(6 nodes) HOPS complex network (Astyanax mexicanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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protein homology

Your Input:
	Vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (946 aa)
	vps41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
	vps8	VPS8 subunit of CORVET complex. (1409 aa)
	WDR88	WD repeat domain 88. (395 aa)
	vps39	VPS39 subunit of HOPS complex. (875 aa)
	vps18	VPS18 core subunit of CORVET and HOPS complexes. (978 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Vps11	vps18	ENSAMXP00000004514	ENSAMXP00000017763	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS18 core subunit of CORVET and HOPS complexes.	0.999
Vps11	vps39	ENSAMXP00000004514	ENSAMXP00000048859	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS39 subunit of HOPS complex.	0.999
Vps11	vps41	ENSAMXP00000004514	ENSAMXP00000002952	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.999
Vps11	vps8	ENSAMXP00000004514	ENSAMXP00000000649	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	VPS8 subunit of CORVET complex.	0.993
vps18	Vps11	ENSAMXP00000017763	ENSAMXP00000004514	VPS18 core subunit of CORVET and HOPS complexes.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.999
vps18	vps39	ENSAMXP00000017763	ENSAMXP00000048859	VPS18 core subunit of CORVET and HOPS complexes.	VPS39 subunit of HOPS complex.	0.999
vps18	vps41	ENSAMXP00000017763	ENSAMXP00000002952	VPS18 core subunit of CORVET and HOPS complexes.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.999
vps18	vps8	ENSAMXP00000017763	ENSAMXP00000000649	VPS18 core subunit of CORVET and HOPS complexes.	VPS8 subunit of CORVET complex.	0.993
vps39	Vps11	ENSAMXP00000048859	ENSAMXP00000004514	VPS39 subunit of HOPS complex.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.999
vps39	vps18	ENSAMXP00000048859	ENSAMXP00000017763	VPS39 subunit of HOPS complex.	VPS18 core subunit of CORVET and HOPS complexes.	0.999
vps39	vps41	ENSAMXP00000048859	ENSAMXP00000002952	VPS39 subunit of HOPS complex.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.999
vps39	vps8	ENSAMXP00000048859	ENSAMXP00000000649	VPS39 subunit of HOPS complex.	VPS8 subunit of CORVET complex.	0.925
vps41	Vps11	ENSAMXP00000002952	ENSAMXP00000004514	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.999
vps41	vps18	ENSAMXP00000002952	ENSAMXP00000017763	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	VPS18 core subunit of CORVET and HOPS complexes.	0.999
vps41	vps39	ENSAMXP00000002952	ENSAMXP00000048859	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	VPS39 subunit of HOPS complex.	0.999
vps41	vps8	ENSAMXP00000002952	ENSAMXP00000000649	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	VPS8 subunit of CORVET complex.	0.759
vps8	Vps11	ENSAMXP00000000649	ENSAMXP00000004514	VPS8 subunit of CORVET complex.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.993
vps8	vps18	ENSAMXP00000000649	ENSAMXP00000017763	VPS8 subunit of CORVET complex.	VPS18 core subunit of CORVET and HOPS complexes.	0.993
vps8	vps39	ENSAMXP00000000649	ENSAMXP00000048859	VPS8 subunit of CORVET complex.	VPS39 subunit of HOPS complex.	0.925
vps8	vps41	ENSAMXP00000000649	ENSAMXP00000002952	VPS8 subunit of CORVET complex.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.759