24 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cct4	T-complex protein 1 subunit delta. (582 aa)
	hspe1	Heat shock 10 protein 1; Belongs to the GroES chaperonin family. (238 aa)
	tcp1	T-complex 1. (558 aa)
	W5L5S1_ASTMX	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (212 aa)
	LOC103040817	Calreticulin. (423 aa)
	canx	Calnexin. (610 aa)
	cct6a	Chaperonin containing TCP1, subunit 6A (zeta 1). (531 aa)
	cct3	T-complex protein 1 subunit gamma. (541 aa)
	LOC103024869	Calreticulin. (423 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)
	W5LQI6_ASTMX	Calreticulin. (390 aa)
	timm8a	Translocase of inner mitochondrial membrane 8 homolog A (yeast); Belongs to the small Tim family. (90 aa)
	Rsad1	Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (508 aa)
	cct8	Chaperonin containing TCP1, subunit 8 (theta). (558 aa)
	Mdn1	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4952 aa)
	pfdn4	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. (135 aa)
	LOC103035256	Calmegin. (645 aa)
	timm13	Translocase of inner mitochondrial membrane 13 homolog (yeast); Belongs to the small Tim family. (113 aa)
	sdhaf2	Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (159 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (535 aa)
	tbca	Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
	timm8b	Translocase of inner mitochondrial membrane 8 homolog B (yeast); Belongs to the small Tim family. (94 aa)
	cct7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (567 aa)
	LOC103044137	Si:ch211-274f20.2. (533 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cct4	W5L5S1_ASTMX	ENSAMXP00000003135	ENSAMXP00000015183	T-complex protein 1 subunit delta.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.715
Cct4	cct2	ENSAMXP00000003135	ENSAMXP00000049423	T-complex protein 1 subunit delta.	Chaperonin containing TCP1, subunit 2 (beta).	0.999
Cct4	cct3	ENSAMXP00000003135	ENSAMXP00000019003	T-complex protein 1 subunit delta.	T-complex protein 1 subunit gamma.	0.999
Cct4	cct5	ENSAMXP00000003135	ENSAMXP00000021238	T-complex protein 1 subunit delta.	Chaperonin containing TCP1, subunit 5 (epsilon).	0.999
Cct4	cct6a	ENSAMXP00000003135	ENSAMXP00000017688	T-complex protein 1 subunit delta.	Chaperonin containing TCP1, subunit 6A (zeta 1).	0.999
Cct4	cct7	ENSAMXP00000003135	ENSAMXP00000052637	T-complex protein 1 subunit delta.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
Cct4	cct8	ENSAMXP00000003135	ENSAMXP00000036009	T-complex protein 1 subunit delta.	Chaperonin containing TCP1, subunit 8 (theta).	0.999
Cct4	hspe1	ENSAMXP00000003135	ENSAMXP00000002247	T-complex protein 1 subunit delta.	Heat shock 10 protein 1; Belongs to the GroES chaperonin family.	0.860
Cct4	pfdn4	ENSAMXP00000003135	ENSAMXP00000040947	T-complex protein 1 subunit delta.	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	0.903
Cct4	tbca	ENSAMXP00000003135	ENSAMXP00000051008	T-complex protein 1 subunit delta.	Tubulin-specific chaperone A; Belongs to the TBCA family.	0.435
Cct4	tcp1	ENSAMXP00000003135	ENSAMXP00000011128	T-complex protein 1 subunit delta.	T-complex 1.	0.999
LOC103024869	LOC103035256	ENSAMXP00000019127	ENSAMXP00000041696	Calreticulin.	Calmegin.	0.819
LOC103024869	LOC103040817	ENSAMXP00000019127	ENSAMXP00000015561	Calreticulin.	Calreticulin.	0.911
LOC103024869	LOC103044137	ENSAMXP00000019127	ENSAMXP00000053806	Calreticulin.	Si:ch211-274f20.2.	0.791
LOC103024869	canx	ENSAMXP00000019127	ENSAMXP00000015633	Calreticulin.	Calnexin.	0.819
LOC103035256	LOC103024869	ENSAMXP00000041696	ENSAMXP00000019127	Calmegin.	Calreticulin.	0.819
LOC103035256	LOC103040817	ENSAMXP00000041696	ENSAMXP00000015561	Calmegin.	Calreticulin.	0.819
LOC103035256	W5LQI6_ASTMX	ENSAMXP00000041696	ENSAMXP00000022283	Calmegin.	Calreticulin.	0.819
LOC103040817	LOC103024869	ENSAMXP00000015561	ENSAMXP00000019127	Calreticulin.	Calreticulin.	0.911
LOC103040817	LOC103035256	ENSAMXP00000015561	ENSAMXP00000041696	Calreticulin.	Calmegin.	0.819