(20 nodes) Wnt signaling pathway, planar cell polarity pathway network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5L3R0_ASTMX	Dishevelled segment polarity protein 3b. (662 aa)
	sfrp5	Secreted frizzled-related protein 5. (313 aa)
	wnt7a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa)
	LOC103045871	Collagen triple helix repeat containing 1b. (257 aa)
	LOC103042896	Dishevelled segment polarity protein 3a. (676 aa)
	vangl2	Vang-like protein. (524 aa)
	ryk	Receptor like tyrosine kinase. (627 aa)
	LOC103036576	Vang-like protein. (536 aa)
	ENSAMXP00000041588	Protein kinase domain-containing protein. (117 aa)
	ENSAMXP00000042370	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	LOC103026929	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	adgra3	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1394 aa)
	VANGL1	Vang-like protein. (529 aa)
	Cthrc1	Collagen triple helix repeat containing 1a. (268 aa)
	LOC103024223	Secreted frizzled-related protein 2 like. (312 aa)
	LOC103046093	Dishevelled segment polarity protein 1b. (726 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	dvl2	Dishevelled segment polarity protein 2. (752 aa)
	LOC103035729	Dishevelled segment polarity protein 1a. (731 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000041588	LOC103036576	ENSAMXP00000041588	ENSAMXP00000041152	Protein kinase domain-containing protein.	Vang-like protein.	0.453
ENSAMXP00000041588	VANGL1	ENSAMXP00000041588	ENSAMXP00000005398	Protein kinase domain-containing protein.	Vang-like protein.	0.453
ENSAMXP00000041588	W5L3R0_ASTMX	ENSAMXP00000041588	ENSAMXP00000014472	Protein kinase domain-containing protein.	Dishevelled segment polarity protein 3b.	0.407
ENSAMXP00000041588	dvl2	ENSAMXP00000041588	ENSAMXP00000013503	Protein kinase domain-containing protein.	Dishevelled segment polarity protein 2.	0.402
ENSAMXP00000041588	vangl2	ENSAMXP00000041588	ENSAMXP00000035179	Protein kinase domain-containing protein.	Vang-like protein.	0.467
ENSAMXP00000042370	LOC103024223	ENSAMXP00000042370	ENSAMXP00000011888	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2 like.	0.830
ENSAMXP00000042370	LOC103035729	ENSAMXP00000042370	ENSAMXP00000013711	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dishevelled segment polarity protein 1a.	0.446
ENSAMXP00000042370	LOC103042896	ENSAMXP00000042370	ENSAMXP00000034903	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dishevelled segment polarity protein 3a.	0.446
ENSAMXP00000042370	LOC103046093	ENSAMXP00000042370	ENSAMXP00000051676	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dishevelled segment polarity protein 1b.	0.446
ENSAMXP00000042370	W5L3R0_ASTMX	ENSAMXP00000042370	ENSAMXP00000014472	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dishevelled segment polarity protein 3b.	0.446
ENSAMXP00000042370	dvl2	ENSAMXP00000042370	ENSAMXP00000013503	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dishevelled segment polarity protein 2.	0.446
ENSAMXP00000042370	ryk	ENSAMXP00000042370	ENSAMXP00000037893	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.687
ENSAMXP00000042370	sfrp5	ENSAMXP00000042370	ENSAMXP00000030242	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 5.	0.817
LOC103024223	ENSAMXP00000042370	ENSAMXP00000011888	ENSAMXP00000042370	Secreted frizzled-related protein 2 like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.830
LOC103024223	LOC103026929	ENSAMXP00000011888	ENSAMXP00000046597	Secreted frizzled-related protein 2 like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.830
LOC103024223	LOC103035729	ENSAMXP00000011888	ENSAMXP00000013711	Secreted frizzled-related protein 2 like.	Dishevelled segment polarity protein 1a.	0.483
LOC103024223	LOC103036576	ENSAMXP00000011888	ENSAMXP00000041152	Secreted frizzled-related protein 2 like.	Vang-like protein.	0.431
LOC103024223	LOC103042896	ENSAMXP00000011888	ENSAMXP00000034903	Secreted frizzled-related protein 2 like.	Dishevelled segment polarity protein 3a.	0.483
LOC103024223	LOC103046093	ENSAMXP00000011888	ENSAMXP00000051676	Secreted frizzled-related protein 2 like.	Dishevelled segment polarity protein 1b.	0.483
LOC103024223	VANGL1	ENSAMXP00000011888	ENSAMXP00000005398	Secreted frizzled-related protein 2 like.	Vang-like protein.	0.431