(20 nodes) Hematopoietic stem cell differentiation network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rspo1	R-spondin 1. (266 aa)
	W5K0L4_ASTMX	MADS-box domain-containing protein. (479 aa)
	ak2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (123 aa)
	LOC103034623	Notch receptor 1a. (2450 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
	W5LCK6_ASTMX	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1068 aa)
	LOC103039499	Uncharacterized protein. (686 aa)
	SRF	Serum response factor. (527 aa)
	LOC103022914	FEV transcription factor, ETS family member. (218 aa)
	ENSAMXP00000032410	SH2B adaptor protein 3. (520 aa)
	meox1	Mesenchyme homeobox 1. (253 aa)
	ENSAMXP00000037899	MADS-box domain-containing protein. (356 aa)
	Mib1	Mindbomb E3 ubiquitin protein ligase 1. (1027 aa)
	ENSAMXP00000048151	UFM1-specific ligase 1. (687 aa)
	Dll3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (708 aa)
	LOC103025197	Notch receptor 1b. (2477 aa)
	Tal1	T-cell acute lymphocytic leukemia 1. (371 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dll3	LOC103025197	ENSAMXP00000050702	ENSAMXP00000051793	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1b.	0.976
Dll3	LOC103034623	ENSAMXP00000050702	ENSAMXP00000015021	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1a.	0.976
Dll3	Mib1	ENSAMXP00000050702	ENSAMXP00000037923	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.588
Dll3	dll1	ENSAMXP00000050702	ENSAMXP00000015776	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
LOC103025197	Dll3	ENSAMXP00000051793	ENSAMXP00000050702	Notch receptor 1b.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.976
LOC103025197	dll1	ENSAMXP00000051793	ENSAMXP00000015776	Notch receptor 1b.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.976
LOC103034623	Dll3	ENSAMXP00000015021	ENSAMXP00000050702	Notch receptor 1a.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.976
LOC103034623	dll1	ENSAMXP00000015021	ENSAMXP00000015776	Notch receptor 1a.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.976
LOC103039499	Tal1	ENSAMXP00000022186	ENSAMXP00000054373	Uncharacterized protein.	T-cell acute lymphocytic leukemia 1.	0.493
Mib1	Dll3	ENSAMXP00000037923	ENSAMXP00000050702	Mindbomb E3 ubiquitin protein ligase 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.588
Mib1	dll1	ENSAMXP00000037923	ENSAMXP00000015776	Mindbomb E3 ubiquitin protein ligase 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.678
Tal1	LOC103039499	ENSAMXP00000054373	ENSAMXP00000022186	T-cell acute lymphocytic leukemia 1.	Uncharacterized protein.	0.493
dll1	Dll3	ENSAMXP00000015776	ENSAMXP00000050702	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
dll1	LOC103025197	ENSAMXP00000015776	ENSAMXP00000051793	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1b.	0.976
dll1	LOC103034623	ENSAMXP00000015776	ENSAMXP00000015021	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1a.	0.976
dll1	Mib1	ENSAMXP00000015776	ENSAMXP00000037923	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.678
ercc2	xrcc5	ENSAMXP00000009302	ENSAMXP00000003388	Excision repair cross-complementation group 2.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.579
xrcc5	ercc2	ENSAMXP00000003388	ENSAMXP00000009302	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	Excision repair cross-complementation group 2.	0.579