(28 nodes) Desmosome network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAMXP00000028268	Kazrin, periplakin interacting protein b. (499 aa)
	actn4	Actinin, alpha 4. (899 aa)
	LOC103034091	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (897 aa)
	W5K4F8_ASTMX	Si:ch73-74h11.1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1063 aa)
	W5K4G3_ASTMX	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1233 aa)
	W5KDJ8_ASTMX	Junction plakoglobin b. (709 aa)
	LOC103025382	Plakophilin 3b. (792 aa)
	klhl6	BTB domain-containing protein. (614 aa)
	LOC103026629	BTB domain-containing protein. (600 aa)
	KLHL35	Kelch like family member 35. (545 aa)
	LOC103024106	Actinin, alpha 2b. (896 aa)
	LOC103029649	Kelch-like family member 24a. (599 aa)
	W5L865_ASTMX	Si:dkey-22o22.2; Cadherins are calcium-dependent cell adhesion proteins. (2708 aa)
	W5L9B0_ASTMX	Actinin alpha 3a. (897 aa)
	LOC103046265	Plakophilin 3a. (896 aa)
	LOC103045821	Junction plakoglobin a. (724 aa)
	W5LIR7_ASTMX	Si:ch211-186j3.6. (2609 aa)
	W5LQ48_ASTMX	Actinin alpha 3b. (799 aa)
	Cdh26	Cadherin 26, tandem duplicate 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (598 aa)
	LOC103034413	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1242 aa)
	ENSAMXP00000034482	Kazrin, periplakin interacting protein a. (630 aa)
	ENSAMXP00000037896	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (973 aa)
	pnn	Pinin, desmosome associated protein. (741 aa)
	LOC103034870	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1086 aa)
	actn1	Actinin, alpha 1. (923 aa)
	LOC103021864	Si:ch211-256e16.3. (621 aa)
	ACTN2	Actinin alpha 2. (890 aa)
	LOC103031848	Junctional adhesion molecule 3b. (314 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000037896	LOC103025382	ENSAMXP00000037896	ENSAMXP00000006241	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3b.	0.606
ENSAMXP00000037896	LOC103034091	ENSAMXP00000037896	ENSAMXP00000002450	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.747
ENSAMXP00000037896	LOC103045821	ENSAMXP00000037896	ENSAMXP00000018907	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin a.	0.656
ENSAMXP00000037896	LOC103046265	ENSAMXP00000037896	ENSAMXP00000018405	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3a.	0.606
ENSAMXP00000037896	W5KDJ8_ASTMX	ENSAMXP00000037896	ENSAMXP00000005659	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin b.	0.656
LOC103025382	ENSAMXP00000037896	ENSAMXP00000006241	ENSAMXP00000037896	Plakophilin 3b.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.606
LOC103025382	LOC103034091	ENSAMXP00000006241	ENSAMXP00000002450	Plakophilin 3b.	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.722
LOC103025382	LOC103034870	ENSAMXP00000006241	ENSAMXP00000041186	Plakophilin 3b.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.606
LOC103025382	LOC103045821	ENSAMXP00000006241	ENSAMXP00000018907	Plakophilin 3b.	Junction plakoglobin a.	0.627
LOC103025382	W5K4F8_ASTMX	ENSAMXP00000006241	ENSAMXP00000002469	Plakophilin 3b.	Si:ch73-74h11.1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.606
LOC103025382	W5K4G3_ASTMX	ENSAMXP00000006241	ENSAMXP00000002474	Plakophilin 3b.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.606
LOC103025382	W5KDJ8_ASTMX	ENSAMXP00000006241	ENSAMXP00000005659	Plakophilin 3b.	Junction plakoglobin b.	0.627
LOC103034091	ENSAMXP00000037896	ENSAMXP00000002450	ENSAMXP00000037896	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.747
LOC103034091	LOC103025382	ENSAMXP00000002450	ENSAMXP00000006241	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3b.	0.722
LOC103034091	LOC103034870	ENSAMXP00000002450	ENSAMXP00000041186	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.721
LOC103034091	LOC103045821	ENSAMXP00000002450	ENSAMXP00000018907	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin a.	0.871
LOC103034091	LOC103046265	ENSAMXP00000002450	ENSAMXP00000018405	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin 3a.	0.722
LOC103034091	W5K4F8_ASTMX	ENSAMXP00000002450	ENSAMXP00000002469	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Si:ch73-74h11.1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.721
LOC103034091	W5K4G3_ASTMX	ENSAMXP00000002450	ENSAMXP00000002474	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.721
LOC103034091	W5KDJ8_ASTMX	ENSAMXP00000002450	ENSAMXP00000005659	Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Junction plakoglobin b.	0.850