(21 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Astyanax mexicanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	LOC103046057	MCL1 apoptosis regulator, BCL2 family member b. (244 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	bag3	BCL2 associated athanogene 3. (527 aa)
	Bax	BCL2 associated X, apoptosis regulator a. (190 aa)
	W5KF74_ASTMX	BCL2 family apoptosis regulator BOK b. (228 aa)
	W5KGH6_ASTMX	Neurofibromin 1b. (2733 aa)
	fadd	Fas (tnfrsf6)-associated via death domain. (190 aa)
	LOC103047816	Zgc:153993. (204 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	W5KT32_ASTMX	Neurofibromin 1a. (2744 aa)
	LOC103035823	BCL2 like 10. (176 aa)
	LOC111197410	Uncharacterized protein. (242 aa)
	LOC103032659	BCL2 associated agonist of cell death b. (179 aa)
	bok	BCL2 family apoptosis regulator BOK a. (215 aa)
	LOC103043574	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (420 aa)
	ENSAMXP00000038752	Uncharacterized protein. (207 aa)
	LOC103042396	Uncharacterized protein. (181 aa)
	Bcl2l1	BCL2 like 1. (239 aa)
	LOC103032471	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (429 aa)
	bcl2l11	Bclx_interact domain-containing protein. (203 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (508 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bax	Bcl2l1	ENSAMXP00000005311	ENSAMXP00000041865	BCL2 associated X, apoptosis regulator a.	BCL2 like 1.	0.999
Bax	ENSAMXP00000038752	ENSAMXP00000005311	ENSAMXP00000038752	BCL2 associated X, apoptosis regulator a.	Uncharacterized protein.	0.869
Bax	LOC103032659	ENSAMXP00000005311	ENSAMXP00000029182	BCL2 associated X, apoptosis regulator a.	BCL2 associated agonist of cell death b.	0.774
Bax	LOC103046057	ENSAMXP00000005311	ENSAMXP00000048964	BCL2 associated X, apoptosis regulator a.	MCL1 apoptosis regulator, BCL2 family member b.	0.869
Bax	LOC103047816	ENSAMXP00000005311	ENSAMXP00000007605	BCL2 associated X, apoptosis regulator a.	Zgc:153993.	0.904
Bax	LOC111197410	ENSAMXP00000005311	ENSAMXP00000028473	BCL2 associated X, apoptosis regulator a.	Uncharacterized protein.	0.869
Bax	bcl2l11	ENSAMXP00000005311	ENSAMXP00000046456	BCL2 associated X, apoptosis regulator a.	Bclx_interact domain-containing protein.	0.991
Bcl2l1	Bax	ENSAMXP00000041865	ENSAMXP00000005311	BCL2 like 1.	BCL2 associated X, apoptosis regulator a.	0.999
Bcl2l1	ENSAMXP00000038752	ENSAMXP00000041865	ENSAMXP00000038752	BCL2 like 1.	Uncharacterized protein.	0.423
Bcl2l1	LOC103032659	ENSAMXP00000041865	ENSAMXP00000029182	BCL2 like 1.	BCL2 associated agonist of cell death b.	0.999
Bcl2l1	LOC103035823	ENSAMXP00000041865	ENSAMXP00000016778	BCL2 like 1.	BCL2 like 10.	0.597
Bcl2l1	LOC103042396	ENSAMXP00000041865	ENSAMXP00000040866	BCL2 like 1.	Uncharacterized protein.	0.958
Bcl2l1	LOC103046057	ENSAMXP00000041865	ENSAMXP00000048964	BCL2 like 1.	MCL1 apoptosis regulator, BCL2 family member b.	0.423
Bcl2l1	LOC103047816	ENSAMXP00000041865	ENSAMXP00000007605	BCL2 like 1.	Zgc:153993.	0.995
Bcl2l1	LOC111197410	ENSAMXP00000041865	ENSAMXP00000028473	BCL2 like 1.	Uncharacterized protein.	0.423
Bcl2l1	bcl2l11	ENSAMXP00000041865	ENSAMXP00000046456	BCL2 like 1.	Bclx_interact domain-containing protein.	0.999
Bcl2l1	casp2	ENSAMXP00000041865	ENSAMXP00000048020	BCL2 like 1.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.635
Bcl2l1	fadd	ENSAMXP00000041865	ENSAMXP00000007593	BCL2 like 1.	Fas (tnfrsf6)-associated via death domain.	0.669
ENSAMXP00000038752	Bax	ENSAMXP00000038752	ENSAMXP00000005311	Uncharacterized protein.	BCL2 associated X, apoptosis regulator a.	0.869
ENSAMXP00000038752	Bcl2l1	ENSAMXP00000038752	ENSAMXP00000041865	Uncharacterized protein.	BCL2 like 1.	0.423