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kdm1a kdm1a Vegfc Vegfc kdf1 kdf1 PTPRC PTPRC ENSAMXP00000032607 ENSAMXP00000032607 ENSAMXP00000031911 ENSAMXP00000031911 ENSAMXP00000030950 ENSAMXP00000030950 fgf4 fgf4 LOC111193684 LOC111193684 LOC103046695 LOC103046695 tgfbr2 tgfbr2 LOC103021321 LOC103021321 dgcr8 dgcr8 fermt1 fermt1 W5KT32_ASTMX W5KT32_ASTMX LOC103024607 LOC103024607 W5KQH5_ASTMX W5KQH5_ASTMX W5KN49_ASTMX W5KN49_ASTMX W5KGH6_ASTMX W5KGH6_ASTMX W5KF46_ASTMX W5KF46_ASTMX pdcd2 pdcd2 tgfb1 tgfb1 W5K4D5_ASTMX W5K4D5_ASTMX W5K3J1_ASTMX W5K3J1_ASTMX cdkn2c cdkn2c ENSAMXP00000053702 ENSAMXP00000053702 ago2 ago2 ENSAMXP00000044564 ENSAMXP00000044564 ENSAMXP00000042552 ENSAMXP00000042552 sirt6 sirt6 ENSAMXP00000044822 ENSAMXP00000044822 atxn1l atxn1l nf2 nf2 LOC103042559 LOC103042559 LOC103043941 LOC103043941 Sox18 Sox18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (849 aa)
VegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (339 aa)
kdf1Keratinocyte differentiation factor 1a. (434 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (809 aa)
ENSAMXP00000032607Eukaryotic translation initiation factor 2-alpha kinase 2. (599 aa)
ENSAMXP00000031911Uncharacterized protein. (212 aa)
ENSAMXP00000030950ArgoN domain-containing protein. (71 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
LOC111193684Si:ch211-161c3.6. (114 aa)
LOC103046695Neurofibromin 2b (merlin). (587 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
LOC103021321SRY-box transcription factor 17. (428 aa)
dgcr8DGCR8 microprocessor complex subunit. (785 aa)
fermt1Fermitin family member 1. (662 aa)
W5KT32_ASTMXNeurofibromin 1a. (2744 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
W5KQH5_ASTMXArgonaute RISC catalytic component 3b; Belongs to the argonaute family. (776 aa)
W5KN49_ASTMXUncharacterized protein; Belongs to the heparin-binding growth factors family. (67 aa)
W5KGH6_ASTMXNeurofibromin 1b. (2733 aa)
W5KF46_ASTMXTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (561 aa)
pdcd2Programmed cell death 2. (356 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
W5K4D5_ASTMXArgonaute RISC catalytic component 3a; Belongs to the argonaute family. (774 aa)
W5K3J1_ASTMXArgonaute RISC component 1; Belongs to the argonaute family. (703 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (174 aa)
ENSAMXP00000053702Uncharacterized protein. (283 aa)
ago2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (872 aa)
ENSAMXP00000044564ArgoN domain-containing protein. (62 aa)
ENSAMXP00000042552Uncharacterized protein. (809 aa)
sirt6Sirtuin 6. (396 aa)
ENSAMXP00000044822ArgoN domain-containing protein. (84 aa)
atxn1lAtaxin 1-like. (870 aa)
nf2Neurofibromin 2a (merlin). (591 aa)
LOC103042559Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
LOC103043941H6 family homeobox 2. (276 aa)
Sox18SRY-box transcription factor 18. (470 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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