(19 nodes) Insulin receptor signaling pathway, and PI3-kinase family, p85-binding domain network (Ictalurus punctatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	irs2	Insulin receptor substrate 2. (1071 aa)
	LOC108267420	Insulin receptor substrate 2-B-like. (1178 aa)
	LOC108267519	Insulin receptor substrate 1-B-like. (1244 aa)
	irs1	Insulin receptor substrate 1 isoform X1. (1173 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	LOC108275608	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	LOC108265420	Tyrosine-protein phosphatase non-receptor type. (439 aa)
	pik3r3	Phosphatidylinositol 3-kinase regulatory subunit alpha. (739 aa)
	pik3cb	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	LOC108278674	Insulin receptor substrate 2-B-like isoform X1. (1075 aa)
	LOC108258957	Insulin receptor substrate 2-like. (1061 aa)
	LOC108267827	Tyrosine-protein kinase receptor. (1341 aa)
	pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (728 aa)
	LOC108260367	Insulin receptor substrate 1-B-like. (1189 aa)
	LOC108271091	Tyrosine-protein kinase receptor. (1357 aa)
	LOC108259964	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	igf1r	Tyrosine-protein kinase receptor. (1395 aa)
	LOC108259786	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)

Your Current Organism:

Ictalurus punctatus

NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108258957	LOC108259786	ENSIPUP00000020253	ENSIPUP00000035672	Insulin receptor substrate 2-like.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.807
LOC108258957	LOC108259964	ENSIPUP00000020253	ENSIPUP00000033469	Insulin receptor substrate 2-like.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.807
LOC108258957	LOC108265420	ENSIPUP00000020253	ENSIPUP00000008130	Insulin receptor substrate 2-like.	Tyrosine-protein phosphatase non-receptor type.	0.917
LOC108258957	LOC108267827	ENSIPUP00000020253	ENSIPUP00000022262	Insulin receptor substrate 2-like.	Tyrosine-protein kinase receptor.	0.968
LOC108258957	LOC108271091	ENSIPUP00000020253	ENSIPUP00000033057	Insulin receptor substrate 2-like.	Tyrosine-protein kinase receptor.	0.970
LOC108258957	LOC108275608	ENSIPUP00000020253	ENSIPUP00000004902	Insulin receptor substrate 2-like.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.829
LOC108258957	igf1r	ENSIPUP00000020253	ENSIPUP00000034569	Insulin receptor substrate 2-like.	Tyrosine-protein kinase receptor.	0.970
LOC108258957	pik3ca	ENSIPUP00000020253	ENSIPUP00000004441	Insulin receptor substrate 2-like.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.829
LOC108258957	pik3cb	ENSIPUP00000020253	ENSIPUP00000013514	Insulin receptor substrate 2-like.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.829
LOC108258957	pik3cd	ENSIPUP00000020253	ENSIPUP00000005720	Insulin receptor substrate 2-like.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.829
LOC108258957	pik3r1	ENSIPUP00000020253	ENSIPUP00000025150	Insulin receptor substrate 2-like.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.909
LOC108258957	pik3r3	ENSIPUP00000020253	ENSIPUP00000008805	Insulin receptor substrate 2-like.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.909
LOC108259786	LOC108258957	ENSIPUP00000035672	ENSIPUP00000020253	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2-like.	0.807
LOC108259786	LOC108259964	ENSIPUP00000035672	ENSIPUP00000033469	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.900
LOC108259786	LOC108260367	ENSIPUP00000035672	ENSIPUP00000032143	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 1-B-like.	0.865
LOC108259786	LOC108267420	ENSIPUP00000035672	ENSIPUP00000001016	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2-B-like.	0.807
LOC108259786	LOC108267519	ENSIPUP00000035672	ENSIPUP00000001604	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 1-B-like.	0.869
LOC108259786	LOC108267827	ENSIPUP00000035672	ENSIPUP00000022262	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.976
LOC108259786	LOC108271091	ENSIPUP00000035672	ENSIPUP00000033057	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.976
LOC108259786	LOC108278674	ENSIPUP00000035672	ENSIPUP00000017930	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2-B-like isoform X1.	0.807