(61 nodes) p53-like transcription factor, DNA-binding domain superfamily network (Astyanax mexicanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103033010	Signal transducer and activator of transcription. (752 aa)
	LOC103034389	RHD domain-containing protein. (836 aa)
	Runx2	Runt-related transcription factor. (417 aa)
	LOC103046625	Uncharacterized protein. (461 aa)
	W5K0X4_ASTMX	T-box transcription factor 16. (479 aa)
	Nfatc4	Nuclear factor of activated T cells 4. (812 aa)
	W5K777_ASTMX	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (877 aa)
	W5K922_ASTMX	T-box transcription factor Tb. (416 aa)
	LOC103033509	T-box transcription factor 19. (430 aa)
	LOC103025714	BHLH domain-containing protein. (2632 aa)
	W5KGB2_ASTMX	Nuclear factor of activated T cells 5b. (1450 aa)
	Rbpjl	Recombination signal binding protein for immunoglobulin kappa J region-like. (465 aa)
	Tbx5	T-box transcription factor 5a. (522 aa)
	W5KPS9_ASTMX	T-box transcription factor 6. (895 aa)
	TBX10	T-box transcription factor 10. (196 aa)
	tbr1	T-box brain transcription factor 1b. (713 aa)
	Tbx21	T-box transcription factor 21. (577 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region b. (494 aa)
	LOC103029567	Recombination signal binding protein for immunoglobulin kappa J region a. (502 aa)
	LOC103021407	Signal transducer and activator of transcription. (830 aa)
	TBX22	T-box transcription factor 22. (510 aa)
	LOC103038161	T-box transcription factor Ta. (422 aa)
	W5L336_ASTMX	Signal transducer and activator of transcription. (784 aa)
	LOC103042656	Signal transducer and activator of transcription. (786 aa)
	W5LEF4_ASTMX	Nuclear factor of activated T cells 3b. (994 aa)
	W5LFF5_ASTMX	RHD domain-containing protein. (846 aa)
	Stat4	Signal transducer and activator of transcription. (731 aa)
	W5LMI9_ASTMX	T-box transcription factor 1. (417 aa)
	Tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
	Myrfl	Myelin regulatory factor like. (985 aa)
	nfkb2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (908 aa)
	ENSAMXP00000027242	Uncharacterized protein. (716 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (687 aa)
	tbx4	T-box transcription factor 4. (558 aa)
	LOC103031023	T-box transcription factor 5b. (423 aa)
	LOC103041531	Runt-related transcription factor. (449 aa)
	tbx2	T-box transcription factor 2b. (692 aa)
	LOC103037427	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (394 aa)
	tbx15	T-box transcription factor 15. (611 aa)
	LOC103031000	Signal transducer and activator of transcription. (745 aa)
	LOC103028241	Runt-related transcription factor. (464 aa)
	ENSAMXP00000038847	Signal transducer and activator of transcription 6, interleukin-4 induced. (679 aa)
	nfatc1	Nuclear factor of activated T cells 1. (862 aa)
	LOC103031729	V-rel avian reticuloendotheliosis viral oncogene homolog B. (583 aa)
	ENSAMXP00000041702	Eomesodermin homolog b. (512 aa)
	LOC103032041	V-rel avian reticuloendotheliosis viral oncogene homolog A. (615 aa)
	LOC103034219	Eomesodermin homolog a. (720 aa)
	W5K9M8_ASTMX	Uncharacterized protein. (174 aa)
	LOC103030550	Nuclear factor of activated T cells 5a. (1452 aa)
	tbx3	T-box transcription factor 3a. (706 aa)
	LOC103025657	Runt-related transcription factor. (468 aa)
	LOC103029075	Nuclear factor of activated T cells 3a. (1092 aa)
	ENSAMXP00000049285	T-box transcription factor 16, like. (425 aa)
	LOC103036111	T-box transcription factor 18. (580 aa)
	myrf	Myelin regulatory factor. (788 aa)
	stat3	Signal transducer and activator of transcription. (788 aa)
	LOC111188591	Eomesodermin homolog b. (568 aa)
	rel	V-rel avian reticuloendotheliosis viral oncogene homolog. (616 aa)
	tp73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (641 aa)
	tbx20	T-box transcription factor 20. (441 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (902 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000038847	LOC103021407	ENSAMXP00000038847	ENSAMXP00000013413	Signal transducer and activator of transcription 6, interleukin-4 induced.	Signal transducer and activator of transcription.	0.600
ENSAMXP00000038847	LOC103031000	ENSAMXP00000038847	ENSAMXP00000038038	Signal transducer and activator of transcription 6, interleukin-4 induced.	Signal transducer and activator of transcription.	0.516
ENSAMXP00000038847	Stat4	ENSAMXP00000038847	ENSAMXP00000019141	Signal transducer and activator of transcription 6, interleukin-4 induced.	Signal transducer and activator of transcription.	0.539
ENSAMXP00000038847	Tbx21	ENSAMXP00000038847	ENSAMXP00000010803	Signal transducer and activator of transcription 6, interleukin-4 induced.	T-box transcription factor 21.	0.429
ENSAMXP00000038847	W5L336_ASTMX	ENSAMXP00000038847	ENSAMXP00000014248	Signal transducer and activator of transcription 6, interleukin-4 induced.	Signal transducer and activator of transcription.	0.512
ENSAMXP00000038847	rel	ENSAMXP00000038847	ENSAMXP00000053280	Signal transducer and activator of transcription 6, interleukin-4 induced.	V-rel avian reticuloendotheliosis viral oncogene homolog.	0.566
ENSAMXP00000038847	stat3	ENSAMXP00000038847	ENSAMXP00000050869	Signal transducer and activator of transcription 6, interleukin-4 induced.	Signal transducer and activator of transcription.	0.498
ENSAMXP00000041702	LOC103031023	ENSAMXP00000041702	ENSAMXP00000032429	Eomesodermin homolog b.	T-box transcription factor 5b.	0.402
ENSAMXP00000041702	LOC103033509	ENSAMXP00000041702	ENSAMXP00000005165	Eomesodermin homolog b.	T-box transcription factor 19.	0.450
ENSAMXP00000041702	LOC103038161	ENSAMXP00000041702	ENSAMXP00000014052	Eomesodermin homolog b.	T-box transcription factor Ta.	0.450
ENSAMXP00000041702	Tbx21	ENSAMXP00000041702	ENSAMXP00000010803	Eomesodermin homolog b.	T-box transcription factor 21.	0.433
ENSAMXP00000041702	W5K922_ASTMX	ENSAMXP00000041702	ENSAMXP00000004083	Eomesodermin homolog b.	T-box transcription factor Tb.	0.450
LOC103021407	ENSAMXP00000038847	ENSAMXP00000013413	ENSAMXP00000038847	Signal transducer and activator of transcription.	Signal transducer and activator of transcription 6, interleukin-4 induced.	0.600
LOC103021407	LOC103031000	ENSAMXP00000013413	ENSAMXP00000038038	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.957
LOC103021407	LOC103033010	ENSAMXP00000013413	ENSAMXP00000000502	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.528
LOC103021407	LOC103042656	ENSAMXP00000013413	ENSAMXP00000014394	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.555
LOC103021407	W5L336_ASTMX	ENSAMXP00000013413	ENSAMXP00000014248	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.973
LOC103025657	LOC103029567	ENSAMXP00000048253	ENSAMXP00000011492	Runt-related transcription factor.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.427
LOC103025657	LOC103037427	ENSAMXP00000048253	ENSAMXP00000035025	Runt-related transcription factor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.558
LOC103025657	Tp53	ENSAMXP00000048253	ENSAMXP00000021366	Runt-related transcription factor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.598