STRINGSTRING
ENSAMXP00000044822 ENSAMXP00000044822 ENSAMXP00000044564 ENSAMXP00000044564 LOC103042559 LOC103042559 sirt6 sirt6 ENSAMXP00000042552 ENSAMXP00000042552 LOC103043941 LOC103043941 Sox18 Sox18 kdm1a kdm1a Vegfc Vegfc kdf1 kdf1 PTPRC PTPRC ENSAMXP00000032607 ENSAMXP00000032607 ENSAMXP00000031911 ENSAMXP00000031911 ENSAMXP00000030950 ENSAMXP00000030950 fgf4 fgf4 LOC111193684 LOC111193684 LOC103046695 LOC103046695 tgfbr2 tgfbr2 LOC103021321 LOC103021321 dgcr8 dgcr8 fermt1 fermt1 W5KT32_ASTMX W5KT32_ASTMX LOC103024607 LOC103024607 W5KQH5_ASTMX W5KQH5_ASTMX W5KN49_ASTMX W5KN49_ASTMX W5KGH6_ASTMX W5KGH6_ASTMX W5KF46_ASTMX W5KF46_ASTMX pdcd2 pdcd2 W5K3J1_ASTMX W5K3J1_ASTMX W5K4D5_ASTMX W5K4D5_ASTMX tgfb1 tgfb1 nf2 nf2 cdkn2c cdkn2c ENSAMXP00000053702 ENSAMXP00000053702 atxn1l atxn1l ago2 ago2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSAMXP00000044822ArgoN domain-containing protein. (84 aa)
ENSAMXP00000044564ArgoN domain-containing protein. (62 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
sirt6Sirtuin 6. (396 aa)
ENSAMXP00000042552Uncharacterized protein. (809 aa)
LOC103043941H6 family homeobox 2. (276 aa)
Sox18SRY-box transcription factor 18. (470 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (849 aa)
VegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (339 aa)
kdf1Keratinocyte differentiation factor 1a. (434 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (809 aa)
ENSAMXP00000032607Eukaryotic translation initiation factor 2-alpha kinase 2. (599 aa)
ENSAMXP00000031911Uncharacterized protein. (212 aa)
ENSAMXP00000030950ArgoN domain-containing protein. (71 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
LOC111193684Si:ch211-161c3.6. (114 aa)
LOC103046695Neurofibromin 2b (merlin). (587 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
LOC103021321SRY-box transcription factor 17. (428 aa)
dgcr8DGCR8 microprocessor complex subunit. (785 aa)
fermt1Fermitin family member 1. (662 aa)
W5KT32_ASTMXNeurofibromin 1a. (2744 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
W5KQH5_ASTMXArgonaute RISC catalytic component 3b; Belongs to the argonaute family. (776 aa)
W5KN49_ASTMXUncharacterized protein; Belongs to the heparin-binding growth factors family. (67 aa)
W5KGH6_ASTMXNeurofibromin 1b. (2733 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
pdcd2Programmed cell death 2. (356 aa)
W5K3J1_ASTMXArgonaute RISC component 1; Belongs to the argonaute family. (703 aa)
W5K4D5_ASTMXArgonaute RISC catalytic component 3a; Belongs to the argonaute family. (774 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
nf2Neurofibromin 2a (merlin). (591 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (174 aa)
ENSAMXP00000053702Uncharacterized protein. (283 aa)
atxn1lAtaxin 1-like. (870 aa)
ago2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (872 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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