STRINGSTRING
wee2 wee2 espl1 espl1 anapc4 anapc4 LOC103041458 LOC103041458 tgfb1 tgfb1 ccne1 ccne1 skp2 skp2 LOC103043213 LOC103043213 chek2 chek2 wee1 wee1 bub3 bub3 Mcm4 Mcm4 smc3 smc3 mcm2 mcm2 anapc10 anapc10 Rb1 Rb1 W5KDX2_ASTMX W5KDX2_ASTMX anapc5 anapc5 gadd45g gadd45g anapc11 anapc11 orc5 orc5 Prkdc Prkdc W5KIX6_ASTMX W5KIX6_ASTMX LOC103044365 LOC103044365 LOC103044077 LOC103044077 orc4 orc4 cdk7 cdk7 gsk3b gsk3b LOC103039224 LOC103039224 rbl1 rbl1 MCM7 MCM7 LOC103024607 LOC103024607 anapc7 anapc7 LOC103028876 LOC103028876 ccnb1 ccnb1 CDC25B CDC25B Bub1b Bub1b Zbtb17 Zbtb17 LOC103030832 LOC103030832 ccna2 ccna2 smc1a smc1a ccnd2 ccnd2 ep300 ep300 bub1 bub1 cdk6 cdk6 HDAC2 HDAC2 tgfb3 tgfb3 ccnh ccnh orc3 orc3 mcm6 mcm6 Ccna1 Ccna1 ywhab ywhab tfdp1 tfdp1 E2f1 E2f1 W5LD66_ASTMX W5LD66_ASTMX rbl2 rbl2 LOC103022359 LOC103022359 cdc6 cdc6 LOC103024543 LOC103024543 LOC103029394 LOC103029394 CDC14A CDC14A cdc20 cdc20 pkmyt1 pkmyt1 W5LMH3_ASTMX W5LMH3_ASTMX pcna pcna rad21 rad21 Tp53 Tp53 LOC103040153 LOC103040153 LOC107197738 LOC107197738 gadd45b gadd45b ccnd1 ccnd1 orc6 orc6 LOC103021402 LOC103021402 stag1 stag1 LOC103027693 LOC103027693 ywhaq ywhaq cdk2 cdk2 dbf4 dbf4 LOC103027004 LOC103027004 chek1 chek1 cdkn1b cdkn1b ENSAMXP00000032430 ENSAMXP00000032430 LOC103047033 LOC103047033 ywhae ywhae ENSAMXP00000032670 ENSAMXP00000032670 LOC103039334 LOC103039334 LOC111194478 LOC111194478 fzr1 fzr1 mcm5 mcm5 LOC103043574 LOC103043574 LOC103037427 LOC103037427 cul1 cul1 smad2 smad2 LOC111194477 LOC111194477 LOC103027354 LOC103027354 LOC111189396 LOC111189396 LOC103038167 LOC103038167 cdc14a cdc14a Cdc27 Cdc27 LOC103033997 LOC103033997 WEE1 WEE1 anapc13 anapc13 abl1 abl1 e2f5 e2f5 orc2 orc2 cdk1 cdk1 anapc2 anapc2 LOC111193357 LOC111193357 LOC103027909 LOC103027909 LOC103041195 LOC103041195 E2F3 E2F3 plk1 plk1 ccne2 ccne2 LOC103029638 LOC103029638 MAD2L2 MAD2L2 LOC103041774 LOC103041774 Crebbp Crebbp cdc16 cdc16 LOC103046670 LOC103046670 Atm Atm Mad2l2 Mad2l2 cdc26 cdc26 skp1 skp1 LOC103027811 LOC103027811 Rbx1 Rbx1 mad1l1 mad1l1 LOC103043872 LOC103043872 cdkn1a cdkn1a Mdm2 Mdm2 cdkn2d cdkn2d LOC103036194 LOC103036194 cdc23 cdc23 LOC103023504 LOC103023504 cdkn2c cdkn2c LOC103023259 LOC103023259 LOC103042476 LOC103042476 LOC103045951 LOC103045951 gadd45a gadd45a tgfb2 tgfb2 LOC103030485 LOC103030485 LOC103038757 LOC103038757 LOC103045356 LOC103045356 LOC103033872 LOC103033872 cdk4 cdk4 LOC103042914 LOC103042914
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wee2Wee1-like protein kinase. (558 aa)
espl1Extra spindle pole bodies like 1, separase. (2196 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
LOC103041458Si:ch211-269e2.1. (1180 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (412 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (442 aa)
LOC103043213Cyclin B3; Belongs to the cyclin family. (425 aa)
chek2Checkpoint kinase 2. (516 aa)
wee1Wee1-like protein kinase. (616 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
Mcm4DNA helicase; Belongs to the MCM family. (815 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
mcm2DNA helicase; Belongs to the MCM family. (889 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
Rb1Retinoblastoma 1. (882 aa)
W5KDX2_ASTMXStromal antigen 2b. (1226 aa)
anapc5Anaphase promoting complex subunit 5. (768 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (157 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (88 aa)
orc5Origin recognition complex, subunit 5. (444 aa)
PrkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4082 aa)
W5KIX6_ASTMXPTTG1 regulator of sister chromatid separation, securin. (185 aa)
LOC103044365E1A binding protein p300 a. (2671 aa)
LOC103044077Stromal antigen 2a. (1255 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (345 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
LOC103039224Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (140 aa)
rbl1Retinoblastoma-like 1 (p107). (1053 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (569 aa)
LOC103024607Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
LOC103028876Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (397 aa)
CDC25BCell division cycle 25B. (556 aa)
Bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (376 aa)
Zbtb17Zinc finger and BTB domain containing 17. (855 aa)
LOC103030832RAD21 cohesin complex component like 1. (550 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (421 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
ccnd2Cyclin D2, a; Belongs to the cyclin family. (297 aa)
ep300E1A binding protein p300 b. (2652 aa)
bub1BUB1 mitotic checkpoint serine/threonine kinase. (1653 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (324 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
ccnhCyclin H; Belongs to the cyclin family. (321 aa)
orc3Origin recognition complex, subunit 3. (717 aa)
mcm6DNA helicase; Belongs to the MCM family. (831 aa)
Ccna1Cyclin A1; Belongs to the cyclin family. (401 aa)
ywhabTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a; Belongs to the 14-3-3 family. (253 aa)
tfdp1Transcription factor. (405 aa)
E2f1E2F transcription factor 1. (432 aa)
W5LD66_ASTMXMothers against decapentaplegic homolog. (573 aa)
rbl2Retinoblastoma-like 2 (p130). (1090 aa)
LOC103022359Mothers against decapentaplegic homolog. (587 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (593 aa)
LOC103024543Fizzy/cell division cycle 20 related 1b. (483 aa)
LOC103029394Mothers against decapentaplegic homolog. (544 aa)
CDC14ACell division cycle 14A. (588 aa)
cdc20Cell division cycle 20 homolog. (495 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (587 aa)
W5LMH3_ASTMXStructural maintenance of chromosomes protein. (1229 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rad21RAD21 cohesin complex component b. (636 aa)
Tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
LOC103040153Cell division cycle 14B. (602 aa)
LOC107197738Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (245 aa)
gadd45bGrowth arrest and DNA-damage-inducible, beta a. (179 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
orc6Origin recognition complex, subunit 6. (262 aa)
LOC1030214023-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
stag1Stromal antigen 1b. (1257 aa)
LOC103027693DNA helicase; Belongs to the MCM family. (807 aa)
ywhaqTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (245 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (301 aa)
dbf4DBF4 zinc finger. (665 aa)
LOC103027004Mothers against decapentaplegic homolog. (424 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (464 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (171 aa)
ENSAMXP00000032430E2F transcription factor 3. (429 aa)
LOC103047033WD_REPEATS_REGION domain-containing protein. (487 aa)
ywhaeTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa)
ENSAMXP00000032670Cyclin-dependent kinase inhibitor 1Ca. (192 aa)
LOC103039334RAD21 cohesin complex component a. (637 aa)
LOC111194478Cullin 1a; Belongs to the cullin family. (777 aa)
fzr1Fizzy/cell division cycle 20 related 1a. (495 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
LOC103043574Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (420 aa)
LOC103037427Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (394 aa)
cul1Cullin 1b; Belongs to the cullin family. (772 aa)
smad2Mothers against decapentaplegic homolog. (468 aa)
LOC111194477DNA helicase; Belongs to the MCM family. (827 aa)
LOC103027354Si:ch211-160f23.5. (375 aa)
LOC111189396ANK_REP_REGION domain-containing protein. (152 aa)
LOC103038167Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (392 aa)
cdc14aCell division cycle 14Ab. (671 aa)
Cdc27Cell division cycle 27. (521 aa)
LOC103033997Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (393 aa)
WEE1WEE1 G2 checkpoint kinase; Belongs to the protein kinase superfamily. (384 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
abl1Tyrosine-protein kinase. (1107 aa)
e2f5E2F transcription factor 5. (375 aa)
orc2Origin recognition complex, subunit 2. (621 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (817 aa)
LOC111193357Cyclin Dx; Belongs to the cyclin family. (300 aa)
LOC103027909Uncharacterized protein; Belongs to the cyclin family. (429 aa)
LOC1030411953-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
E2F3E2F transcription factor 3. (420 aa)
plk1Serine/threonine-protein kinase PLK. (596 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (394 aa)
LOC103029638Growth arrest and DNA-damage-inducible, alpha, a. (163 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (213 aa)
LOC103041774Cyclin-dependent kinase inhibitor 1D. (175 aa)
CrebbpCREB binding protein a. (2140 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (611 aa)
LOC103046670Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (485 aa)
AtmNon-specific serine/threonine protein kinase. (3056 aa)
Mad2l2Mitotic arrest deficient 2 like 2. (200 aa)
cdc26Cell division cycle 26 homolog. (87 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC103027811Mothers against decapentaplegic homolog. (425 aa)
Rbx1Ring-box 1, E3 ubiquitin protein ligase. (123 aa)
mad1l1Mitotic arrest deficient 1 like 1. (717 aa)
LOC103043872Transcription factor. (418 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (174 aa)
Mdm2MDM2 proto-oncogene. (543 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (170 aa)
LOC103036194Ribosomal_L7Ae domain-containing protein. (149 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (578 aa)
LOC103023504Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (244 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (174 aa)
LOC103023259Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
LOC103042476Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
LOC103045951Transcription factor. (407 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, b. (159 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
LOC103030485Cyclin-dependent kinase inhibitor 1Ba. (204 aa)
LOC103038757E2F transcription factor 4. (150 aa)
LOC103045356Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like; Belongs to the 14-3-3 family. (245 aa)
LOC103033872Cyclin-dependent kinase inhibitor 1Cb. (213 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
LOC103042914Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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