16 items (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Clock	Clock circadian regulator a. (917 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC103042476	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	ENSAMXP00000043572	Arrestin, beta 2b. (659 aa)
	MC4R	Melanocortin 4 receptor. (338 aa)
	Ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (151 aa)
	LOC103039445	Tyrosine-protein kinase receptor. (1359 aa)
	ENSAMXP00000035546	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (56 aa)
	LOC103044559	Cryptochrome circadian regulator 2. (618 aa)
	LOC103047075	Glucagon a. (172 aa)
	LOC103028370	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	W5LUY0_ASTMX	Melanocortin 4 receptor. (326 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2518 aa)
	W5KSL3_ASTMX	Arrestin, beta 1. (375 aa)
	Gcg	Glucagon b. (139 aa)
	Cry1	Cryptochrome circadian regulator 1b. (573 aa)

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Clock	Cry1	ENSAMXP00000005699	ENSAMXP00000000154	Clock circadian regulator a.	Cryptochrome circadian regulator 1b.	0.754
Clock	LOC103044559	ENSAMXP00000005699	ENSAMXP00000031864	Clock circadian regulator a.	Cryptochrome circadian regulator 2.	0.762
Cry1	Clock	ENSAMXP00000000154	ENSAMXP00000005699	Cryptochrome circadian regulator 1b.	Clock circadian regulator a.	0.754
ENSAMXP00000035546	Gcg	ENSAMXP00000035546	ENSAMXP00000010272	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon b.	0.738
ENSAMXP00000035546	LOC103039445	ENSAMXP00000035546	ENSAMXP00000037399	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.849
ENSAMXP00000035546	LOC103047075	ENSAMXP00000035546	ENSAMXP00000029612	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon a.	0.552
ENSAMXP00000035546	MC4R	ENSAMXP00000035546	ENSAMXP00000038901	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Melanocortin 4 receptor.	0.490
ENSAMXP00000035546	W5LUY0_ASTMX	ENSAMXP00000035546	ENSAMXP00000027055	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Melanocortin 4 receptor.	0.490
ENSAMXP00000043572	LOC103042476	ENSAMXP00000043572	ENSAMXP00000051642	Arrestin, beta 2b.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.412
ENSAMXP00000043572	MC4R	ENSAMXP00000043572	ENSAMXP00000038901	Arrestin, beta 2b.	Melanocortin 4 receptor.	0.480
ENSAMXP00000043572	W5KSL3_ASTMX	ENSAMXP00000043572	ENSAMXP00000010575	Arrestin, beta 2b.	Arrestin, beta 1.	0.914
ENSAMXP00000043572	W5LUY0_ASTMX	ENSAMXP00000043572	ENSAMXP00000027055	Arrestin, beta 2b.	Melanocortin 4 receptor.	0.480
Gcg	ENSAMXP00000035546	ENSAMXP00000010272	ENSAMXP00000035546	Glucagon b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.738
Gcg	Ins	ENSAMXP00000010272	ENSAMXP00000038774	Glucagon b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.738
Gcg	LOC103047075	ENSAMXP00000010272	ENSAMXP00000029612	Glucagon b.	Glucagon a.	0.903
Ins	Gcg	ENSAMXP00000038774	ENSAMXP00000010272	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon b.	0.738
Ins	LOC103039445	ENSAMXP00000038774	ENSAMXP00000037399	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.984
Ins	LOC103047075	ENSAMXP00000038774	ENSAMXP00000029612	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon a.	0.552
Ins	MC4R	ENSAMXP00000038774	ENSAMXP00000038901	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Melanocortin 4 receptor.	0.490
Ins	W5LUY0_ASTMX	ENSAMXP00000038774	ENSAMXP00000027055	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Melanocortin 4 receptor.	0.490