47 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rfc2	Replication factor C (activator 1) 2. (405 aa)
	Cul4b	Cullin 4B; Belongs to the cullin family. (853 aa)
	ddb2	Damage-specific DNA binding protein 2. (488 aa)
	pold1	DNA polymerase. (1122 aa)
	rfc5	Replication factor C (activator 1) 5. (334 aa)
	Pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2003 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (460 aa)
	parp2	Poly [ADP-ribose] polymerase. (642 aa)
	parp1	Poly [ADP-ribose] polymerase. (1021 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	W5KX74_ASTMX	Basic, immunoglobulin-like variable motif containing. (478 aa)
	polk	Polymerase (DNA directed) kappa. (944 aa)
	Cul4a	Cullin 4A; Belongs to the cullin family. (612 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (467 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (547 aa)
	Pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (542 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
	Rfc1	Replication factor C subunit 1. (1189 aa)
	Chd1l	Chromodomain helicase DNA binding protein 1-like. (997 aa)
	LOC103021798	RPA_C domain-containing protein. (247 aa)
	rpa3	Uncharacterized protein. (125 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ercc5	Excision repair cross-complementation group 5. (1209 aa)
	Rfc4	Replication factor C (activator 1) 4. (374 aa)
	Rcbtb1	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	rpa2	Replication protein A2. (281 aa)
	kxd1	KxDL motif containing 1. (181 aa)
	parp3	Poly [ADP-ribose] polymerase. (631 aa)
	ercc3	Excision repair cross-complementation group 3. (781 aa)
	UBB	Ubiquitin B. (394 aa)
	pold4	Si:dkey-28b4.7. (109 aa)
	ENSAMXP00000044509	Xeroderma pigmentosum, complementation group A. (273 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (192 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (307 aa)
	Rbx1	Ring-box 1, E3 ubiquitin protein ligase. (123 aa)
	ENSAMXP00000046987	XPA_C domain-containing protein. (198 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (149 aa)
	ENSAMXP00000048712	CULLIN_2 domain-containing protein; Belongs to the cullin family. (635 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (466 aa)
	ercc1	Excision repair cross-complementation group 1. (361 aa)
	LOC103036617	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	ENSAMXP00000052495	Damage-specific DNA binding protein 1. (304 aa)
	gtf2h2c	General transcription factor IIH subunit. (393 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chd1l	Cul4a	ENSAMXP00000030360	ENSAMXP00000016624	Chromodomain helicase DNA binding protein 1-like.	Cullin 4A; Belongs to the cullin family.	0.554
Chd1l	Cul4b	ENSAMXP00000030360	ENSAMXP00000000231	Chromodomain helicase DNA binding protein 1-like.	Cullin 4B; Belongs to the cullin family.	0.554
Chd1l	ENSAMXP00000044509	ENSAMXP00000030360	ENSAMXP00000044509	Chromodomain helicase DNA binding protein 1-like.	Xeroderma pigmentosum, complementation group A.	0.682
Chd1l	ENSAMXP00000046987	ENSAMXP00000030360	ENSAMXP00000046987	Chromodomain helicase DNA binding protein 1-like.	XPA_C domain-containing protein.	0.682
Chd1l	ENSAMXP00000048712	ENSAMXP00000030360	ENSAMXP00000048712	Chromodomain helicase DNA binding protein 1-like.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.554
Chd1l	ENSAMXP00000052495	ENSAMXP00000030360	ENSAMXP00000052495	Chromodomain helicase DNA binding protein 1-like.	Damage-specific DNA binding protein 1.	0.699
Chd1l	LOC103021798	ENSAMXP00000030360	ENSAMXP00000033311	Chromodomain helicase DNA binding protein 1-like.	RPA_C domain-containing protein.	0.519
Chd1l	Rbx1	ENSAMXP00000030360	ENSAMXP00000046688	Chromodomain helicase DNA binding protein 1-like.	Ring-box 1, E3 ubiquitin protein ligase.	0.670
Chd1l	UBB	ENSAMXP00000030360	ENSAMXP00000040893	Chromodomain helicase DNA binding protein 1-like.	Ubiquitin B.	0.673
Chd1l	W5KX74_ASTMX	ENSAMXP00000030360	ENSAMXP00000012186	Chromodomain helicase DNA binding protein 1-like.	Basic, immunoglobulin-like variable motif containing.	0.701
Chd1l	ddb2	ENSAMXP00000030360	ENSAMXP00000000544	Chromodomain helicase DNA binding protein 1-like.	Damage-specific DNA binding protein 2.	0.818
Chd1l	ercc1	ENSAMXP00000030360	ENSAMXP00000051638	Chromodomain helicase DNA binding protein 1-like.	Excision repair cross-complementation group 1.	0.574
Chd1l	ercc2	ENSAMXP00000030360	ENSAMXP00000009302	Chromodomain helicase DNA binding protein 1-like.	Excision repair cross-complementation group 2.	0.665
Chd1l	ercc3	ENSAMXP00000030360	ENSAMXP00000040528	Chromodomain helicase DNA binding protein 1-like.	Excision repair cross-complementation group 3.	0.721
Chd1l	ercc5	ENSAMXP00000030360	ENSAMXP00000036778	Chromodomain helicase DNA binding protein 1-like.	Excision repair cross-complementation group 5.	0.701
Chd1l	gtf2h1	ENSAMXP00000030360	ENSAMXP00000019269	Chromodomain helicase DNA binding protein 1-like.	General transcription factor IIH, polypeptide 1.	0.660
Chd1l	gtf2h2c	ENSAMXP00000030360	ENSAMXP00000052880	Chromodomain helicase DNA binding protein 1-like.	General transcription factor IIH subunit.	0.640
Chd1l	gtf2h3	ENSAMXP00000030360	ENSAMXP00000046460	Chromodomain helicase DNA binding protein 1-like.	General transcription factor IIH, polypeptide 3.	0.634
Chd1l	gtf2h5	ENSAMXP00000030360	ENSAMXP00000052385	Chromodomain helicase DNA binding protein 1-like.	General transcription factor IIH, polypeptide 5.	0.681
Chd1l	parp1	ENSAMXP00000030360	ENSAMXP00000006642	Chromodomain helicase DNA binding protein 1-like.	Poly [ADP-ribose] polymerase.	0.927