(26 nodes) Sarcoplasmic reticulum membrane network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC103032713	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1. (628 aa)
	LOC103024029	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
	SRL	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (598 aa)
	LOC103046747	Ring finger protein 175. (313 aa)
	LOC103021660	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1065 aa)
	LOC103026931	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (522 aa)
	Cherp	Calcium homeostasis endoplasmic reticulum protein. (987 aa)
	W5KV56_ASTMX	Ryanodine receptor 2b (cardiac). (4690 aa)
	W5KSD8_ASTMX	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1033 aa)
	W5KMZ7_ASTMX	Ryanodine receptor 1a (skeletal). (4937 aa)
	Akap6	Uncharacterized protein. (728 aa)
	W5KBL7_ASTMX	Ryanodine receptor 3. (4703 aa)
	LOC103029426	Asp_Arg_Hydrox domain-containing protein. (396 aa)
	LOC103044865	Si:ch211-270g19.5. (52 aa)
	asphd2	Aspartate beta-hydroxylase domain containing 2. (375 aa)
	ENSAMXP00000053023	Uncharacterized protein. (150 aa)
	ENSAMXP00000052534	Un-named hu7910. (579 aa)
	ENSAMXP00000050759	B30.2/SPRY domain-containing protein. (303 aa)
	RNF121	Ring finger protein 121. (332 aa)
	LOC103039228	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (993 aa)
	ENSAMXP00000044622	Ins145_P3_rec domain-containing protein. (117 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	camk2g	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2. (544 aa)
	LOC103040450	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1041 aa)
	Ryr1	Ryanodine receptor 1b (skeletal). (4957 aa)
	ENSAMXP00000053261	annotation not available (35 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000044622	ENSAMXP00000050759	ENSAMXP00000044622	ENSAMXP00000050759	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.935
ENSAMXP00000050759	ENSAMXP00000044622	ENSAMXP00000050759	ENSAMXP00000044622	B30.2/SPRY domain-containing protein.	Ins145_P3_rec domain-containing protein.	0.935
ENSAMXP00000050759	ENSAMXP00000052534	ENSAMXP00000050759	ENSAMXP00000052534	B30.2/SPRY domain-containing protein.	Un-named hu7910.	0.536
ENSAMXP00000052534	ENSAMXP00000050759	ENSAMXP00000052534	ENSAMXP00000050759	Un-named hu7910.	B30.2/SPRY domain-containing protein.	0.536
ENSAMXP00000052534	Ryr1	ENSAMXP00000052534	ENSAMXP00000054931	Un-named hu7910.	Ryanodine receptor 1b (skeletal).	0.536
ENSAMXP00000052534	W5KBL7_ASTMX	ENSAMXP00000052534	ENSAMXP00000004978	Un-named hu7910.	Ryanodine receptor 3.	0.536
ENSAMXP00000052534	W5KMZ7_ASTMX	ENSAMXP00000052534	ENSAMXP00000008959	Un-named hu7910.	Ryanodine receptor 1a (skeletal).	0.536
ENSAMXP00000052534	W5KV56_ASTMX	ENSAMXP00000052534	ENSAMXP00000011468	Un-named hu7910.	Ryanodine receptor 2b (cardiac).	0.536
ENSAMXP00000053261	LOC103021660	ENSAMXP00000053261	ENSAMXP00000029838	annotation not available	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.628
ENSAMXP00000053261	LOC103024029	ENSAMXP00000053261	ENSAMXP00000035061	annotation not available	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.655
ENSAMXP00000053261	LOC103039228	ENSAMXP00000053261	ENSAMXP00000044188	annotation not available	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.655
ENSAMXP00000053261	LOC103040450	ENSAMXP00000053261	ENSAMXP00000040033	annotation not available	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.655
ENSAMXP00000053261	W5KSD8_ASTMX	ENSAMXP00000053261	ENSAMXP00000010500	annotation not available	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.655
LOC103021660	ENSAMXP00000053261	ENSAMXP00000029838	ENSAMXP00000053261	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	annotation not available	0.628
LOC103021660	LOC103026931	ENSAMXP00000029838	ENSAMXP00000019350	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.407
LOC103021660	LOC103044865	ENSAMXP00000029838	ENSAMXP00000046996	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Si:ch211-270g19.5.	0.961
LOC103021660	PLN	ENSAMXP00000029838	ENSAMXP00000050211	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.961
LOC103021660	SRL	ENSAMXP00000029838	ENSAMXP00000034423	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.407
LOC103024029	ENSAMXP00000053261	ENSAMXP00000035061	ENSAMXP00000053261	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	annotation not available	0.655
LOC103024029	LOC103026931	ENSAMXP00000035061	ENSAMXP00000019350	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.452