 ENSAMXP00000050856 LOC103046093 LOC103046093 Fzd2 Fzd2 plpp3 plpp3 sfrp5 sfrp5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1618 aa)
LOC103032053Potassium channel tetramerization domain containing 15a. (266 aa)
LOC103043510G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
ENSAMXP00000029247Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ENSAMXP00000029017Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (203 aa)
LOC103030903DIX domain containing 1b. (695 aa)
LOC103036475PHD-type domain-containing protein. (581 aa)
sfrp1Secreted frizzled-related protein 1a. (306 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
Fzd5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
W5LU60_ASTMXFrizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
LOC103027133Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
W5LSI7_ASTMXFrizzled class receptor 9a; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
kctd15Potassium channel tetramerization domain containing 15. (265 aa)
LOC103046908Secreted frizzled-related protein 1b. (297 aa)
bcl9lBcl9 like. (1520 aa)
LOC103045821Junction plakoglobin a. (724 aa)
dkk1Dickkopf WNT signaling pathway inhibitor 1b. (243 aa)
LOC103029625Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
W5L9B2_ASTMXTranscription factor 7. (442 aa)
Fzd10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (527 aa)
LOC103044722Sizzled. (284 aa)
W5L3R0_ASTMXDishevelled segment polarity protein 3b. (662 aa)
LOC103047839Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (460 aa)
LOC103035729Dishevelled segment polarity protein 1a. (731 aa)
dvl2Dishevelled segment polarity protein 2. (752 aa)
bcl9BCL9 transcription coactivator. (1594 aa)
LOC103024223Secreted frizzled-related protein 2 like. (312 aa)
LOC103021666Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LOC103022398Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
W5KJA8_ASTMXProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (402 aa)
W5KDJ8_ASTMXJunction plakoglobin b. (709 aa)
LOC103022374Transcription factor 7 like 1b. (583 aa)
Lrp5Low density lipoprotein receptor-related protein 5. (1518 aa)
HESX1HESX homeobox 1. (151 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (526 aa)
LOC103034575Catenin, beta 2. (779 aa)
LOC103032217Dickkopf_N domain-containing protein. (277 aa)
W5K3B2_ASTMXUncharacterized protein. (289 aa)
LOC103043104Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (444 aa)
reckReversion-inducing-cysteine-rich protein with kazal motifs. (959 aa)
fzd3Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (689 aa)
Wnt10aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
frzbFrizzled related protein. (323 aa)
wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
EdaEctodysplasin A; Belongs to the tumor necrosis factor family. (449 aa)
LOC107197257Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (451 aa)
Wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (558 aa)
ENSAMXP00000033131G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (475 aa)
ENSAMXP00000034556Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
LOC103042896Dishevelled segment polarity protein 3a. (676 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSAMXP00000036986Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
ENSAMXP00000037825Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC103041046Sclerostin domain containing 1b. (187 aa)
LOC103023460Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
ENSAMXP00000038907DIX domain containing 1a. (402 aa)
ENSAMXP00000040119Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (404 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
Fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (704 aa)
ENSAMXP00000041224Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (295 aa)
ENSAMXP00000042370Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LOC103038145TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (362 aa)
sfrp2Secreted frizzled-related protein 2. (294 aa)
LOC103036102Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (370 aa)
sostdc1Sclerostin domain containing 1a. (227 aa)
wnt8bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
lef1Lymphoid enhancer-binding factor 1. (384 aa)
tcf7l2Transcription factor 7 like 2. (630 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LOC103026929Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
LOC103047026acidPPc domain-containing protein. (309 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (427 aa)
ENSAMXP00000047894Endothelin 1. (162 aa)
rspo2R-spondin 2. (244 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (403 aa)
scyl2SCY1 like pseudokinase 2. (931 aa)
ctnnb1Catenin (cadherin-associated protein), beta 1. (790 aa)
ENSAMXP00000050565Dickkopf WNT signaling pathway inhibitor 1a. (277 aa)
wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ENSAMXP00000050856FZ domain-containing protein. (90 aa)
LOC103046093Dishevelled segment polarity protein 1b. (726 aa)
Fzd2Frizzled class receptor 2. (240 aa)
plpp3Phospholipid phosphatase 3. (313 aa)
sfrp5Secreted frizzled-related protein 5. (313 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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